Rhesus monkeys' CR

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From: " old542000 " <apater@m...>

Date: Fri Oct 29, 2004 8:45 pm

Subject: Rhesus monkeys' CR

The DR monkeys were maintained on monkey chow

(Purina Mills), which was calorically titrated on an

individual monkey basis to maintain a goal weight of 10

to 11 kg, the weight of normal lean adult monkeys (19).

This body weight is associated with a body fat ranging

from approximately 17–24% (16,19,24). Each monkey was

weighed a minimum of once weekly, and the individual

daily chow allotment was adjusted up or down for each

monkey depending on any change in its body weight. This

caloric titration usually required an increase or decrease of

one to two biscuits per day.

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I found it interesting that CR was controlled using the body weight of

lean monkeys as reference, rather than calories in the diet. The

system of diet adjustment based on weekly weightings seems very

practical. In humans males, 17-24% Body Fat falls in the " Fitness "

(14%-17%) and " Acceptable " (18%-25%) categories, rather than in the

" athlete " category (6%-13% BF).

It seems significant that just maintaining a lean frame decreases the

risk of death. " Results showed the risk of death for an AL fed monkey

was 2.6-fold higher than the risk of death for a DR monkey

of the same age. "

The results imply that humans keeping %BF in the 15% range would

already have a lower risk of death, but we knew that, didn't we?

However, it is nice to know that you don't have to get down to 5% BF

to enjoy the benefits.

Tony