Fish reduced violence, increased prostate cancer

[Guest guest]

Hi All,

Fish fat reduced violence in the first paper below (1), but fish

appeared

to lead to increased prostate cancer in the second (2).

To introduce the first paper, the below URL and Pubmed ID excerpt

appeared to be useful. It explains that corticotrophin releasing

hormone

regulates cortisol, which, according to:

http://tinyurl.com/48jsj

PMID: 12807724

" With increasing dietary

corticosterone, a dose-dependent reduction in the incidence (P=0.03),

multiplicity (P=0.003) and size (P<0.003) of mammary carcinomas was

observed.

.... the lower efficacy of corticosterone versus ER in inhibiting the

carcinogenic process imply that changes in cortical steroid

metabolism alone are

unlikely to explain the cancer inhibitory activity of ER. "

Therefore, it appears that CR benefits correlate with increased

cortisol

levels in CRers.

Further, for corticotrophin releasing hormone, according to:

http://tinyurl.com/6xm7b

PMID: 15460899,

states:

" Eating is thought to be suppressed during stress, due to anorectic

effects of corticotrophin releasing hormone, and increased during

recovery from

stress, due to appetite stimulating effects of residual cortisol. "

Pdfs are available for the below two papers (1, 2).

Looking at the data for the first paper (1), only those in the

lowest tertile

had a greatly enhanced level of corticotrophin-releasing hormone.

1. Hibbeln JR, Bissette G, Umhau JC, DT.

Omega-3 status and cerebrospinal fluid corticotrophin releasing

hormone in

perpetrators of domestic violence.

Biol Psychiatry. 2004 Dec 1;56(11):895-7.

PMID: 15576068 [PubMed - in process]

BACKGROUND: Elevated levels of corticotrophin-releasing hormone in

the

cortical-hippocampal-amygdala pathway increase fear and anxiety,

which are

components of defensive and violent behaviors. Prostaglandins E(2) and

F(2alpha), which increase corticotrophin-releasing hormone RNA

_expression in

this pathway, are reduced by dietary intakes of omega-3 fats.

METHODS: Among 21

perpetrators of domestic violence, cerebrospinal fluid and plasma

were assessed

for corticotrophin-releasing hormone and fatty acid compositions,

respectively.

RESULTS: Lower plasma docosahexaenoic acid (wt% fatty acids) alone

predicted

greater cerebrospinal fluid corticotrophin-releasing hormone (pg/mL),

in

exponential (r = -.67, p < .006) and linear regressions (r = -0.68, p

< .003

excluding four subjects with the highest docosahexaenate levels).

CONCLUSIONS:

In this small observational study, low plasma docosahexaenoic acid

levels were

correlated to higher cerebrospinal fluid corticotrophin-releasing

hormone

levels. ...

Now, (2) is below and appears to state clearly that, fish

consumption correlates

with prostate cancer incidence.

2. Cancer Causes Control. 2004 Nov;15(9):911-20.

A prospective study of diet and prostate cancer in Japanese men.

NE, Sauvaget C, Roddam AW, Appleby P,

Nagano J, Suzuki G, Key TJ, Koyama K.

PMID: 15577293 [PubMed - in process]

... men who consumed fish more than four times per week had a 54

increased

risk of developing prostate cancer compared with men who ate fish

less than

twice per week (RR=1.54; 95 CI, 1.03-2.31). ...

Cheers, Alan Pater