Re: CMT treatment question -NT-3

[Guest guest]

Gretchen,

What is a clinical pilot study? This was stated in the article. I

assumed it was a clinical study with humans. Is a clinical pilot study with

mice???? Anyway, I am excited to hear of the outcome too.

Betty

[Guest guest]

Hi Betty,

Yes, I THINK a 'clinical pilot study' refers to the mice or rats or

whatever, so the Drs. can observe them all the time and keep track of

changes in them etc. A study with humans for this will most likely be in

the form of a double-blind-placebo human trial; meaning some of the

participants get the NT-3, some don't ( they get a pill but it is a

placebo) and NO ONE, not even the Drs/researchers know who gets what

till the study is completed.

And of course the humans have to check in with the Drs and report

symptoms and anything they notice and since this has to do with nerves,

I am supposing any humans that go in this trial will be subject to an

EMG, both before trial and after, since the whole thing involves nerves

and the EMG is able to show reinnervation, so that's how they will tell

if reinnervation occured or not, I guess. Like I said, on my 'to do

list' is to find out more information. Thanks to all who have emailed me

with your questions; some I had never thought about asking, so will get

on this and see what comes about.

Now this is wierd, but I wonder if they give the mice or rats a mini

EMG? Or do they just kill them and dissect to see the reinnervation??

~ Gretchen

Buchie54@... wrote:

> What is a clinical pilot study? This was stated in the article. I

> assumed it was a clinical study with humans. Is a clinical pilot study with

> mice???? Anyway, I am excited to hear of the outcome too.

[Guest guest]

Thanks Gretchen

Betty