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CMT Type 3

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CMT type 3, also called Dejerine-Sottas syndrome (DSS), is caused by point

mutations in the same genes that cause other types of CMT, such as:

- PMP 22 (CMT 1A)

- P0 (CMT 1B)

- Periaxin (CMT 4F)

- EGR 2 (CMT 1D)

Therefore blood tests for these genes can diagnose the majority of CMT3

cases (not all of them, because there is also one more CMT3 gene on locus

8q23-q24 that has not yet been identified).

Best regards,

Paolo Vinci, M.D.

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  • 2 years later...
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,

I am trying to find the articles on Type 3/Type 1. Hang on. As for " what

does all this mean " - regarding changes - well genetic research is

finding more and more types and mutations of known types and it is hard

for me to keep abreast of all of this. (I am not a geneticist, and

reading some of the technical research on genes makes my head spin!)

I guess what this means is this is good - but perhaps somewhat

confusing, as CMT seems to be harder to pin down exactly, like when I

was diagnosed - then there weren't even Type 1 and Type 2. It was 'just

CMT'! So this also means, great strides in research have been made and

they continue!

~ Gretchen

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Hey Gretchen:

No rush I know you will post the info when you find it and have a

chance to notify us.

Yes, I was in the same boat as you, there was no types when they

diagnosed me some years, and years ago. I still don't know my type,

but since there is no cure YET!! it doesn't really matter.

Docs speculate I have type 3 or 4 so your post peaked my interest.

Thanx for all info that you do post, and keep it coming. I have

learned more here in about 2 years then all the years I visited my

docs.

Take care to all.

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and Gretchen,

I'll go you one better. The first three diagnoses I received from neurologists

with excellent credentials listed me as " peripheral neuropathy of unknown

origin. " I kept looking for a Neurologist that " knew more " than the others

until I was finally referred to the Mayo Clinic in Rochester Minnesota, where

Dr. Dyck (?), who writes many of the books on our conditions resides.

To make a long story short, I left there with a diagnosis of " inherited

peripheral neuropathy, " possibly Charcot-Marie-Tooth Disease or Guillon Barre

(sure glad it wasn't the latter). It wasn't until three years ago that I was

finally informed that my official designation was CMT type 2.

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