RE: ATC/DDD what we learnt--

[Guest guest]

Hello ,

As the discussion is coming to an end, I would like to emphasise again that whatever activities WHO undertakes, the ultimate aim is to improve medicine use through maintaining medicine data base, rational use, availability, affordability and safety of medicine .

The ATC/DDD classification is mainly useful for the drug utilization studies. It should not be used for other purposes. The different codes for medicines can be downloaded from their site www.whocc.no Requests for assigning new ATC codes or new DDD can be made through the application form available on the same website.

Now to give you the awaited answer to problems posted by me.

For oral formulation of Neurol, because the main indication of parenteral and oral formulations differ, it is appropriate to give additional ATC code in N05A (antipsychotic).

It is not appropriate to assign additional code to Lisuride in N04 (antiparkinsonism drugs) since the dosages overlap with those used in Prolactin inhibition.

As regards the question posed by Anita Madam, No , different DDDs are not assigned to medicines used also for pediatric purposes.

Exceptions are , products which are solely used in pediatric population eg.growth hormones and fluride tablets. For guidelines too, you can log on to the same website.

I thank all those participants’posts, which indeed added to whatever postings I made.

kunda

From: anita kotwani <anitakotwani@...>Subject: RE: ATC/DDD what we learnt--netrum Date: Monday, 7 January, 2008, 12:47 PM

Dear Kunda Madam, Sorry to join in very late for the discussion. You have mentioned that there are specific guidelines for assigning DDD for pediatric population. Can you specify these? Are these pediatric DDDs used for drug utilization studies done for the community? Thanks. Best, Anita Kotwani

netrumgroups (DOT) comFrom: gharpurekunda@ .co. inDate: Fri, 4 Jan 2008 17:28:54 +0530Subject: ATC/DDD what we learnt--

Hello All ,

It was a good attempt by few ,at replying to my post, which showed that the posts are being read.

Let us now focus our attention on Defined Daily Dose. DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults It provides a unit of measurement enabling the researchers to assess trends in drug consumption and to perform comparisons between population groups. It is a unit of measurement and does not necessarily reflect the recommended or prescribed daily dose.

For topical products, sera, vaccines, anesthetics, anti- neoplastics, and contrast media DDDs are not established, because these doses are very diverse. There are specific guidelines for assigning DD to plain products combination medicines, fixed dose groups depot formulations and pediatric preparations.

It is emphasized here that DDD is nearly always a compromise based on a review of the available information on doses used in various countries.

There are different methods of presenting the data on drug utilization studies.

DDD per 1000 –mostly used for chronically used drugs.

DDD per 100 bed days.- used for hospital based drug utilization study where the bed occupancy is considered.

DDD per inhabitant per year- used for market statistics, indicates the utilization by every inhabitant during a certain year.

somehow use of ATC /DDD was not put forth with conviction at the TBS . So even I have doubts of its use in practical applications in research other than drug utilisation studies.

Sarang, I will try to reply to your question in my next post.

kunda

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