Guest guest Posted August 21, 2008 Report Share Posted August 21, 2008 Does anyone have any information about when Effirma (oral flupirtine) might be available in the U.S.A.? thanks " Live well and feel good " ... http://chronicfatigue.about.com/od/latestresearch/a/effirmaforfibro.htm Prospective Fibromyalgia Drug Offers Long Track Record, Few Side Effects A new fibromyalgia drug could be on he horizon, and this one has a long history of use for pain with only mild side effects and no chance of addiction. Effirma (oral flupirtine) is the drug, and it's not an opiate, an antidepressant or an anti-seizure medication, which makes it substantively different from other drugs used to treat fibromyalgia syndrome (FMS). " The process for getting drugs approved in the United States is a long one, so even if trials show it is a safe and effective treatment for FMS, it could be years before Effirma is on the market. " http://chronicfatigue.about.com/od/latestresearch/a/effirmaforfibro.htm From another web page,,, " Oral flupirtine has been approved as a treatment of pain in Europe since 1981 but has never been approval for any indication in the U.S. Flupirtine, a non-opiate analgesic, has been used in Europe for more than 25 years for post-surgical pain, cancer pain, trauma pain, pain associated with liver disease, and other nocioceptive pain states. Preclinical data and clinical experience suggests that flupirtine should also be effective for neuropathic pain since it acts in the central nervous system. Flupirtine is especially attractive because it operates through non-opiate pain pathways, exhibits no known abuse potential, and lacks withdrawal effects. In addition, no tolerance to its antinocioceptive effects has been observed. One common link between neuroprotection, nocioception, and flupirtine may be the NMDA (N-methyl-D-aspartate) glutamate system, a major receptor subtype for the excitotoxic neurotransmitter, glutamate. Flupirtine has strong inhibitory actions on NMDA-mediated neurotransmission. " Its a sad thing that it takes so long for " new " meds to reach the market. Even with a 25 year track record in other parts of the world. " Live well and feel good " ... Quote Link to comment Share on other sites More sharing options...
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