US GAO report says drugs cannot delay flu pandemic

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Don't rely on drugs to delay flu pandemic

Wed Jan 23, 2008 12:32 AM GMT

WASHINGTON (Reuters) - Vaccines and drugs will not be enough to slow

or prevent a pandemic of influenza, according to a U.S. government

report released on Tuesday.

The report from the U.S. Government Accountability Office confirms

what most experts have been stressing for years -- that the

pharmaceutical industry cannot be relied on alone to protect the world

from bird flu.

The GAO, the investigational arm of Congress, reached its own

conclusion independently.

" The use of antivirals and vaccines to forestall the onset of a

pandemic would likely be constrained by their uncertain effectiveness

and limited availability, " the GAO report reads.

Health experts almost universally agree that a global epidemic -- a

pandemic -- of influenza is inevitable and even overdue. Flu is always

circulating but, every few decades, a completely new strain emerges

and makes millions sicker than usual.

One prime suspect is the H5N1 strain of avian influenza. It is

entrenched in poultry across much of Asia, the Middle East and Africa,

pops up regularly in Europe and has forced the slaughter of hundreds

of millions of birds.

It also occasionally infects people, killing 219 of the 351 people

infected in 14 countries since 2003.

Quick use of antiviral drugs, especially Roche AG and Gilead Sciences

Inc.'s Tamiflu, can save lives. A vaccine would also help, the GAO

report noted.

But supplies of both are low and a vaccine would have to be formulated

to match the precise strain causing a pandemic -- a process that

currently takes months.

Many countries have no way to even keep track of outbreaks, meaning

the virus could spread unnoticed.

" The delayed use of antivirals and the emergence of antiviral

resistance in influenza strains could limit their effectiveness, " the

GAO report said.

" Current antiviral production capacity is inadequate to reach the

number of antivirals WHO (World Health Organization) estimates will be

needed to contain a pandemic, " it added.

" Increasing global production capacity of vaccines and antivirals will

take several years as new production facilities are built, materials

necessary for production are acquired, and the necessary approval is

received to market these medical products in various countries. "

The U.S. Health and Human Services Department noted it has been aware

of all the issues raised by the GAO and said this is why its pandemic

plan includes other ways to limit the spread of a new virus, including

closing schools and promoting hygiene measures such as hand washing.

" Our preparations are broad and deep, " the Health and Human Services

Department said in its comment on the GAO report.

(Reporting by Maggie Fox, editing by O'Callaghan)

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