Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 Anyone worried about osteopenia/osteoporosis should request a calcium blood test. They can tell whether you need a bone scan by your blood calcium. I was hyocalcemic and osteopenic with total calcium 2.23 down from 2.40 and corrected calcium level of 2.13, down from 2.23 (reference range 2.10 - 2.55). Just shows what damage a reduction of 50mcg thyroxine can do as not only did I have the hypo symptoms but also the added hypocalcemic symptoms which are very unpleasant. Chris > > > > - there are no studies to show that having a suppressed TSH > > when taking thyroid hormone replacement is a cause of osteoporosis. > > > > [Edit Abbrev Mod] > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 Hi , i am still having problems, mostly the adrenals which are closely connected to the thyroid. but don`t get treatment from a doctor at present. I am treating myself. but in the past way back in 1968 when I was 21 years old I married and got pregnant 2 months after which I thought was lucky, umm. not so lucky after all. had a miscarrage, then another one and a third one,. I then waited a year and had a little boy . six years after this had another boy both prem and small for time. they are aged 36 and 30. both have autistic problems. this is due to the auto-antibodies. as my tests are in the reference range my GP will not treat me, so I saw DR P in 1990. and it was he how diagnosed me hypothyroidism, but not hash`s, this group is great for support and I realised in 2006 that it may be hash`s ,so got the test done privately and the rest is history as they say.lol. hope things go well for you. regards angel. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 Hi You have had a dreadful time, but with the help of this site and Dr P, we DO get better. And yes, you are right the treatment (or rather mistreatment) of thyroid patients is shocking. Most GPs just don't have a clue. You are in the right place now! Good luck Pen x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 Thanks Pennny, I am going to call Dr P tomorrow, hopefully to get an appointment, obviously don't know how booked up he gets though..? x > > Hi > You have had a dreadful time, but with the help of this site and Dr P, > we DO get better. And yes, you are right the treatment (or rather > mistreatment) of thyroid patients is shocking. Most GPs just don't > have a clue. > You are in the right place now! > Good luck Pen x > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 Hi Sheila, I have had a bone scan and everything was fine, still the doctors were worried about my suppressed tsh levels. Also I didn't feel well on 150 mcgs and felt I needed more rather than less thyroxine. They reassured me that this was normal and convinced me to try less. I actually have felt better on a lower dose of thyroxine 100mcgs, the problems have come in a different disguise - two miscarriages. So now I don't know what my body needs...are there any endorcinologists that you could recommend? - I can travel from here..(Hay on Wye) Thanks emily > > - there are no studies to show that having a suppressed TSH when > taking thyroid hormone replacement is a cause of osteoporosis. Many women > who are menopausal can start to show signs of this disease. These doctors > should do a little more research and should be asked to cite references to > such cases. Your GP, if worried, should send you to have a bone scan done. > > > > luv - Sheila > > > > Hi Angel, > Thanks for that, isn't it interesting that the doctors were so concerened > about my supressed tsh, so much so that they just kept on at me to lower my > dose, otherwise I would get osteoporsis, they were quite worried about my > bone density, so we lowered the dose and then what ? I have two > miscarriages, presumably both are due to the antibodies...? I have learnt > lots and realise that I have probably been a bit passive and just listened a > lot to the professionals, thanks for the info though, yes what did we do > before the internet...? Are you well now? Do you take natural thyroid > extract? > _,_._,___ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 Sheila, You wrote: > > - there are no studies to show that having a suppressed TSH when > taking thyroid hormone replacement is a cause of osteoporosis.... Actually, there are, but suppression studies have been consistently based on suppression of TSH by T4 only medication. The most recent one showed that if TSH is held below 0.1 for three consecutive months, there is measurable bone loss and changes in cardiac muscle. That is the study that led to the recommendation to drop the lower end of the TSH reference range to 0.3 . Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 OK that explains things as mine was below 0.1 for a long time - years even. Where do you find these studies? On the internet? Thanks > > > > - there are no studies to show that having a suppressed TSH when > > taking thyroid hormone replacement is a cause of osteoporosis.... > > Actually, there are, but suppression studies have been consistently > based on suppression of TSH by T4 only medication. The most recent one > showed that if TSH is held below 0.1 for three consecutive months, there > is measurable bone loss and changes in cardiac muscle. That is the study > that led to the recommendation to drop the lower end of the TSH > reference range to 0.3 . > > Chuck > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2008 Report Share Posted December 7, 2008 , You wrote: > > > OK that explains things as mine was below 0.1 for a long time - years > even. Where do you find these studies? On the internet? This one was famous, because the lowered limit of the TSH reference range hinged on it. At work, I can get at least an abstract on every paper published through SciFinder, a library service from the American Chemical Society. However, Google Scholar is almost as good, if you take time to separate wheat from chaff. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2008 Report Share Posted December 8, 2008 Hi I am sending you a list of doctors in case you still need to find one in your area - or if you are prepared to travel. This will be sent by seperate post. Please will you remember to delete the messages you have already read before clicking 'SEND' and just leave a portion of what you are responding to. It makes it difficult if you don't do this for people who have opted to receive a 'Daily Digest' (with up to 25 messages in one email " or who read direct from the web site when they have to scroll through these to get to the next message. Luv - Sheila ______________________________________ I have noticed that Dr Peatfield runs a clinic in Malvern which is close...Thanks for the advice on temp etc - I am thinking of keeping a little record book of everything...I will get some up to date bloods done and post them with some of my old results.. > Thanks again > emily > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2008 Report Share Posted December 8, 2008 Chuck - will you post references to the studies you mention please. luv - Sheila Sheila, You wrote: > > - there are no studies to show that having a suppressed TSH when > taking thyroid hormone replacement is a cause of osteoporosis.... Actually, there are, but suppression studies have been consistently based on suppression of TSH by T4 only medication. The most recent one showed that if TSH is held below 0.1 for three consecutive months, there is measurable bone loss and changes in cardiac muscle. That is the study that led to the recommendation to drop the lower end of the TSH reference range to 0.3 . Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2008 Report Share Posted December 8, 2008 Hi Angel, Thanks for your story, I didn't know about the connection between anti bodies and autism, it seems there's lots I don't know!! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2008 Report Share Posted December 8, 2008 I have a friend at work who has taken thyroxine for years, she usually takes between 150mcg-200mcg a day, she has no thyroid it was removed. She started off hyper and then had the thyroid removed. Last year she actually broke a rib just by leaning over a seat on the school bus she was off for a long time while it healed. I am now wondering if all those years on Thyroxine has weakened her bones and thats why her rib broke so easily? Of course I doubt she knows nothing of armour and seems ok on thyroxine but it makes me wonder Anyone worried about osteopenia/osteopor osis should request a calcium blood test. They can tell whether you need a bone scan by your blood calcium.I was hyocalcemic and osteopenic with total calcium 2.23 down from 2.40 and corrected calcium level of 2.13, down from 2.23 (reference range 2.10 - 2.55).Just shows what damage a reduction of 50mcg thyroxine can do as not only did I have the hypo symptoms but also the added hypocalcemic symptoms which are very unpleasant.Chris> >> > - there are no studies to show that having a suppressed TSH> > when taking thyroid hormone replacement is a cause of osteoporosis.> > > > [Edit Abbrev Mod]> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 28, 2009 Report Share Posted February 28, 2009 Hi Ruth - I am so sorry to hear you are going through this as I remember how well you were doing. I had assumed you had gone away because you were continuing to do well and was just getting on with the business of living. You should ask to be tested for diabetes - some hypothyroids do develop diabetes. However, would your GP refer you to an endocrinologist as I think that would be best. Ask your GP to test your ferritin level, B12, Vitamin D, Zinc, Copper and Magnesium. Can you talk with Dr Peatfield on the phone as you are a patient of his and put him in the picture. I'm so sorry to offer such little information about what might be your problem that could help you right now, but as you get tested for various things, it should become clear about what road you need to travel. Luv - Sheila I had been coping very well with the stress of it all but beginning to wonder if i was kidding myself! My GP isn't that knowledgable about adrenals and thyroid, basically went along with what Dr P advised, so he might be clueless too when I see him monday. Anyone else experienced this on HC? Thanks in advance for any replies, Ruth Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 28, 2009 Report Share Posted February 28, 2009 Hi Ruth, I'm sorry you're having a stressful time of it. One needs to keep some reserve energy. 50 lengths twice a week may be a bit too much, with the other stressors thrown into the equation. Was that giving you a 'high' feeling ? High cortisol may cause euphoria if it gets out of hand. Running out of glycogen is a problem; that may have depleted some tissues and you can't now 'fill up' on glycogen (stored form of 'starch' in tissues). CFS has some/maybe all of the symptoms of low mitochondrial function ( mitochondria ~ energy producing units in the cells ). As suggested, look for insulin/diabetes problems or maybe pituitary/adrenal function too. Diabetes insipidus can cause lots of very dilute urine output. Of the two types of diabetes (mellitus/insipidus) the former type implies sugar in the urine, the latter type implies no 'taste' ie, insipid. Glucagon and insulin (sugar storage and use ) act in opposite directions ~ hence feeling hungry and thirsty is to be expected if the signallng system has faltered, but why; as you say, HC ~ too much or too little? best wishes, Bob > > Hi everyone, haven't been here for a while. I've been diagnosed > with adrenal fatigue and hypothyroidsm by Dr P last June, I took > NAE for a while, then added Nutri Thyroid, then started on Armour, > didn't tolerate the Armour well at all so started on > hydrocortisone. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Hi Ruth, I am really sorry to hear about all those problems. It is horrid when at first you do so well, and then all goes pearshaped. To add to what Sheila and Bob have already said, I would suggest you also check yourself for possible Candida albicans as the culprit (i.e. do the early morning spit-test - it's in the files), since taking cortisol can invite yeast overgrowth. Please get in touch with Dr. P. He is the best person to advise and make sense of what is happening to you. Best wishes, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Hi Ruth, have you been tested for diabetes .? why i ask is it sounds like all your symptomsmay be linked to it. get tested asap . angel. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2009 Report Share Posted March 2, 2009 Hi Ruth, Suggest you phone Dr. P- you maybe right about no longer needing the pred, but best check with him first. Have you had blood sugars checked- diabetes- just a thought. Subject: HELP! I have begun to feel very weak and tired, am extremely thirsty and hungry, although trying not to eat abnormal amounts. My weight loss has stalled also after doing really well, have swelling on my legs, ankles and belly some days, face looks puffy and have issues with blood sugar again, craving carbs. I am weeing all the time, but not at night for some reason, wee is clear like water. I also have weird bruises and getting new stretch marks. Looking at side effects, I'm guessing it's the HC, as in excess of it, , Ruth ------------------------------------ TPA is not medically qualified. Consult with a qualified medical practitioner before changing medication. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2009 Report Share Posted March 2, 2009 Hi Ruth Margaret here Just read your email.I feel exactly like you are describing every bit of it.I was tested for diabetes but was NORMAL .I had to leave work and go to bed it is one of the most awful feelings.At the time I was on 125mcg of Eltroxin and they would not up it so I cut a 25mcg in half and added 12.5mcg daily.I did this as I was so ill my gp told me to SUCK A MINT I was furious.With the increase all my hypoglicemia went.That was November.I have started on Armour a month ago and all these feelings have come back off and on and I think that is because I am obviosly not on stable meds yet as have to uup slowly.I have never taken HC so I know it wasnt that. Hope this helps Margaret From: Stenning <jennystenning@...>thyroid treatment Sent: Monday, March 2, 2009 12:04:13 PMSubject: RE: HELP!Subject: HELP!I have begun to feel very weak and tired, am extremely thirsty and hungry, although trying not to eat abnormal amounts. ------------------------------------TPA is not medically qualified. Consult with a qualified medicalpractitioner before changing medication. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 5, 2009 Report Share Posted March 5, 2009 Hello everyone, thank you for your replies. :-) I have been told I have a severe water infection and tried one antibiotic, had an allergic reaction to it, would be awkward! ha ha. Now on a different sort and have had no allergic reaction so far so good! After a discussion with GP thinking that my symptoms partly may be stressed out adrenals due to extra physical stress (not been right for weeks and quite probably have had water infection for 4 weeks but like an idiot left it till it got really bad coz took me a while to realise that it's not normal to go to loo 20 times a day ha ha), have upped HC to 30mg from 20mg whilst I'm ill. Having major issues with blood sugar I think, being so hungry and up and down with eating very 'adrenally', dizziness on standing also. I think maybe I am still a bit hypothyroid, hard to tell at the moment, but will need to speak to Dr P about it, last blood tests last year showed a high normal T3 and low normal T4 and supressed TSH (at 2 and a half grains i think) but temp still a bit low 36.3 c from 35.4c (before treatment), nearly there?, pulse before rising is 70 bpm. I am on three grains of Armour a day, my NHS GP thinks two ha ha, T3 is probably out of range now. It took me a while to get up to three grains because of adrenals, I have been on three grains of Armour for about 8 weeks now, I have noticed improvement of energy levels and for the most part maintained the other improvements like being warmer, eyes brighter, aches and pains mostly gone but my weight loss has completely stalled after losing nearly 4 stone in about 6 months, still got another 2 to lose to reach ideal weight, weight hasn't changed since beginning of year despite doing more exercise and eating really healthily. My face is still a bit puffy and I still get swollen ankles and legs and I've noticed my tongue is still swollen and scalloped, would of thought if I was on right dose would be normal by now? I still don't get up in the morning and feel awake ha ha so I'm not normal yet. I suppose I should speak to Dr P about it,I do wonder whether the T4/T3 ratio in the Armour is right for me as T4 was low normal and T3 high normal, thought supposed to both be high in range? I don't know, complicated business this is ha ha, thanks all for replies :-) XX > > Hi Ruth Margaret here > Just read your email.I feel exactly like you are describing every bit of it.I was tested for diabetes but was NORMAL .I had to leave work and go to bed it is one of the most awful feelings.At the time I was on 125mcg of Eltroxin and they would not up it so I cut a 25mcg in half and added 12.5mcg daily.I did this as I was so ill my gp told me to SUCK A MINT I was furious.With the increase all my hypoglicemia went.That was November.I have started on Armour a month ago and all these feelings have come back off and on and I think that is because I am obviosly not on stable meds yet as have to uup slowly.I have never taken HC so I know it wasnt that. > > Hope this helps > > Margaret > > > > > ________________________________ > From: Stenning <jennystenning@...> > thyroid treatment > Sent: Monday, March 2, 2009 12:04:13 PM > Subject: RE: HELP! > > > > > Subject: HELP! > I have begun to feel very > weak and tired, am extremely thirsty and hungry, although trying > not to eat abnormal amounts. > > ------------------------------------ > > TPA is not medically qualified. Consult with a qualified medical > practitioner before changing medication. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 6, 2009 Report Share Posted March 6, 2009 I would feel very tempted to add 25 mcgs to your Armour Ruth. There seems to be so much going on but obviously, there is something happening that has not been addressed. Your water infection will not be helping matters right now. Your blood sugar might have something do with your cortisol, and those taking this medication might be able to help you with this. Have you had your ferritin tested recently, B12, Vitamin D, magnesium, zinc and copper? Could you have Candida? Something stopping your thyroid hormone replacement from working as it should. You MUST speak with Dr P, so don't delay this. Luv - Sheila My face is still a bit puffy and I still get swollen ankles and legs and I've noticed my tongue is still swollen and scalloped, would of thought if I was on right dose would be normal by now? I still don't get up in the morning and feel awake ha ha so I'm not normal yet. I suppose I should speak to Dr P about it,I do wonder whether the T4/T3 ratio in the Armour is right for me as T4 was low normal and T3 high normal, thought supposed to both be high in range? I don't know, complicated business this is ha ha, thanks all for replies :-) XX Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 6, 2009 Report Share Posted March 6, 2009 Hi Sheila, thank you for reply. Do you mean add 25 mcgs of T4 to the Armour? I think maybe from previous blood tests and the urine test I have had done which have both shown low normal T4 but before treatment very low out of range T3 that may not be using the T3, may be pooling in my blood and not actually doing much, would make sense but have no idea why, could be adrenals, could be something else ha ha. I have not had vit D, magnesium or zinc tested, not sure about copper, had ferritin tested a while ago which was low, then again after starting ferrous sulphate and was much improved although not optimum, there was a big improvement after starting the Armour, have been slacking a bit taking the ferrous sulphate, will ask for another test to check how it is. I will try doing the spit test for candida tomorrow, antibiotics would not help in that area so taking high dosage of prebiotics and probiotics and eating live yogurt whilst taking them. Best plan I think is to talk to Dr P like you said and then tell my GP what he said ha ha, I'm lucky, he pretty much goes along with what Dr P says, although nervous ha ha and we're careful what goes in my notes. Trying to manage with GP and Dr P to sort things out as adding an endo would probably screw everything up! You're right, water infection won't be helping, nor is all the never ending crap going on around me at the moment ha ha but for the most part have maintained quiet dignity and stayed positive,wouldn't of been able to if I was still untreated so I'm very thankful for your input as you pointed me in the right direction, thank you. I hope to play a more active part in your campaign once I have my life sorted ha ha, one thing at a time :-) It would be great to be in perfect health, amoungst other things, to prove to my GP that Armour does work, and he was right to put his trust in me and Dr P and to question 'procedure', he finds me fascinating apparently ha ha, would love him to say he is prescribing Armour for other people, one can only hope ha ha xxx Thanks again xx > > I would feel very tempted to add 25 mcgs to your Armour Ruth. There seems to > be so much going on but obviously, there is something happening that has not > been addressed. Your water infection will not be helping matters right now. > Your blood sugar might have something do with your cortisol, and those > taking this medication might be able to help you with this. Have you had > your ferritin tested recently, B12, Vitamin D, magnesium, zinc and copper? > Could you have Candida? Something stopping your thyroid hormone replacement > from working as it should. You MUST speak with Dr P, so don't delay this. > > > > Luv - Sheila > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 6, 2009 Report Share Posted March 6, 2009 Problem is Ruth, we can go on and on and on saying… " it could be thios...or it could be that… " and not getting any better in the meantime. If there is a suspicion, then get the appropriate test done so you know whether or not it is this or that. We just cannot guess with this game. If the T3 was " pooling " you would be getting feelings of toxicity with palpitations, feeling very 'spaced out' sweating, dizziness, trembling and general shakiness etc. and yes, I did mean adding 25 mcgs T4 to see if that will help. I couldn't exist with this tiny amount I added to my Armour. I would forget about previous blood tests, what matters is what is going on now and finding the reasons you are showing the results you are. Please get your Vitamin D checked - this is SO important (Read the website information www.tpa-uk.org.uk and see the connection with low vitamin D and the effect it has on the thyroid. You will find this under Hypothyroidism and then Associated Conditions. Please also get your ferritin, zinc, copper, magnesium, B12 checked at the same time. There has to be no guess work here. You may find you still need to take ferrous sulphate - your ferritin needs to be between 70 and 90 for you to feel good and for your thyroid hormone to be able to work. The spit test is only an indication you might have Candida - it is not 100% positive that should your spit spread out like an octopus with threads floating towards the bottom of the glass means you have systemic candidiasis - but a damned good bet. You need to get tested to see if you have Candida antibodies if you feel this is a real possibility. Let us know what Dr P suggests. Luv - Sheila Trying to manage with GP and Dr P to sort things out as adding an endo would probably screw everything up! You're right, water infection won't be helping, nor is all the never ending crap going on around me at the moment ha ha but for the most part have maintained quiet dignity and stayed positive,wouldn't of been able to if I was still untreated so I'm very thankful for your input as you pointed me in the right direction, thank you. I hope to play a more active part in your campaign once I have my life sorted ha ha, one thing at a time :-) It would be great to be in perfect health, amoungst other things, to prove to my GP that Armour does work, and he was right to put his trust in me and Dr P and to question 'procedure', he finds me fascinating apparently ha ha, would love him to say he is prescribing Armour for other people, one can only hope ha ha xxx Thanks again xx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2009 Report Share Posted March 9, 2009 HI Lostgirl " Lowish FT4 and highish FT3 are normal for Armour I beg to differ with this remark. If FT4 is low with high FT3 when on 3 grains Armour I would strongly suspect that LOW Cortisol is causind FT3 pooling. I see you are on only 20mg HC I think that is too low a dose for anyone. On RTH & Hormone Support Group we see Women needing MINIMUM of 25mg HC & Men 30mg HC. Especially with the amount of exercise you were doing you would have been burning through the HC too. Were you stress dosing before the exercise? As regards to frequent copious weeling I strongly recommend you get Aldosterone, Renin, Salt & Potassium tested. Do you have low BP fast HR at all? Does BP drop or rise from sitting to standing? Systolic should consisitently rise at least 10 points. See my post here on how to correctly test thyroid treatment/message/35532 When was Potassuim & Sodium last tested & what were the results? Do you do Sea Salt supping at all? Have you tried increasing it to see if it reduces the peeing? Suboptimal & unbalanced electrolytes causes cellular dehydration, affects every body function & is a big stressor as well. Worth checking it out. If you are having blood sugar regulation problems that can be related to HC amount & dosing too. Not having ENOUGH will cause reactive Hypoglycemia & Insulin Resistance. Eating frequent small meals & having plenty of good quality fats & proteins will help with that. So will optimal DHEAS levels. Chromium Picolinate is also helpful in regulating Insulin levels as is ALA. " Armour as it contains more T3 than a healthy human would produce. Some of us need to balance it with a little thyroxine. " This is incorrect and an argument oft used by Endos to justify T4 only! See this article by Dr Ray Peat which points out that in fact that in fact the Thyroid produces at T3:T4 ratio of 1:3 even HIGHER than the 1:4 Armour & Dessicated Thyroid USP!!! +++++++++++++++++++++++++++++++++++++++++++++++++++ Thyroid: Therapies, Confusion and Fraud excerpt http://raypeat.com/articles/articles/thyroid.shtml Years ago it was reported that Armour thyroid, U.S.P., released T3 and T4, when digested, in a ratio of 1:3, and that people who used it had much higher ratios of T3 to T4 in their serum, than people who took only thyroxine. The argument was made that thyroxine was superior to thyroid U.S.P., without explaining the significance of the fact that HEALTHY PEOPLE WHO WEREN'T TAKING ANY THYROID SUPPLEMENT HAD HIGHER T3:T4 RATIOS THAN THE PEOPLE WHO TOOK THYROXINE, or that OUR OWN THYROID GLAND RELEASES A HIGH RATIO OF T3 TO T4. The fact that the T3 IS BEING USED FASTER THAN T4, REMOVING IT FROM THE BLOOD MORE QUICKLY THAN IT ENTERS FROM THE THYROID GLAND ITSELF, hasn't been discussed in the journals, possibly because it would support the view that a natural glandular balance was more appropriate to supplement than pure thyroxine. The SERUM'S HIGH RATIO OF T4 TO T3 is a pitifully poor argument to justify the use of thyroxine INSTEAD OF A PRODUCT THAT RESEMBLES THE PROPORTION OF THESE SUBSTANCES SECRETED BY A HEALTHY THYROID GLAND, OR MAINTAINED INSIDE CELLS. About 30 years ago, when many people still thought of thyroxine as " the thryoid hormone, " someone was making the argument that " the thyroid hormone " must work exclusively as an activator of genes, since most of the organ slices he tested didn't increase their oxygen consumption when it was added. In fact, the ADDITION OF THYROXINE TO BRAIN SLICES SUPPRESSED THEIR RESPIRATION BY 6% during the experiment. Since most T3 is produced from T4 in the liver, not in the brain, I think that experiment had great significance, despite the ignorant interpretation of the author. AN EXCESS OF THYROXINE, IN A TISSUE THAT DOESN'T CONVERT IT RAPIDLY TO T3, HAS AN ANTITHYROID ACTION. (SEE GOUMAZ, ET AL, 1987.) THIS HAPPENS IN MANY WOMEN WHO ARE GIVEN THYROXINE; AS THEIR DOSE IS INCREASED, THEIR SYMPTOMS GET WORSE. The brain concentrates T3 from the serum, and may have a concentration 6 times higher than the serum (Goumaz, et al., 1987), and it can achieve a higher concentration of T3 than T4. It takes up and concentrates T3, while tending to expel T4. REVERSE T3 (RT3) DOESN'T HAVE MUCH ABILITY TO ENTER THE BRAIN, BUT INCREASED T4 CAN CAUSE IT TO BE PRODUCED IN THE BRAIN. These observations suggest to me that the blood's T3:T4 ratio would be very " brain favorable " if it approached more closely to the ratio formed in the thyroid gland, and secreted into the blood. Although most synthetic combination thyroid products now use a ratio of four T4 to one T3, many people feel that their memory and thinking are clearer when they take a ratio of about three to one. MORE ACTIVE METABOLISM PROBABLY KEEPS THE BLOOD RATIO OF T3 TO T4 RELATIVELY HIGH, with the liver consuming T4 at about the same rate that T3 is used. Since T3 has a short half life, it should be taken frequently. If the liver isn't producing a noticeable amount of T3, it is usually helpful to take a few micrograms per hour. Since it restores respiration and metabolic efficiency very quickly, it isn't usually necessary to take it every hour or two, but until normal temperature and pulse have been achieved and stabilized, sometimes it's necessary to take it four or more times during the day. T4 acts by being changed to T3, so it tends to accumulate in the body, and on a given dose, usually reaches a steady concentration after about two weeks. An effective way to use supplements is to take a combination T4-T3 dose, e.g., 40 mcg of T4 and 10 mcg of T3 once a day, and to use a few mcg of T3 at other times in the day. Keeping a 14-day chart of pulse rate and temperature allows you to see whether the dose is producing the desired response. If the figures aren't increasing at all after a few days, the dose can be increased, until a gradual daily increment can be seen, moving toward the goal at the rate of about 1/14 per day +++++++++++++++++++++++++++++++++++++++++++++++++++++++ Lethal Lee Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2009 Report Share Posted April 10, 2009 Hello everyone, thanks for your replies. I spoke to Dr P briefly last week, forgot to tell him about the needing to wee alot as my GP was so sure it was a UTI but lab results never showed any bacteria (only one dipstick did), but here I am 6 weeks of feeling like I need to wee all the time and having taken 5 courses of various antibiotics have got no where. They have told me to 'go away and see if things settle down', the usual fobbing off they do coz they haven't got a clue what to do with me. Meanwhile, it may sound dramatic but it's ruining my life and the school runs aren't fun coz I have to walk. Dr P recommended I increase the HC to 30 mg which I have done, he said a low normal T4 and high T3 was OK, although T3 would definately be well over range now as that was when I was on 2 grains Armour and now on 3 and a half. Could adrenals be the cause of the constant feeling that I need to urinate? Looking on the net, could be low aldosterone but does that cause more frequent urination than the constant discomfort I'm experiencing? I am drinking lots as always thirsty BUT according to my scales that show water/muscle/fat ratio as well as weight, I am well below the normal range for water which I guess means I'm dehydrated and I feel dehydrated with the headaches and thirst. I'm also putting on weight after doing so well I'm reluctant to go back to GP unless I know exactly what to suggest, they did say they should do but blood tests but when I asked what tests they didn't know, probably just humouring me ha ha. I have seen three GPs about the needing to wee all the time, none of them have come up with anything other than handing me antibiotics and as usual I'm having to do the thinking. If there is a chance it's adrenal-related I will go back and demand they do tests but need to have some idea which ones. Dr P is unavailable till the 14th so can't ask him. I have been having sea salt, if they test sodium will probably be normal coz I've also realised I'm having loads of marmite and soy sauce and I HATE anything salty, deliberately avoid salt ha ha. I'm so tired and fed up. My blood pressure is fine, rises as it should but then it always has, but my pulse still shoots up from 70 to 120 just by standing up so feel dizzy. I feel better in the evenings after the mid afternoonn slump which i have to drag myself through. Main question is can adrenals cause the feeling like I need to wee all the time? Thanks in advance for any replies.XX > > HI Lostgirl > > " Lowish FT4 and highish FT3 are normal for Armour > I beg to differ with this remark. If FT4 is low with high FT3 when on 3 grains Armour I would strongly suspect that LOW Cortisol is causind FT3 pooling. > > I see you are on only 20mg HC I think that is too low a dose for anyone. On RTH & Hormone Support Group we see Women needing MINIMUM of 25mg HC & Men 30mg HC. > > Especially with the amount of exercise you were doing you would have been burning through the HC too. Were you stress dosing before the exercise? > > As regards to frequent copious weeling I strongly recommend you get Aldosterone, Renin, Salt & Potassium tested. Do you have low BP fast HR at all? Does BP drop or rise from sitting to standing? Systolic should consisitently rise at least 10 points. > > See my post here on how to correctly test > thyroid treatment/message/35532 > > When was Potassuim & Sodium last tested & what were the results? > Do you do Sea Salt supping at all? Have you tried increasing it to see if it reduces the peeing? > > Suboptimal & unbalanced electrolytes causes cellular dehydration, affects every body function & is a big stressor as well. Worth checking it out. > > If you are having blood sugar regulation problems that can be Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2009 Report Share Posted April 10, 2009 Your frequent need for urination could be low aldosterone. Those folk with low aldosterone are unable to retain sodium, and it spills into the bladder, taking water with it. This results in frequent urination, dehydration, and heat intolerance. Electrolytes become imbalanced, resulting in muscle twitches, heart palpitations, and the pupils of the eyes are unable to stay “constricted” when subjected to light (they “flutter”) - check this out Ruth. Check out Dr Lam's web site on Adrenals - this guy is one of the best, and follow its links to learn more about aldosterone, and how to treat it. http://www.drlam.com/articles/adrenal_fatigue.asp Also, reading Dr Thierry Hertoghe's " The Hormone Handbook " he states " Complaints of Aldosterone Deficiency " How does a person with aldosterone deficiency feel? Typical, individuals with aldosterone deficiency have low blood pressure. The lack of aldosterone, the principal salt-and-water-retaining hormone, makes the patient lose a great deal of fluid in the urine. Because of the low blood pressure, the blood and thus nutrient and oxygen supply does not reach the brain of a person with low blood pressure well, particularly when the person stands up, making the patient feel drowsy and absent-minded. The principle complaints suggestive of aldosterone deficiency are: Behaviour: Tendency to lie down. Tendency to move all the time when standing up to increase blood pressure. Concentration: Drowsiness - xombie-like feeling. Easily distracted, absent-minded. Day dreaming. Difficulty focusing on tasks. Feels better in head when lying flat on a bed or moving all the time. Vision: Troubled vision with difficulties in focusing on objects and tasks when standing up Food: Salt and salty food cravings. Thirsty often, strong tendency to drinking a lot of water and other liquids. Urine: Polyuria, especially during the day. Does this sound like it could be your problem Ruth? Luv - Sheila Hello everyone, thanks for your replies. I spoke to Dr P briefly last week, forgot to tell him about the needing to wee alot as my GP was so sure it was a UTI but lab results never showed any bacteria (only one dipstick did), but here I am 6 weeks of feeling like I need to wee all the time and having taken 5 courses of various antibiotics have got no where. They have told me to 'go away and see if things settle down', the usual fobbing off they do coz they haven't got a clue what to do with me. Meanwhile, it may sound dramatic but it's ruining my life and the school runs aren't fun coz I have to walk. Dr P recommended I increase the HC to 30 mg which I have done, he said a low normal T4 and high T3 was OK, although T3 would definately be well over range now as that was when I was on 2 grains Armour and now on 3 and a half. Could adrenals be the cause of the constant feeling that I need to urinate? Looking on the net, could be low aldosterone but does that cause more frequent urination than the constant discomfort I'm experiencing? I am drinking lots as always thirsty BUT according to my scales that show water/muscle/fat ratio as well as weight, I am well below the normal range for water which I guess means I'm dehydrated and I feel dehydrated with the headaches and thirst. I'm also putting on weight after doing so well I'm reluctant to go back to GP unless I know exactly what to suggest, they did say they should do but blood tests but when I asked what tests they didn't know, probably just humouring me ha ha. I have seen three GPs about the needing to wee all the time, none of them have come up with anything other than handing me antibiotics and as usual I'm having to do the thinking. If there is a chance it's adrenal-related I will go back and demand they do tests but need to have some idea which ones. Dr P is unavailable till the 14th so can't ask him. I have been having sea salt, if they test sodium will probably be normal coz I've also realised I'm having loads of marmite and soy sauce and I HATE anything salty, deliberately avoid salt ha ha. I'm so tired and fed up. My blood pressure is fine, rises as it should but then it always has, but my pulse still shoots up from 70 to 120 just by standing up so feel dizzy. I feel better in the evenings after the mid afternoonn slump which i have to drag myself through. Main question is can adrenals cause the feeling like I need to wee all the time? Thanks in advance for any replies.XX > > HI Lostgirl > > " Lowish FT4 and highish FT3 are normal for Armour > I beg to differ with this remark. If FT4 is low with high FT3 when on 3 grains Armour I would strongly suspect that LOW Cortisol is causind FT3 pooling. > > I see you are on only 20mg HC I think that is too low a dose for anyone. On RTH & Hormone Support Group we see Women needing MINIMUM of 25mg HC & Men 30mg HC. > > Especially with the amount of exercise you were doing you would have been burning through the HC too. Were you stress dosing before the exercise? > > As regards to frequent copious weeling I strongly recommend you get Aldosterone, Renin, Salt & Potassium tested. Do you have low BP fast HR at all? Does BP drop or rise from sitting to standing? Systolic should consisitently rise at least 10 points. > > See my post here on how to correctly test > thyroid treatment/message/35532 > > When was Potassuim & Sodium last tested & what were the results? > Do you do Sea Salt supping at all? Have you tried increasing it to see if it reduces the peeing? > > Suboptimal & unbalanced electrolytes causes cellular dehydration, affects every body function & is a big stressor as well. Worth checking it out. > > If you are having blood sugar regulation problems that can be Quote Link to comment Share on other sites More sharing options...
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