Guest guest Posted January 24, 2005 Report Share Posted January 24, 2005 Prediction of Cardiovascular Mortality in Middle-aged Men by Dietary and Serum Linoleic and Polyunsaturated Fatty Acids E. Laaksonen, MD, PhD, MPH; Kristiina Nyyssönen, PhD; Leo Niskanen, MD, PhD; Tiina H. Rissanen, PhD; Jukka T. Salonen, MD, PhD, MScPH Arch Intern Med. 2005;165:193-199. Background Substitution of dietary polyunsaturated for saturated fat has long been recommended for the primary prevention of cardiovascular disease (CVD), but only a few prospective cohort studies have provided support for this advice. Methods We assessed the association of dietary linoleic and total polyunsaturated fatty acid (PUFA) intake with cardiovascular and overall mortality in a population-based cohort of 1551 middle-aged men. Dietary fat composition was estimated with a 4-day food record and serum fatty acid composition. Results During the 15-year follow-up, 78 men died of CVD and 225 of any cause. Total fat intake was not related to CVD or overall mortality. Men with an energy-adjusted dietary intake of linoleic acid (relative risk [RR] 0.39; 95% confidence interval [CI], 0.21-0.71) and PUFA (RR, 0.38; 95% CI, 0.20-0.70) in the upper third were less likely to die of CVD than men with intake in the lower third after adjustment for age. Multivariate adjustment weakened the association somewhat. Mortality from CVD was also lower for men with proportions of serum esterified linoleic acid (RR, 0.42; 95% CI, 0.21-0.80) and PUFA (RR, 0.25; 95% CI, 0.12-0.50) in the upper vs lower third, with some attenuation in multivariate analyses. Serum and to a lesser extent dietary linoleic acid and PUFA were also inversely associated with overall mortality. Conclusions Dietary polyunsaturated and more specifically linoleic fatty acid intake may have a substantial cardioprotective benefit that is also reflected in overall mortality. Dietary fat quality seems more important than fat quantity in the reduction of cardiovascular mortality in men. ****************************************************************************The contents of this email and any attachments are confidential. It isintended for the named recipient(s) only. If you have received this email inerror please notify the sender immediately Do not disclose it's contents toanyone and do not make copies.** This email has been scanned for viruses ****************************************************************************** Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2005 Report Share Posted January 24, 2005 This was an interesting abstract. It strengthens the discussions that we had some time ago about the Hegsted equation and the role of dietary linoleic acid (C18:2) in decreasing serum cholesterol. The best sources of linoleic acid are Safflower oil (78%), grape seed oil (73%), and sunflower oil (68%). By comparison, Canola oil and olive oil have 22% and 10% LA, respectively. About 50% of the weight of raw sunflower seeds consists of oil, which makes them make an excellent whole-food source of LA. Tony >>> From: " Jeff Novick " <jnovick@p...> Date: Mon Jan 24, 2005 4:36 pm Subject: EFAs and CVD Prediction of Cardiovascular Mortality in Middle-aged Men by Dietary and Serum Linoleic and Polyunsaturated Fatty Acids E. Laaksonen, MD, PhD, MPH; Kristiina Nyyssönen, PhD; Leo Niskanen, MD, PhD; Tiina H. Rissanen, PhD; Jukka T. Salonen, MD, PhD, MScPH Arch Intern Med. 2005;165:193-199. >>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2005 Report Share Posted January 25, 2005 And safflower doesn't freeze solid if you keep it in the refridgerator. Rodney. > > This was an interesting abstract. It strengthens the discussions that > we had some time ago about the Hegsted equation and the role of > dietary linoleic acid (C18:2) in decreasing serum cholesterol. > > The best sources of linoleic acid are Safflower oil (78%), grape seed > oil (73%), and sunflower oil (68%). By comparison, Canola oil and > olive oil have 22% and 10% LA, respectively. > > About 50% of the weight of raw sunflower seeds consists of oil, which > makes them make an excellent whole-food source of LA. > > Tony > > >>> > From: " Jeff Novick " <jnovick@p...> > Date: Mon Jan 24, 2005 4:36 pm > Subject: EFAs and CVD > > Prediction of Cardiovascular Mortality in Middle-aged Men by Dietary > and Serum Linoleic and Polyunsaturated Fatty Acids > E. Laaksonen, MD, PhD, MPH; Kristiina Nyyssönen, PhD; Leo > Niskanen, MD, PhD; Tiina H. Rissanen, PhD; Jukka T. Salonen, MD, PhD, > MScPH > Arch Intern Med. 2005;165:193-199. > >>> Quote Link to comment Share on other sites More sharing options...
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