Melanoma and UV radiation

[Guest guest]

Hi All,

We try to get some vitamin D from our exposure to the UV radiation

from the sun.

What are the risk-benefits of such a strategy.

To me, the pdf-available below suggests my cover-up strategy is in

order.

Again, there is benefits to viewing the pdf above and beyond that

for our

viewing of the Medline abstract below.

A case in point, is the data of Table 1.

For:

Table 1 .Odds ratios (ORs) of melanoma by demographic,

anthropometric,and sun-exposure factors

For increasing age in men and women the p for trend = <0.001 and

0.02,

respectively.

Also, for increasing sunburns at age 11-20, the p for = trend

<0.001 and

0.001. This seems to be the age at which exposure, often resulting

in

sunburn for me and others.

The increasing tendency to burn p for trend = <0.001 for both

sexes.

Decrease in ability to tan values were 0.004 and 0.05.

Hair color at age 15 for from Dark brown/black > Light brown >

Blond >

Red p for trends = <0.001 and <0.001.

Increasing freckles at age 20 values were p for trend = <0.001 and

<0.001.

Cancer Causes Control. 2004 Nov;15(9):893-902.

Melanoma and lifetime UV radiation.

CC, White E, Kristal AR, Vaughan T.

... this case-control study

... Cases were 386 patients between the ages of 35 and 74 who

were diagnosed with primary cutaneous melanoma within the Seattle-

Puget Sound

area during 1997. Controls were 727 participants of the same age and

geographic

area, selected by random-digit dialing. A telephone interview ...

odds ratios

(OR) and 95 confidence intervals (CI) reflecting the risk of melanoma

associated

with UV exposure, after adjustment for age, sex, income, tendency to

burn and

sunburns during ages 2-10. Results : Among women, lifetime UV

exposure was

associated with melanoma risk (adjusted OR=1.99 for highest versus

lowest

quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were

significant trends

for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02).

Among men,

there were no significant associations at any time period, but

lifetime UV

exposure was associated with higher risk for men who had a tendency

toward

severe or painful sunburns (OR= 2.85 for highest versus lowest

quartile, 95 CI:

0.84-9.64, p for trend=0.04).

Conclusion : ... it may be useful to target those with a higher

sensitivity to the

sun when formulating messages for prevention of melanoma by

lowering exposure to UV.

PMID: 15577291 [PubMed - as supplied by publisher]

[Guest guest]

The point, I think has been lost. is that skin cancer develops from sun exposure in the past, like in youth. Something I have no control over.

And maybe we needed that sunburning at age 10 to ward off PCa? (I have no idea).

So what is risk of exposure now at age, to beef up serum vit d? I can't totally avoid the sun in Texas, as you cannot see the sun for maybe several months in Canada. But Canadians could use a sun lamp for say 15 mins.

Regards.

----- Original Message -----

From: old542000

Sent: Thursday, December 09, 2004 6:59 PM

Subject: [ ] Melanoma and UV radiation

Hi All, We try to get some vitamin D from our exposure to the UV radiation fromthe sun. What are the risk-benefits of such a strategy. To me, the pdf-available below suggests my cover-up strategy is in order. Again, there is benefits to viewing the pdf above and beyond that for ourviewing of the Medline abstract below. A case in point, is the data of Table 1. For: Table 1 .Odds ratios (ORs) of melanoma by demographic,anthropometric,and sun-exposure factors For increasing age in men and women the p for trend = <0.001 and 0.02,respectively. Also, for increasing sunburns at age 11-20, the p for = trend <0.001 and0.001. This seems to be the age at which exposure, often resulting insunburn for me and others. The increasing tendency to burn p for trend = <0.001 for both sexes. Decrease in ability to tan values were 0.004 and 0.05. Hair color at age 15 for from Dark brown/black > Light brown > Blond >Red p for trends = <0.001 and <0.001. Increasing freckles at age 20 values were p for trend = <0.001 and<0.001. Cancer Causes Control. 2004 Nov;15(9):893-902.Melanoma and lifetime UV radiation. CC, White E, Kristal AR, Vaughan T. ... this case-control study... Cases were 386 patients between the ages of 35 and 74 whowere diagnosed with primary cutaneous melanoma within the Seattle-PugetSoundarea during 1997. Controls were 727 participants of the same age andgeographicarea, selected by random-digit dialing. A telephone interview ... oddsratios(OR) and 95 confidence intervals (CI) reflecting the risk of melanomaassociatedwith UV exposure, after adjustment for age, sex, income, tendency to burnandsunburns during ages 2-10. Results : Among women, lifetime UV exposure wasassociated with melanoma risk (adjusted OR=1.99 for highest versus lowestquartile, 95 CI: 0.95-3.03, p for trend=0.008). There were significanttrendsfor UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). Among men,there were no significant associations at any time period, but lifetime UVexposure was associated with higher risk for men who had a tendency towardsevere or painful sunburns (OR= 2.85 for highest versus lowest quartile, 95CI:0.84-9.64, p for trend=0.04).Conclusion : ... it may be useful to target those with a higher sensitivityto thesun when formulating messages for prevention of melanoma bylowering exposure to UV. PMID: 15577291 [PubMed - as supplied by publisher]Cheers, Alan Pater

[Guest guest]

And Alan's article said there's a diff in those with sensitive skin.

"Conclusion : ... it may be useful to target those with a higher > > sensitivity> > to the> > sun when formulating messages for prevention of melanoma by> > lowering exposure to UV."

Maybe the diff between pops that get PCa versus not.

Regards.

----- Original Message -----

From: Rodney

Sent: Friday, December 10, 2004 9:55 AM

Subject: [ ] Re: Melanoma and UV radiation

Hi folks:This is interesting on melanoma, and quite provocative since it suggests that heavy occupational exposure to sunlight REDUCES risk. (Unless I misunderstood?):"Melanoma and sun exposure: an overview of published studies.Elwood JM, Jopson J.Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, New Zealand. melwood@...To assess the association between the incidence of cutaneous melanoma; intermittent, occupational and total sun exposure; and history of sunburn at different ages, we conducted a systematic review using results of all published case-control studies which have assessed incident melanoma, sun exposure and sunburn. Twenty-nine studies contributed data on sun exposure and 21 on sunburn. Overall, there was a significant positive association (odds ratio [OR] = 1.71) for intermittent exposure, a significantly reduced risk for heavy occupational exposure (OR = 0.86) and a small, marginally significant excess risk for total exposure (OR = 1.18). There was a significantly increased risk with sunburn at all ages or in adult life (OR = 1.91) and similarly elevated relative risks for sunburn in adolescence (OR = 1.73) and in childhood (OR = 1.95). There was significant heterogeneity with all of these estimates except that of all ages or adult sunburn. These results show the specificity of the positive association between melanoma risk and intermittent sun exposure, in contrast to a reduced risk with high levels of occupational exposure. The association with sunburn also is likely to reflect intermittent exposure; the results do not suggest any strong relationship to age at sunburn. These associations are similar to those reported for basal cell skin cancer but different from those reported for squamous cell cancer. The mechanisms by which intermittent exposure increases risk, while other patterns of exposure do not, remain to be elucidated.PMID: 9335442 [PubMed - indexed for MEDLINE]"Rodney.> > > > The point, I think has been lost. is that skin cancer develops from sun> > exposure in the past, like in youth. Something I have no control over. > > And maybe we needed that sunburning at age 10 to ward off PCa? (I have no> > idea). > > > > So what is risk of exposure now at age, to beef up serum vit d? I can't> > totally avoid the sun in Texas, as you cannot see the sun for maybe several> > months in Canada. But Canadians could use a sun lamp for say 15 mins. > > > > Regards.> > > > > > > > > > ----- Original Message ----- > > From: old542000 > > > > Sent: Thursday, December 09, 2004 6:59 PM > > Subject: [ ] Melanoma and UV radiation > > > > > > Hi All,> > > > We try to get some vitamin D from our exposure to the UV radiation > > from> > the sun.> > > > What are the risk-benefits of such a strategy.> > > > To me, the pdf-available below suggests my cover-up strategy is in > > order.> > > > Again, there is benefits to viewing the pdf above and beyond that > > for our> > viewing of the Medline abstract below.> > > > A case in point, is the data of Table 1.> > > > For:> > > > Table 1 .Odds ratios (ORs) of melanoma by demographic,> > anthropometric,and sun-exposure factors> > > > For increasing age in men and women the p for trend = <0.001 and > > 0.02,> > respectively.> > > > Also, for increasing sunburns at age 11-20, the p for = trend > > <0.001 and> > 0.001. This seems to be the age at which exposure, often resulting in> > sunburn for me and others.> > > > The increasing tendency to burn p for trend = <0.001 for both > > sexes.> > > > Decrease in ability to tan values were 0.004 and 0.05.> > > > Hair color at age 15 for from Dark brown/black > Light brown > > > Blond >> > Red p for trends = <0.001 and <0.001.> > > > Increasing freckles at age 20 values were p for trend = <0.001 and> > <0.001.> > > > Cancer Causes Control. 2004 Nov;15(9):893-902.> > Melanoma and lifetime UV radiation.> > CC, White E, Kristal AR, Vaughan T.> > > > ... this case-control study> > ... Cases were 386 patients between the ages of 35 and 74 who> > were diagnosed with primary cutaneous melanoma within the Seattle-> > Puget> > Sound> > area during 1997. Controls were 727 participants of the same age and> > geographic> > area, selected by random-digit dialing. A telephone interview ... odds> > ratios> > (OR) and 95 confidence intervals (CI) reflecting the risk of melanoma> > associated> > with UV exposure, after adjustment for age, sex, income, tendency to > > burn> > and> > sunburns during ages 2-10. Results : Among women, lifetime UV > > exposure was> > associated with melanoma risk (adjusted OR=1.99 for highest versus > > lowest> > quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were significant> > trends> > for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). > > Among men,> > there were no significant associations at any time period, but > > lifetime UV> > exposure was associated with higher risk for men who had a tendency > > toward> > severe or painful sunburns (OR= 2.85 for highest versus lowest > > quartile, 95> > CI:> > 0.84-9.64, p for trend=0.04).> > Conclusion : ... it may be useful to target those with a higher > > sensitivity> > to the> > sun when formulating messages for prevention of melanoma by> > lowering exposure to UV.> > PMID: 15577291 [PubMed - as supplied by publisher]> > > > > > Cheers, Alan Pater> > > > > > > >