Anesthetic use in CMT - from Japan

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(New article on anesthetic use on a CMT patient in surgery) ~

G

1: Masui 2002 Sep;51(9):1016-9

Anesthetic management for a patient with Charcot-Marie-Tooth disease

using propofol and nitrous oxide (Article in Japanese)

Sugino S, Yamazaki Y, Nawa Y, Sato K, Sonoda H, Namiki A.

Department of Anesthesiology, Kushiro City General Hospital, Kushiro

085-0822.

A 65-year-old woman who had been diagnosed as having Charcot-Marie-Tooth

disease (CMTD) 8 years ago and was scheduled to undergo excision of a

spinal tumor in the prone position. General anesthesia using propofol

was selected as the anesthetic method in order to avoid possible

occurrence of malignant hyperthermia due to inhalation anesthetics.

The patient was given 80 mg of propofol for anesthetic induction, and

then propofol was infused at a rate of 4-5 mg.kg-1.h-1 with intermittent

administration of fentanyl (total dose of 0.25 mg) for anesthetic

maintenance. Vecuronium 4 mg was injected for intratracheal intubation,

and then vecuronium 1 mg was injected at 50 min intervals.

The operation proceeded uneventfully. The necessary time for anesthesia

was over 460 minutes. There was no delay in wakening, and the patient

experienced no problems in the postoperative course. Intravenous

anesthesia using propofol is thought to be a

safe and effective method of anesthesia for patients with CMTD.