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Why people are confused about Flumist and H5N1

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The Wikipedia article says this about Flumist and H5N1:

" Flumist is designed to be quickly modifiable to present the surface

antigens of seasonal flu. The modifiability could also allow it to be

quickly customized as a vaccine against a pandemic influenza if one

were to emerge. In light of the Global spread of H5N1 advance

preparation to reduce human mortality in the event of an H5N1 pandemic

has begun. Modifying Flumist to serve as a specific human H5N1 vaccine

is among the measures studied.[20]

In June 2006, the National Institutes of Health (NIH) began enrolling

participants in a Phase 1 H5N1 study of an intranasal influenza

vaccine candidate based on MedImmune's live, attenuated vaccine

technology.[21]

In September 2006 the NIH NIAID reported that inoculation with a

Flumist vaccine modified to present the surface antigens of certain

H5N1 variants provided broad protection against other H5N1 variants in

the mouse and ferret models.[22] "

And I think that this is what has caused alarm among people who have a

weak understanding of the sciences of virology and molecular biology.

Not that I am an expert, but I haven taken some courses in molecular

biology and I do know that markers are not viruses and cannot spread

the disease for which they mark. A virus is a very complex particle,

of which the surface proteins are only one small piece.

The purpose of attaching surface components from H5N1, or any other

variant of influenza, to the surface of the Flumist virus is to signal

the immune system to develop a defense against the real thing, should

the person ever come in contact with it. But surface proteins cannot

cause the disease of the virus from which they are derived. In

Flumist these markers are attached to a weakened (attenuated) version

of a mild live influenza. The live attenuated virus is a delivery

mechanism to get the markers into the blood stream so that the immune

system can see them and react to them. Again, the markers cannot

cause the disease for which they mark.

It is understandable that people with no education in the very arcane

sciences of molecular biology or virology would misunderstand how

Flumist works, and become alarmed at the idea of inhaling any part of

H5N1. But hopefully people like mentalchemist, once they are

informed, will start to spread the word to others in his circle who

are similarly confused and stop spreading misinformation.

He should also think about what I said in an earlier post about the

impossibility of a company deliberately creating a pandemic to make

profit from it, due to, if nothing else, the huge number of people who

would have to agree to be complicit in a plan so horrible and criminal

that almost no one would think it was a good idea or, upon being

recruited, would refrain from blowing the whistle on the whole insane

idea. It really just can't happen.

And by the way, the article says that preparing H5N1 markers is just

being studied at this point, and has not happened.

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