Re: Pomegranate juice consumption for 3 years reduces carotid intima-media thickness

[Guest guest]

Hi Chuinyun:

Interesting study. Unfortunately though, the use of the

expression: " ... by up to 30% ... " makes it sound like a sales

pitch. Among any study group some will show little effect and others

a much larger effect than the average, perhaps because of entirely

unrelated factors.

So, whether this was financed by the Pomegranate producers or not,

the mean reduction would have been more persuasive to me, fwiw.

But look, a very interesting study if it is truly unbiased and well

conducted. Thanks for posting it.

Rodney.

--- In , " chuinyun " <chuinyun@a...>

wrote:

>

> Greeting! I present small study but important! Pomegranate very good

> for health. Anyone give pdf? Many thanks! Live long life!

>

> Pomegranate juice consumption for 3 years by patients with carotid

> artery stenosis reduces common carotid intima-media thickness, blood

> pressure and LDL oxidation

>

> AviramCorresponding Author Contact Information, E-mail The

> Corresponding Author, a, Mira Rosenblata, Gaitinib, Samy

> Niteckic, Hoffmanc, Dornfeldd, maltese maltese cross,

> Nina Volkovaa, Dita Pressera, Judith Attiasa, Harley Likerd and Tony

> Hayeka

>

> a The Lipid Research Laboratory, Rappaport Family Institute for

> Research in the Medical Sciences, Rambam Medical Center, Haifa

31096,

> Israel

> b The Department of Diagnostic Radiology, Rambam Medical Center,

> Haifa, Israel

> c The Department of Vascular and Transplantation Surgery, Technion

> Faculty of Medicine and Rambam Medical Center, Haifa, Israel

> d Geffen School of Medicine at UCLA, LA, USA

>

> Received 11 June 2003; accepted 7 October 2003. Available online

26

> November 2003.

>

>

> Abstract

>

> Dietary supplementation with polyphenolic antioxidants to animals

was

> shown to be associated with inhibition of LDL oxidation and

macrophage

> foam cell formation, and attenuation of atherosclerosis development.

>

> We investigated the effects of pomegranate juice (PJ, which contains

> potent tannins and anthocyanins) consumption by atherosclerotic

> patients with carotid artery stenosis (CAS) on the progression of

> carotid lesions and changes in oxidative stress and blood pressure.

>

> Ten patients were supplemented with PJ for 1 year and five of them

> continued for up to 3 years. Blood samples were collected before

> treatment and during PJ consumption. In the control group that did

not

> consume PJ, common carotid intima-media thickness (IMT) increased by

> 9% during 1 year, whereas, PJ consumption resulted in a significant

> IMT reduction, by up to 30%, after 1 year. The patients' serum

> paraoxonase 1 (PON 1) activity was increased by 83%, whereas serum

LDL

> basal oxidative state and LDL susceptibility to copper ion-induced

> oxidation were both significantly reduced, by 90% and 59%,

> respectively, after 12 months of PJ consumption, compared to values

> obtained before PJ consumption. Furthermore, serum levels of

> antibodies against oxidized LDL were decreased by 19%, and in

parallel

> serum total antioxidant status (TAS) was increased by 130% after 1

> year of PJ consumption. Systolic blood pressure was reduced after 1

> year of PJ consumption by 21% and was not further reduced along 3

> years of PJ consumption. For all studied parameters, the maximal

> effects were observed after 1 year of PJ consumption. Further

> consumption of PJ, for up to 3 years, had no additional beneficial

> effects on IMT and serum PON1 activity, whereas serum lipid

> peroxidation was further reduced by up to 16% after 3 years of PJ

> consumption.

>

> The results of the present study thus suggest that PJ consumption by

> patients with CAS decreases carotid IMT and systolic blood pressure

> and these effects could be related to the potent antioxidant

> characteristics of PJ polyphenols.

>

> Author Keywords: Lipoproteins; Lipid peroxidation; Atherosclerosis;

> Carotid ultrasound; Antioxidants; Pomegranate; Paraoxonase

[Guest guest]

Hi All,

Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L,

Volkova

N, Presser D, Attias J, Liker H, Hayek T.

Pomegranate juice consumption for 3 years by patients with carotid

artery

stenosis reduces common carotid intima-media thickness, blood

pressure and LDL

oxidation.

Clin Nutr. 2004 Jun;23(3):423-33.

PMID: 15158307 [PubMed - indexed for MEDLINE]

Yes, if you request directly at:

Cheers, Alan Pater, PhD; 4849 Swanson St., Port Alberni, BC, V9Y 6M7;

phone: 250 724-0596; email: old542000@...

--- In , " chuinyun " <chuinyun@a...>

wrote:

>

> Greeting! I present small study but important! Pomegranate very good

> for health. Anyone give pdf? Many thanks! Live long life!

>

> Pomegranate juice consumption for 3 years by patients with carotid

> artery stenosis reduces common carotid intima-media thickness, blood

> pressure and LDL oxidation

>

> AviramCorresponding Author Contact Information, E-mail The

> Corresponding Author, a, Mira Rosenblata, Gaitinib, Samy

> Niteckic, Hoffmanc, Dornfeldd, maltese maltese cross,

> Nina Volkovaa, Dita Pressera, Judith Attiasa, Harley Likerd and Tony

> Hayeka

>

> a The Lipid Research Laboratory, Rappaport Family Institute for

> Research in the Medical Sciences, Rambam Medical Center, Haifa

31096,

> Israel

> b The Department of Diagnostic Radiology, Rambam Medical Center,

> Haifa, Israel

> c The Department of Vascular and Transplantation Surgery, Technion

> Faculty of Medicine and Rambam Medical Center, Haifa, Israel

> d Geffen School of Medicine at UCLA, LA, USA

>

> Received 11 June 2003; accepted 7 October 2003. Available online

26

> November 2003.

>

>

> Abstract

>

> Dietary supplementation with polyphenolic antioxidants to animals

was

> shown to be associated with inhibition of LDL oxidation and

macrophage

> foam cell formation, and attenuation of atherosclerosis development.

>

> We investigated the effects of pomegranate juice (PJ, which contains

> potent tannins and anthocyanins) consumption by atherosclerotic

> patients with carotid artery stenosis (CAS) on the progression of

> carotid lesions and changes in oxidative stress and blood pressure.

>

> Ten patients were supplemented with PJ for 1 year and five of them

> continued for up to 3 years. Blood samples were collected before

> treatment and during PJ consumption. In the control group that did

not

> consume PJ, common carotid intima-media thickness (IMT) increased by

> 9% during 1 year, whereas, PJ consumption resulted in a significant

> IMT reduction, by up to 30%, after 1 year. The patients' serum

> paraoxonase 1 (PON 1) activity was increased by 83%, whereas serum

LDL

> basal oxidative state and LDL susceptibility to copper ion-induced

> oxidation were both significantly reduced, by 90% and 59%,

> respectively, after 12 months of PJ consumption, compared to values

> obtained before PJ consumption. Furthermore, serum levels of

> antibodies against oxidized LDL were decreased by 19%, and in

parallel

> serum total antioxidant status (TAS) was increased by 130% after 1

> year of PJ consumption. Systolic blood pressure was reduced after 1

> year of PJ consumption by 21% and was not further reduced along 3

> years of PJ consumption. For all studied parameters, the maximal

> effects were observed after 1 year of PJ consumption. Further

> consumption of PJ, for up to 3 years, had no additional beneficial

> effects on IMT and serum PON1 activity, whereas serum lipid

> peroxidation was further reduced by up to 16% after 3 years of PJ

> consumption.

>

> The results of the present study thus suggest that PJ consumption by

> patients with CAS decreases carotid IMT and systolic blood pressure

> and these effects could be related to the potent antioxidant

> characteristics of PJ polyphenols.

>

> Author Keywords: Lipoproteins; Lipid peroxidation; Atherosclerosis;

> Carotid ultrasound; Antioxidants; Pomegranate; Paraoxonase

[Guest guest]

Hi All,

For your information:

Results

Mean intima-media thickness (IMT) of the left and

right common carotid arteries from severe carotid

artery stenosis (CAS) patients that did not consume

pomegranate juice (PJ), increased significantly

(Po0.01), by 9%, during 1 year period from

1.5270.03 to 1.6570.04 mm. In contrast, mean

IMT (of the left and right common carotid arteries)

in CAS patients that consumed PJ for up to 1 year

was reduced after 3, 6, 9 and 12 months of PJ

consumption by 13%, 22%, 26% and 35%, respec-tively,

in comparison to baseline values (``0 time,

Fig. 1A).

Aviram

a,

*, Mira Rosenblat

a

, Gaitini

b

, Samy Nitecki

c

,

Hoffman

c

, Dornfeld

d,{

, Nina Volkova

a

, Dita Presser

a

,

Judith Attias

a

, Harley Liker

d

, Tony Hayek

a

a The Lipid Research Laboratory, Rappaport Family Institute for

Research in the Medical Sciences, Rambam

Medical Center, Haifa 31096, Israel

b The Department of Diagnostic Radiology, Rambam Medical Center,

Haifa, Israel

c The Department of Vascular and Transplantation Surgery, Technion

Faculty of Medicine and Rambam

Medical Center, Haifa, Israel

d

Geffen School of Medicine at UCLA, LA, USA

> >

> > Greeting! I present small study but important! Pomegranate very

good

> > for health. Anyone give pdf? Many thanks! Live long life!

> >

> > Pomegranate juice consumption for 3 years by patients with carotid

> > artery stenosis reduces common carotid intima-media thickness,

blood

> > pressure and LDL oxidation

> >

> > AviramCorresponding Author Contact Information, E-mail The

> > Corresponding Author, a, Mira Rosenblata, Gaitinib, Samy

> > Niteckic, Hoffmanc, Dornfeldd, maltese maltese cross,

> > Nina Volkovaa, Dita Pressera, Judith Attiasa, Harley Likerd and

Tony

> > Hayeka

> >

> > a The Lipid Research Laboratory, Rappaport Family Institute for

> > Research in the Medical Sciences, Rambam Medical Center, Haifa

> 31096,

> > Israel

> > b The Department of Diagnostic Radiology, Rambam Medical Center,

> > Haifa, Israel

> > c The Department of Vascular and Transplantation Surgery, Technion

> > Faculty of Medicine and Rambam Medical Center, Haifa, Israel

> > d Geffen School of Medicine at UCLA, LA, USA

> >

> > Received 11 June 2003; accepted 7 October 2003. Available

online

> 26

> > November 2003.

> >

> >

> > Abstract

> >

> > Dietary supplementation with polyphenolic antioxidants to animals

> was

> > shown to be associated with inhibition of LDL oxidation and

> macrophage

> > foam cell formation, and attenuation of atherosclerosis

development.

> >

> > We investigated the effects of pomegranate juice (PJ, which

contains

> > potent tannins and anthocyanins) consumption by atherosclerotic

> > patients with carotid artery stenosis (CAS) on the progression of

> > carotid lesions and changes in oxidative stress and blood

pressure.

> >

> > Ten patients were supplemented with PJ for 1 year and five of them

> > continued for up to 3 years. Blood samples were collected before

> > treatment and during PJ consumption. In the control group that

did

> not

> > consume PJ, common carotid intima-media thickness (IMT) increased

by

> > 9% during 1 year, whereas, PJ consumption resulted in a

significant

> > IMT reduction, by up to 30%, after 1 year. The patients' serum

> > paraoxonase 1 (PON 1) activity was increased by 83%, whereas

serum

> LDL

> > basal oxidative state and LDL susceptibility to copper ion-induced

> > oxidation were both significantly reduced, by 90% and 59%,

> > respectively, after 12 months of PJ consumption, compared to

values

> > obtained before PJ consumption. Furthermore, serum levels of

> > antibodies against oxidized LDL were decreased by 19%, and in

> parallel

> > serum total antioxidant status (TAS) was increased by 130% after 1

> > year of PJ consumption. Systolic blood pressure was reduced after

1

> > year of PJ consumption by 21% and was not further reduced along 3

> > years of PJ consumption. For all studied parameters, the maximal

> > effects were observed after 1 year of PJ consumption. Further

> > consumption of PJ, for up to 3 years, had no additional beneficial

> > effects on IMT and serum PON1 activity, whereas serum lipid

> > peroxidation was further reduced by up to 16% after 3 years of PJ

> > consumption.

> >

> > The results of the present study thus suggest that PJ consumption

by

> > patients with CAS decreases carotid IMT and systolic blood

pressure

> > and these effects could be related to the potent antioxidant

> > characteristics of PJ polyphenols.

> >

> > Author Keywords: Lipoproteins; Lipid peroxidation;

Atherosclerosis;

> > Carotid ultrasound; Antioxidants; Pomegranate; Paraoxonase

[Guest guest]

Hi folks:

Those are pretty remarkable numbers. Since a perfectly clean carotid

IMT still has significant thickness I would have thought that a 35%

reduction in thickness must be getting pretty darned close to being

completely cleaned out?

Astonishing, if accurate and generally applies to most/all subjects.

Rodney.

> > >

> > > Greeting! I present small study but important! Pomegranate very

> good

> > > for health. Anyone give pdf? Many thanks! Live long life!

> > >

> > > Pomegranate juice consumption for 3 years by patients with

carotid

> > > artery stenosis reduces common carotid intima-media thickness,

> blood

> > > pressure and LDL oxidation

> > >

> > > AviramCorresponding Author Contact Information, E-mail

The

> > > Corresponding Author, a, Mira Rosenblata, Gaitinib, Samy

> > > Niteckic, Hoffmanc, Dornfeldd, maltese maltese

cross,

> > > Nina Volkovaa, Dita Pressera, Judith Attiasa, Harley Likerd and

> Tony

> > > Hayeka

> > >

> > > a The Lipid Research Laboratory, Rappaport Family Institute for

> > > Research in the Medical Sciences, Rambam Medical Center, Haifa

> > 31096,

> > > Israel

> > > b The Department of Diagnostic Radiology, Rambam Medical Center,

> > > Haifa, Israel

> > > c The Department of Vascular and Transplantation Surgery,

Technion

> > > Faculty of Medicine and Rambam Medical Center, Haifa, Israel

> > > d Geffen School of Medicine at UCLA, LA, USA

> > >

> > > Received 11 June 2003; accepted 7 October 2003. Available

> online

> > 26

> > > November 2003.

> > >

> > >

> > > Abstract

> > >

> > > Dietary supplementation with polyphenolic antioxidants to

animals

> > was

> > > shown to be associated with inhibition of LDL oxidation and

> > macrophage

> > > foam cell formation, and attenuation of atherosclerosis

> development.

> > >

> > > We investigated the effects of pomegranate juice (PJ, which

> contains

> > > potent tannins and anthocyanins) consumption by atherosclerotic

> > > patients with carotid artery stenosis (CAS) on the progression

of

> > > carotid lesions and changes in oxidative stress and blood

> pressure.

> > >

> > > Ten patients were supplemented with PJ for 1 year and five of

them

> > > continued for up to 3 years. Blood samples were collected before

> > > treatment and during PJ consumption. In the control group that

> did

> > not

> > > consume PJ, common carotid intima-media thickness (IMT)

increased

> by

> > > 9% during 1 year, whereas, PJ consumption resulted in a

> significant

> > > IMT reduction, by up to 30%, after 1 year. The patients' serum

> > > paraoxonase 1 (PON 1) activity was increased by 83%, whereas

> serum

> > LDL

> > > basal oxidative state and LDL susceptibility to copper ion-

induced

> > > oxidation were both significantly reduced, by 90% and 59%,

> > > respectively, after 12 months of PJ consumption, compared to

> values

> > > obtained before PJ consumption. Furthermore, serum levels of

> > > antibodies against oxidized LDL were decreased by 19%, and in

> > parallel

> > > serum total antioxidant status (TAS) was increased by 130%

after 1

> > > year of PJ consumption. Systolic blood pressure was reduced

after

> 1

> > > year of PJ consumption by 21% and was not further reduced along

3

> > > years of PJ consumption. For all studied parameters, the maximal

> > > effects were observed after 1 year of PJ consumption. Further

> > > consumption of PJ, for up to 3 years, had no additional

beneficial

> > > effects on IMT and serum PON1 activity, whereas serum lipid

> > > peroxidation was further reduced by up to 16% after 3 years of

PJ

> > > consumption.

> > >

> > > The results of the present study thus suggest that PJ

consumption

> by

> > > patients with CAS decreases carotid IMT and systolic blood

> pressure

> > > and these effects could be related to the potent antioxidant

> > > characteristics of PJ polyphenols.

> > >

> > > Author Keywords: Lipoproteins; Lipid peroxidation;

> Atherosclerosis;

> > > Carotid ultrasound; Antioxidants; Pomegranate; Paraoxonase