Re: Mutated EBV discovered in Russia

[Guest guest]

Dr. Marc- Fluks

[CO-CURE] RES,NOT: Mutated EBV discovered in Russia

ME/CFS and Fibromyalgia Information Exchange Forum [CO-CURE@...]

Sun 30/11/2008 1:13 AM

Source: NewsRx.com

Date: November 28, 2008

URL: http://www.newsrx.com/articles/1341755.html

Medline: http://www.ncbi.nlm.nih.gov/pubmed/18991560

Scientists at Russian Academy of Medical Science describe research in Epstein-Barr virus

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(NewsRx.com) -- Investigators publish new data in the report 'Functionally significant mutations in the Epstein-Barr virus LMP1 gene and their role in activation of cell signaling pathways.' "Latent membrane protein 1

(LMP1) of the Epstein-Barr virus is a constitutively activated analog of the tumor necrosis factor receptor TNF-R1. LMP1 serves as a viral oncogene able to transform human B-lymphocytes and rodent fibroblasts via activation of numerous cellular signal cascades," scientists writing in the journal Biochemistry report.

"Two specific motifs within LMP1 are responsible for interaction of this viral protein with the receptor protein beta-TrCP/HOS SCF of the ubiquitin ligase E3 complex, playing an important role in degradation of numerous cellular proteins including NF-kappaB inhibitor IkappaBalpha. In this study, we demonstrate for the first time the importance of point mutations affecting HOS-recognizing motifs of LMP1 for activation of NF-kappaB, AP1, and PI3K/Akt signaling pathways. It has also been shown that rat fibroblast cell lines (Rat-1) expressing different HOS mutants of LMP1 produce different amounts of reactive nitrogen species," wrote S.V. Diduk and colleagues, Russian Academy of Medical Science.

The researchers concluded: "Our data confirm the hypothesis that point mutations in the C-terminal region of the LMP1 cytoplasmic domain can influence the transforming potential of the Epstein-Barr virus."

Diduk and colleagues published their study in Biochemistry (Functionally significant mutations in the Epstein-Barr virus LMP1 gene and their role in activation of cell signaling pathways. Biochemistry, 2008;73(10):1134-9).

Additional information can be obtained by contacting S.V. Diduk, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia.

The publisher of the journal Biochemistry can be contacted at: Maik Nauka, Interperiodica, C, O Kluwer Academic-Plenum Publishers, 233 Spring St., New York, NY 10013-1578, USA.

Keywords: Russia, Biochemistry, Chronic Fatigue Syndrome, EBV, Enzyme Research, Epstein-Barr Virus, Herpes, Herpesvirus, Ligase, Necrosis, Viral, Virology.

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© 2008 NewsRx.com

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