Blood sugar and prostate cancer

[Guest guest]

Hi All,

How do our blood sugars play a role in prostate

cancer risk seems to be answered " positively " in

the below.

Please see the not yet in Medline pdf-available

below.

Int J Cancer, 2004, 112, iss. 2, 446-450,Oct 10.

Glycemic index, glycemic load and risk of

prostate cancer

Livia S.A. Augustin, Carlotta Galeone, Luigino

Dal Maso, Claudio Pelucchi, Valerio Ramazzotti,

J.A. , Maurizio Montella, Renato

Talamini, Eva Negri, Silvia Franceschi, Carlo La

Vecchia

Dietary carbohydrates have different glycemic

and insulinemic potentials depending on type

(glycemic index, GI) and amount (glycemic load, GL)

of carbohydrate consumed or both. Insulin in turn

has been implicated as a risk factor for several

cancers, including that of the prostate. We

assessed the relationship of GI and GL with prostate

cancer risk in a multicenter case-control study.

Cases and controls were recruited between 1991 and

2002 in the network of major teaching and general

hospitals in 4 Italian areas. Cases were 1,204

men (age range 46-74 years) admitted for incident,

histologically confirmed prostate cancer.

Controls were 1,352 men (age range 46-74 years) admitted

for acute, nonmalignant conditions unrelated to

long-term modifications of diet. ORs of prostate

cancer and the corresponding 95% CIs were derived

using unconditional multiple logistic regression,

including terms for age, study center, education,

family history of prostate cancer, smoking, body

mass index,

physical activity, alcohol consumption, intake

of energy, fiber and lycopenes. Compared to the

lowest quintile of GI, the ORs were 1.23, 1.24,

1.47 and 1.57 for subsequent levels of GI. The

corresponding values for GL were 0.91, 1.00, 1.20 and

1.41. No heterogeneity was found among strata of

selected covariates. We found direct relations

between dietary GI and GL and prostate cancer risk.

Correcting for potential confounding factors did

not substantially modify these associations.

Cheers, Alan Pater