Re: “The role of PGNX in RUM” atten:Mangesh

[Guest guest]

Dear Dr Mangesh, Nice to see your brief and informative posting that clears various ideas about PGNX and its possible role in RUM. Regards, Dr Kiran Chaudhari Lecturer, Pharmacology, GMC, Nagpur mangesh bankar <drmangesh_bankar@...> wrote: According to a famous ancient quote “what is medicine to some may be the fierce poison to others.” The same drug and in the same dosage may produce beneficial effects in many patients but can produce adverse effects in few. We already have data regarding the number of hospital admissions and deaths due to adverse drug reactions. We also know that the most important factor for such variable response to medicines is the genetic differences between the individuals. Pharmacogenomics is the new field that is bridging the gap between pharmacology, drug treatment and the patients. Pharmacogenomics associates individual’s genetic make up with drug

metabolism and treatment response. It takes into consideration all the causes of differences in the drug response which includes genes controlling the drug metabolizing enzymes, transporter proteins, signaling and cellular response pathways and cellular targets. Pharmacogenomcis holds the promise to use the current drugs more rationally, finding of the new drug targets, and development of new drugs. Now, how the knowledge of the molecular action of drug and genetic determinants of the drug response is to going to achieve the goal of giving the right drug at the right dose to the right patient and at the right time(RUM)? By looking at the genetic profile of the patients, the genes responding to a given drug by over-expression, down-regulation or no response at all can be easily identified. So by this we can tell which are the genes involved in the drug response and expected side effects of the drug. Treatment strategies based on the population’s genetic profiles can be developed so that we can predict which are responders, non-responders and poor responders, also the patients who are prone to side effects. In conclusion, pharmacogenomics will be very helpful for the RUM: By looking at the genetic profile, best drug for the patient can be selected. Dosage adjustment can be made according to person’s genetics so avoiding the risk of adverse effects. Early selection of the optimal therapy will definitely increase the patient’s compliance to therapy. Regards Dr. Mangesh Nagpur Forgot the famous last words? Access your message archive online. Click here.

Chat on a cool, new interface. No download required. Click here.