Thyroid Hormone Receptor ~ agonists

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Quantification of Ligand-Regulated Nuclear Receptor Corepressor and Coactivator Binding, Key Interactions Determining Ligand Potency and Efficacy for the Thyroid Hormone Receptor

http://pubs.acs.org/cgi-bin/abstract.cgi/bichaw/2008/47/i28/abs/bi800393u.html

[[...The order of TR agonist potencies is as follows: GC-1 ~ T3 ~ TRIAC ~ T4 >> rT3 (for both coactivator recruitment and corepressor dissociation); the affinities of SRC3 binding to TR-ligand complexes followed a similar trend. This highlights the fact that the low activity of rT3 is derived both from its low affinity for TR and from the low affinity of SRC for the TR-rT3 complex. The TR antagonist NH-3 failed to induce SRC3 recruitment but did effect NCoR dissociation....]]

only the abstract is available for this paper.