Safer than Statins

[Guest guest]

Syntrinol, a natural supplement, was developed after 12 years of

extensive research on the cardiovascular effects of polymethoyxlated

flavonoids (nobiletin and tangeretin) and tocotrienols. The health

benefits of the three ingredients have been demonstrated in in-vitro

and in-vivo, and currently underway is a long-term, double-blind,

crossover randomized study involving 120 men and women with

moderately elevated cholesterol levels [>230mg/dL] taking 150mg of

Syntrinol twice a day.

What I find most interesting about these two flavonoids -- which are

derived from the peels of oranges, tangerines and other citrus fruits

that aren't in our normal diet -- besides their ability to lower the

dangerous small particle LDL (apolipoprotein- [as well as the other

lipid markers, of course], is their powerful anti-inflammation

activity in inhibiting nitric oxide and superoxide production, as

well as downregulating COX-2 without interfering with COX-1

expression (Vioxx). [PMID: 15303543, PMID: 15137829, PMID: 15070159,

PMID: 14662111, PMID: 7495469, PMID: 1562270, PMID: 2265479, PMID:

2515664, PMID: 3139283, PMID: 3128399, PMID: 7448777]

Tocotrienols, natural analogs of tocopherols, do degrade the HMG-CoA

reductase enzyme, have power anti-inflammatory effects, and raise

apolipoprotein-A/decrease apolipoprotein-B. [PMID: 15005643, PMID:

15209019, PMID: 14639121, PMID: 11975364, PMID: 11882333]. These

facts could help explain why the widely recognized Vitamin E

supplements, alpha tocopherol or mixed tocopherols, don't have much

of an impact in studies.

Science has now recognized that the inflammation process is a

facilitator of many diseases (I would personally say ALL), including

artherosclerosis. As I've mentioned before, total cholesterol and

LDL is popularized propaganda only because it is an easy target the

drug companies can cook-up something for, but it is not the most

important factor in prevention. In fact, statins only reduce the

risk of dying from a heart attack by a pathetic 30% and only over a 5

year time frame [PMID: 9576425]. It does nothing to cure the

disease. And by association, probably neither will Syntrinol. But

given the side effects of statins which include muscle wasting, liver

dysfunction and rhabdomyolysis, Syntrinol appears a heck of a lot

safer!

I'm not going to be eating citrus peels anytime soon, but I am making

a switch to a natural Vitamin E supplement containing both mixed

tocopherols AND tocotrienols. NOW Foods has an excellent one

called " Gamma E Complex " that doesn't cost an arm and a leg.

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