genetics HIV treatment summary

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This is what I mean by findings that show results in a non-equivocal way. it

summarizes a test where patients own T cells were removed, altered regrown to

large numbers, and re-injected, immune to, or highly resistive to, HIV

infection. Based on original " Berlin Patient " , this has been scaled to mass

production already, pending further testing. Gates has funded a study to

determine if it can be done with ONE procedure inside the patient, clinically.

Check this out.

from Sangamo biosciences:

Summary of Clinical Data

The data demonstrate that a single infusion of SB-728-T was well tolerated; the

CCR5-modified cells successfully engrafted in all subjects and resulted in a

durable improvement in total CD4+ T-cell counts in five of six of the subjects

analyzed. In addition, five of the six subjects also exhibited sustained

improvements in their CD4:CD8 T-cell ratio, which is an indicator of immunologic

health. The ZFN-CCR5-modified cells also exhibited normal T-cell growth kinetics

and trafficking and were observed to undergo selective expansion in the gut

mucosa, a major reservoir of virus in the body, suggesting, as predicted, that

the cells were resistant to HIV infection. These data represent the necessary

first steps in the development of a " functional cure " for HIV/AIDS by providing

a protected CD4+ T-cell population in these subjects that is resistant to HIV

infection.

bG