A Pandemic That Wasn’t but Might Be

[Guest guest]

Last year, for the first time since avian flu emerged as a global

threat, the number of human cases was down from the year before. As

the illness receded, the scary headlines — with their warnings of a

pandemic that could kill 150 million people — all but vanished.

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But avian flu has not gone away. Nor has it become less lethal or less

widespread in birds. Experts argue that preparations against it have

to continue, even if the virus's failure to mutate into a pandemic

strain has given the world more breathing room.

There were 86 confirmed human cases last year compared with 115 in

2006, according to the World Health Organization, and 59 deaths

compared with 79. Experts assume that the real numbers are several

times larger, because many cases are missed, but that is still a far

cry from a pandemic.

Dr. Nabarro, the senior United Nations coordinator for human and

avian flu, recently conceded that he worried somewhat less than he did

three years ago. " Not because I think the threat has changed, " he

quickly added, but because the response to it has gotten so much better. "

The world is clearly more prepared. Vaccines have been developed.

Stockpiles of Tamiflu and masks have grown. Many countries, cities,

companies and schools have written pandemic plans. The European Center

for Disease Prevention and Control, created in Stockholm in 2005, just

estimated that the European Union needed " another two to three years

of hard work and investment " to be ready for a pandemic, but that is

improving because previous estimates were for five years.

In the worst-hit countries — all poor — laboratories have become

faster at flu tests. Government veterinarians now move more quickly to

cull chickens. Hospitals have wards for suspect patients, and

epidemiologists trace contacts and treat all with Tamiflu — a tactic

meant to encircle and snuff outbreaks before the virus can adapt

itself to humans.

Bernard Vallat, director general of the World Organization for Animal

Health, recently called the virus " extremely stable " and, thus, less

likely to mutate into a pandemic form. Many prominent virologists

would vehemently disagree. But others who argued three years ago that

H5N1 would not " go pandemic " are feeling a bit smug.

Dr. A. Offit, a vaccine specialist at Children's Hospital in

Philadelphia, was one of those who, he jokes, " dared to be stupid " by

bucking the alarmist trend in 2005.

" H5 viruses have been around for 100 years and never caused a pandemic

and probably never will, " he said.

But Dr. Offit said he backed all preparedness efforts because he

expected another pandemic from an H1, H2 or H3, the subtypes

responsible for six previous epidemics, including the catastrophic one

in 1918.

" What I worry is that this has been a `boy who cried wolf'

phenomenon, " he said. " When the next pandemic comes, people will say,

`Yeah, yeah, we heard that last time.' "

Some who were Cassandras in 2005 still are.

The fact that human cases fell slightly last year is " pretty much

meaningless, " argued T. Osterholm, director of the Center for

Infectious Disease Research and Policy at the University of Minnesota.

The virus is still circulating and has evolved 10 clades and hundreds

of variants.

World preparations thus far are " incremental, " he said, " like sending

10 troops to a war when you need 10,000. "

He noted that the H3N8 flu found in horses in the 1960s took 40 years

to adapt to dogs, but that since 2004 it has spread to kennels all

over the country.

The most worrisome aspect of H5N1, virtually all scientists agree, is

that it persists in birds without becoming less lethal to them.

" This is the most serious bird flu virus that has ever been known, "

Dr. Nabarro said. " By 2007, it was in 60 countries. It must be dealt

with. "

Despite the culling of hundreds of millions of birds and the injection

of billions of doses of poultry vaccine, the virus is out of control

in some of the most populous countries — though exactly which ones are

in dispute, because some are touchy about conceding that they cannot

rid their flocks of it.

Dr. Vallat has named three countries where it is now endemic in local

birds: Egypt, Indonesia and Nigeria.

Dr. Nabarro added Bangladesh, Vietnam and parts of China. Reports of

recurrent outbreaks also persist in parts of India, Myanmar and

Pakistan. Last week, villagers in India were reported to be killing

and eating their flocks before government cullers, who paid less than

a third of market value, could seize them.

Dr. Henry L. Niman, a biochemist in Pittsburgh whose Web site tracks

mutations, argues that there is a separate reservoir in wild birds

that extends across Eurasia. Late each fall, fresh outbreaks appear

across Europe and down into the Middle East as geese and swans migrate

from Asia toward Africa.

In December, dying birds were found in Poland and Russia, in Saudi

Arabia and even in a kindergarten petting zoo in Israel.

On Jan. 8, it reached one of England's most famous swan-breeding

grounds, the Abbotsbury Swannery, which has been around since the 11th

century.

The Western Hemisphere is in less danger, according to a study

published in the journal PloS Pathogens, which analyzed viruses found

in migratory birds sampled from 2001 to 2006 in Alberta and along the

Jersey Shore. It found that none carried whole viruses from Eurasian

bird pathways.

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Therefore, the authors argued, it is more likely that any importation

of the virus would be in " birds moved legally or illegally by humans. "

It may be even more likely that a human will be the first carrier.

There was a close call in early December, when six members of one

family in northern Pakistan fell ill, probably infected by a brother

who had culled sick poultry.

Another brother, who lived on Long Island, went to Pakistan for the

funeral and felt sick when he returned home. He turned out not to have

H5N1, but it showed how easily the virus could have reached the

Western Hemisphere.

Pakistan had its first human cases last year, as did Laos, Myanmar and

Nigeria.

Many small mutations have been recorded that seem to make the virus

more adaptable to humans and more resistant to known drugs, but no

combination of those producing a superstrain has yet emerged.

Ninety percent of cluster cases have been among blood relatives, and

Dr. Arnold S. Monto, an avian flu expert at the University of Michigan

School of Public Health, said that suggested a genetic susceptibility

that has not yet been defined.

It has long been known that the virus has difficulty attaching to

receptors in human noses. A team at M.I.T. has refined that, showing

that those receptors come in two shapes, cones and umbrellas, and that

avian viruses attach more easily to the cones.

Rapid progress has been made in vaccines. The newest, Dr. Monto said,

need just small amounts of antigen — 4 micrograms an injection instead

of 90 micrograms — making them much more practical to produce.

Some scientists argue for vaccinating millions of people as a

precaution. One dose, even if it is based on a three-year-old strain,

might protect against death, if not infection. A second, fully

protective dose could be made up from whatever strain has gone pandemic.

Right now, said Dr. Klaus Stöhr, who was chief of flu vaccines for the

W.H.O. and now does the same for Novartis, it would take manufacturers

about one year to produce a billion doses of any vaccine based on a

new pandemic strain. But the pandemic would have circled the globe

within three months.

" The peak would be over, and, principally, you'd be vaccinating

survivors, " Dr. Stöhr said. Switzerland, he added, has a vaccine

stockpile and plans to test it on soldiers, police officers and health

care workers before deciding whether to offer it to all Swiss.

Because of the American swine flu debacle of 1976, in which a vaccine

made against a pandemic that never emerged harmed more people than the

flu did, experts say they think it is unlikely that many Americans

would be willing to take such precautions.

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