Mice in Research - from Japan

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1: Trends Genet 2002 Dec 1;18(12):S39-S44

Mouse models of Charcot-Marie-Tooth disease.

Tanaka Y, Hirokawa N.

Dept of Cell Biology and Anatomy, Graduate School of Medicine,

University

of Tokyo, Hongo, 113-0033, Tokyo, Japan

A common peripheral neuropathy, Charcot-Marie-Tooth disease,

progressively develops with distal muscle atrophy. Several genes

expressed in Schwann cells and neurons have been identified to be

responsible for this hereditary disease, and used in generating

transgenic and knockout mice. Such mice are good disease models for cell

biological and therapeutic studies.

PMID: 12446157 [PubMed - as supplied by publisher]