Guest guest Posted January 7, 2005 Report Share Posted January 7, 2005 Pomegrate, fish oil, garlic, low sodium: Clin Nutr. 2004 Jun;23(3):423-33. Related Articles, Links Click here to read Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T. The Lipid Research Laboratory, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel. aviram@... Dietary supplementation with polyphenolic antioxidants to animals was shown to be associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development. We investigated the effects of pomegranate juice (PJ, which contains potent tannins and anthocyanins) consumption by atherosclerotic patients with carotid artery stenosis (CAS) on the progression of carotid lesions and changes in oxidative stress and blood pressure. Ten patients were supplemented with PJ for 1 year and five of them continued for up to 3 years. Blood samples were collected before treatment and during PJ consumption. In the control group that did not consume PJ, common carotid intima-media thickness (IMT) increased by 9% during 1 year, whereas, PJ consumption resulted in a significant IMT reduction, by up to 30%, after 1 year. The patients' serum paraoxonase 1 (PON 1) activity was increased by 83%, whereas serum LDL basal oxidative state and LDL susceptibility to copper ion-induced oxidation were both significantly reduced, by 90% and 59%, respectively, after 12 months of PJ consumption, compared to values obtained before PJ consumption. Furthermore, serum levels of antibodies against oxidized LDL were decreased by 19%, and in parallel serum total antioxidant status (TAS) was increased by 130% after 1 year of PJ consumption. Systolic blood pressure was reduced after 1 year of PJ consumption by 21% and was not further reduced along 3 years of PJ consumption. For all studied parameters, the maximal effects were observed after 1 year of PJ consumption. Further consumption of PJ, for up to 3 years, had no additional beneficial effects on IMT and serum PON1 activity, whereas serum lipid peroxidation was further reduced by up to 16% after 3 years of PJ consumption. The results of the present study thus suggest that PJ consumption by patients with CAS decreases carotid IMT and systolic blood pressure and these effects could be related to the potent antioxidant characteristics of PJ polyphenols. PMID: 15158307 [PubMed - indexed for MEDLINE] And so on...... On Fri, 07 Jan 2005 22:09:43 -0000, radioreceiver2003 <radioreceiver2003@...> wrote: > > > Hi, > > Some time back, the polymeal was discussed. > > Here is the actual article which was printed in the British Medical > Journal: http://bmj.bmjjournals.com/cgi/content/full/329/7480/1447 > > At the end of the article is an interesting section called rapid > responses. > > Actually, BMJ is an overall good publication to bookmark. > > One related question: what does the group suggest in terms of diet > and nutrition to bring down stubbornly moderately high blood pressure? > > Best Regards, > > Rad > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2005 Report Share Posted January 7, 2005 DASH: http://www.mckinley.uiuc.edu/health-info/dis-cond/bloodpr/dash-1500.html On Fri, 7 Jan 2005 17:15:40 -0500, Dowling <christopher.a.dowling@...> wrote: > Pomegrate, fish oil, garlic, low sodium: > > Clin Nutr. 2004 Jun;23(3):423-33. Related Articles, Links > Click here to read > Pomegranate juice consumption for 3 years by patients with carotid > artery stenosis reduces common carotid intima-media thickness, blood > pressure and LDL oxidation. > > Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld > L, Volkova N, Presser D, Attias J, Liker H, Hayek T. > > The Lipid Research Laboratory, Rappaport Family Institute for > Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, > Israel. aviram@... > > Dietary supplementation with polyphenolic antioxidants to animals > was shown to be associated with inhibition of LDL oxidation and > macrophage foam cell formation, and attenuation of atherosclerosis > development. We investigated the effects of pomegranate juice (PJ, > which contains potent tannins and anthocyanins) consumption by > atherosclerotic patients with carotid artery stenosis (CAS) on the > progression of carotid lesions and changes in oxidative stress and > blood pressure. Ten patients were supplemented with PJ for 1 year and > five of them continued for up to 3 years. Blood samples were collected > before treatment and during PJ consumption. In the control group that > did not consume PJ, common carotid intima-media thickness (IMT) > increased by 9% during 1 year, whereas, PJ consumption resulted in a > significant IMT reduction, by up to 30%, after 1 year. The patients' > serum paraoxonase 1 (PON 1) activity was increased by 83%, whereas > serum LDL basal oxidative state and LDL susceptibility to copper > ion-induced oxidation were both significantly reduced, by 90% and 59%, > respectively, after 12 months of PJ consumption, compared to values > obtained before PJ consumption. Furthermore, serum levels of > antibodies against oxidized LDL were decreased by 19%, and in parallel > serum total antioxidant status (TAS) was increased by 130% after 1 > year of PJ consumption. Systolic blood pressure was reduced after 1 > year of PJ consumption by 21% and was not further reduced along 3 > years of PJ consumption. For all studied parameters, the maximal > effects were observed after 1 year of PJ consumption. Further > consumption of PJ, for up to 3 years, had no additional beneficial > effects on IMT and serum PON1 activity, whereas serum lipid > peroxidation was further reduced by up to 16% after 3 years of PJ > consumption. The results of the present study thus suggest that PJ > consumption by patients with CAS decreases carotid IMT and systolic > blood pressure and these effects could be related to the potent > antioxidant characteristics of PJ polyphenols. > > PMID: 15158307 [PubMed - indexed for MEDLINE] > > And so on...... > > > On Fri, 07 Jan 2005 22:09:43 -0000, radioreceiver2003 > <radioreceiver2003@...> wrote: > > > > > > Hi, > > > > Some time back, the polymeal was discussed. > > > > Here is the actual article which was printed in the British Medical > > Journal: http://bmj.bmjjournals.com/cgi/content/full/329/7480/1447 > > > > At the end of the article is an interesting section called rapid > > responses. > > > > Actually, BMJ is an overall good publication to bookmark. > > > > One related question: what does the group suggest in terms of diet > > and nutrition to bring down stubbornly moderately high blood pressure? > > > > Best Regards, > > > > Rad > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2005 Report Share Posted January 7, 2005 Hi I think that you are on the same wavelength as the radioreceiver. Concerning your blood pressure lowering recommendations, it is very interesting but I started drinking pomegranate juice regularly two weeks ago - about 2 liters a week. I also started taking everyday 2 fish oil tablets (from 2 different manufacturers in case one brand is not up to stuff) during the last couple of weeks as well. This is in addition to regular fish meals (one a day on average) that I have been consuming for years. I also increased my garlic intake from 2 cloves to 4 a day. And, for years, I don't take add any salt to my cooking, and avoid canned soups, salted nuts (but not always), processed foods that have high salt content. Does anyone have any other recommendations? My blood pressure level is about 130/75 despite regular exercise, great diet, and no major weight problem. For the record, my chloresterol level is fantastic, my CRP is good, my homoceistine is under control with vitamin b supplementation, but my bloody blood pressure refuses to go down. The only thing that I cannot control which is a risk factor is my age: I am 54 years young. Any more help out there? Rad -- In , Dowling <christopher.a.dowling@g...> wrote: > Pomegrate, fish oil, garlic, low sodium: > > Clin Nutr. 2004 Jun;23(3):423-33. Related Articles, Links > Click here to read > Pomegranate juice consumption for 3 years by patients with carotid > artery stenosis reduces common carotid intima-media thickness, blood > pressure and LDL oxidation. > > Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld > L, Volkova N, Presser D, Attias J, Liker H, Hayek T. > > The Lipid Research Laboratory, Rappaport Family Institute for > Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, > Israel. aviram@t... > > Dietary supplementation with polyphenolic antioxidants to animals > was shown to be associated with inhibition of LDL oxidation and > macrophage foam cell formation, and attenuation of atherosclerosis > development. We investigated the effects of pomegranate juice (PJ, > which contains potent tannins and anthocyanins) consumption by > atherosclerotic patients with carotid artery stenosis (CAS) on the > progression of carotid lesions and changes in oxidative stress and > blood pressure. Ten patients were supplemented with PJ for 1 year and > five of them continued for up to 3 years. Blood samples were collected > before treatment and during PJ consumption. In the control group that > did not consume PJ, common carotid intima-media thickness (IMT) > increased by 9% during 1 year, whereas, PJ consumption resulted in a > significant IMT reduction, by up to 30%, after 1 year. The patients' > serum paraoxonase 1 (PON 1) activity was increased by 83%, whereas > serum LDL basal oxidative state and LDL susceptibility to copper > ion-induced oxidation were both significantly reduced, by 90% and 59%, > respectively, after 12 months of PJ consumption, compared to values > obtained before PJ consumption. Furthermore, serum levels of > antibodies against oxidized LDL were decreased by 19%, and in parallel > serum total antioxidant status (TAS) was increased by 130% after 1 > year of PJ consumption. Systolic blood pressure was reduced after 1 > year of PJ consumption by 21% and was not further reduced along 3 > years of PJ consumption. For all studied parameters, the maximal > effects were observed after 1 year of PJ consumption. Further > consumption of PJ, for up to 3 years, had no additional beneficial > effects on IMT and serum PON1 activity, whereas serum lipid > peroxidation was further reduced by up to 16% after 3 years of PJ > consumption. The results of the present study thus suggest that PJ > consumption by patients with CAS decreases carotid IMT and systolic > blood pressure and these effects could be related to the potent > antioxidant characteristics of PJ polyphenols. > > PMID: 15158307 [PubMed - indexed for MEDLINE] > > And so on...... > > > On Fri, 07 Jan 2005 22:09:43 -0000, radioreceiver2003 > <radioreceiver2003@y...> wrote: > > > > > > Hi, > > > > Some time back, the polymeal was discussed. > > > > Here is the actual article which was printed in the British Medical > > Journal: http://bmj.bmjjournals.com/cgi/content/full/329/7480/1447 > > > > At the end of the article is an interesting section called rapid > > responses. > > > > Actually, BMJ is an overall good publication to bookmark. > > > > One related question: what does the group suggest in terms of diet > > and nutrition to bring down stubbornly moderately high blood pressure? > > > > Best Regards, > > > > Rad > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2005 Report Share Posted January 7, 2005 Hi Rad: You came to the right place. LOL. A study posted here last year, often referred to as the WUSTL study, analyzed in great detail seventeen subjects who had been on caloric restriction for three or more years. At least one of these subjects is a regular contributor here. These people had had pretty much regular (so called 'normal') test results before going on CRON. The *** AVERAGE *** blood pressure of the members of that group was 100/60. The study also found that the lion's share of the benefits had already appeared after twelve months of CRON. In my opinion it is very likely that if you were to forget everything else and ONLY did CRON as described here and in Walford's 'Beyond the 120-Year Diet', you would no longer have a problem with blood pressure. In the past year, since I initiated CRON, my systolic BP, which wasn't 'high' in the first place, has dropped about one point for each pound of weight lost. I doubt your experience would be any different. In my case, if this continues, when I reach my fully established CRON weight (perhaps at the end of 2005) my BP may also be in the general vicinity of 100/60. Check the archives here to find the WUSTL study. Good luck. Rodney. > > > > > > > > > Hi, > > > > > > Some time back, the polymeal was discussed. > > > > > > Here is the actual article which was printed in the British > Medical > > > Journal: > http://bmj.bmjjournals.com/cgi/content/full/329/7480/1447 > > > > > > At the end of the article is an interesting section called rapid > > > responses. > > > > > > Actually, BMJ is an overall good publication to bookmark. > > > > > > One related question: what does the group suggest in terms of diet > > > and nutrition to bring down stubbornly moderately high blood > pressure? > > > > > > Best Regards, > > > > > > Rad > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2005 Report Share Posted January 8, 2005 Hi: RR... my personal experience is that the most significant reversal in the drift upward of my normal BP with age was linked to my losing weight. I have been pretty active for years but it was only after losing a few tens of pounds did I see not only a reversal in trend but BP fell well below normal. FWIW I am not skinny by CR standards (BMI 21+) but I saw the BP drop precipitously back when I dropped below BMI 24 or so. FWIW I have a friend who is probably lower BMI and for longer than I, who does not have such low BP so there are probably genetic factors too. Perhaps in my case being overweight with periods of obesity for most of my adult life may make my current weight more impactful (High set point? whatever that is). You mention being active. Do you practice any aerobic exercise and if so for sustained periods as this is supposed to help (I was a jogger during my slow BP increases, but pulse was nice and low...). You didn't mention your weight in this post. Losing weight may be productive if you aren't already light. JR -----Original Message----- From: radioreceiver2003 [mailto:radioreceiver2003@...] Sent: Friday, January 07, 2005 4:39 PM Subject: [ ] Re: polymeal Hi Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2005 Report Share Posted January 8, 2005 Hi , Why should you not have lower blood pressure than your less BMI'd friend if your friend is not CRing? Low weight comes with pathologies such as hyperthyroidism in the not CRing. This is my opinion. Cheers, Al. --- In , " " <crjohnr@b...> wrote: > > FWIW I have a friend who is probably lower BMI and for longer than I, who does not have such low BP so there are probably genetic > factors too. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2005 Report Share Posted January 8, 2005 Sorry, I wasn't clear. My friend is more " CR'd " than I am, for a longer time than I (he clued me to Walford and CR), but has higher BP than I do. Inconsistent with a CR trumps all BP mechanisms, think I. JR BTW, I do have lower BP than all my less CR'd friends. :-) -----Original Message----- From: old542000 [mailto:apater@...] Sent: Friday, January 07, 2005 7:58 PM Subject: [ ] Re: polymeal Hi , Why should you not have lower blood pressure than your less BMI'd friend if your friend is not CRing? Low weight comes with pathologies such as hyperthyroidism in the not CRing. This is my opinion. Cheers, Al. --- In , " " <crjohnr@b...> wrote: > > FWIW I have a friend who is probably lower BMI and for longer than I, who does not have such low BP so there are probably genetic > factors too. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2005 Report Share Posted January 8, 2005 Hi Rad: Also apropos your question about persistent highish BP: http://www.heartcenteronline.com/myheartdr/home/research-detail.cfm? reutersid=4912 http://snipurl.com/bvdj Rodney. > > Hi, > > Some time back, the polymeal was discussed. > > Here is the actual article which was printed in the British Medical > Journal: http://bmj.bmjjournals.com/cgi/content/full/329/7480/1447 > > At the end of the article is an interesting section called rapid > responses. > > Actually, BMJ is an overall good publication to bookmark. > > One related question: what does the group suggest in terms of diet > and nutrition to bring down stubbornly moderately high blood pressure? > > Best Regards, > > Rad Quote Link to comment Share on other sites More sharing options...
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