Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi All, We try to get some vitamin D from our exposure to the UV radiation from the sun. What are the risk-benefits of such a strategy. To me, the pdf-available below suggests my cover-up strategy is in order. Again, there is benefits to viewing the pdf above and beyond that for our viewing of the Medline abstract below. A case in point, is the data of Table 1. For: Table 1 .Odds ratios (ORs) of melanoma by demographic, anthropometric,and sun-exposure factors For increasing age in men and women the p for trend = <0.001 and 0.02, respectively. Also, for increasing sunburns at age 11-20, the p for = trend <0.001 and 0.001. This seems to be the age at which exposure, often resulting in sunburn for me and others. The increasing tendency to burn p for trend = <0.001 for both sexes. Decrease in ability to tan values were 0.004 and 0.05. Hair color at age 15 for from Dark brown/black > Light brown > Blond > Red p for trends = <0.001 and <0.001. Increasing freckles at age 20 values were p for trend = <0.001 and <0.001. Cancer Causes Control. 2004 Nov;15(9):893-902. Melanoma and lifetime UV radiation. CC, White E, Kristal AR, Vaughan T. ... this case-control study ... Cases were 386 patients between the ages of 35 and 74 who were diagnosed with primary cutaneous melanoma within the Seattle- Puget Sound area during 1997. Controls were 727 participants of the same age and geographic area, selected by random-digit dialing. A telephone interview ... odds ratios (OR) and 95 confidence intervals (CI) reflecting the risk of melanoma associated with UV exposure, after adjustment for age, sex, income, tendency to burn and sunburns during ages 2-10. Results : Among women, lifetime UV exposure was associated with melanoma risk (adjusted OR=1.99 for highest versus lowest quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were significant trends for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). Among men, there were no significant associations at any time period, but lifetime UV exposure was associated with higher risk for men who had a tendency toward severe or painful sunburns (OR= 2.85 for highest versus lowest quartile, 95 CI: 0.84-9.64, p for trend=0.04). Conclusion : ... it may be useful to target those with a higher sensitivity to the sun when formulating messages for prevention of melanoma by lowering exposure to UV. PMID: 15577291 [PubMed - as supplied by publisher] Cheers, Alan Pater Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 No. Skin cancer in general results from sun exposure, both in youth and later in life. Any tan you get indicates you have undergone chromasomal damage via UV radiation. Melanoma is somewhat different in it's associations with sun exposure than non-melanoma skin cancers, which tend to be associated more with total cumulative sun exposure. On Fri, 10 Dec 2004 07:56:56 -0600, jwwright <jwwright@...> wrote: > > The point, I think has been lost. is that skin cancer develops from sun > exposure in the past, like in youth. Something I have no control over. > And maybe we needed that sunburning at age 10 to ward off PCa? (I have no > idea). > > So what is risk of exposure now at age, to beef up serum vit d? I can't > totally avoid the sun in Texas, as you cannot see the sun for maybe several > months in Canada. But Canadians could use a sun lamp for say 15 mins. > > Regards. > > > > > ----- Original Message ----- > From: old542000 > > Sent: Thursday, December 09, 2004 6:59 PM > Subject: [ ] Melanoma and UV radiation > > > Hi All, > > We try to get some vitamin D from our exposure to the UV radiation > from > the sun. > > What are the risk-benefits of such a strategy. > > To me, the pdf-available below suggests my cover-up strategy is in > order. > > Again, there is benefits to viewing the pdf above and beyond that > for our > viewing of the Medline abstract below. > > A case in point, is the data of Table 1. > > For: > > Table 1 .Odds ratios (ORs) of melanoma by demographic, > anthropometric,and sun-exposure factors > > For increasing age in men and women the p for trend = <0.001 and > 0.02, > respectively. > > Also, for increasing sunburns at age 11-20, the p for = trend > <0.001 and > 0.001. This seems to be the age at which exposure, often resulting in > sunburn for me and others. > > The increasing tendency to burn p for trend = <0.001 for both > sexes. > > Decrease in ability to tan values were 0.004 and 0.05. > > Hair color at age 15 for from Dark brown/black > Light brown > > Blond > > Red p for trends = <0.001 and <0.001. > > Increasing freckles at age 20 values were p for trend = <0.001 and > <0.001. > > Cancer Causes Control. 2004 Nov;15(9):893-902. > Melanoma and lifetime UV radiation. > CC, White E, Kristal AR, Vaughan T. > > ... this case-control study > ... Cases were 386 patients between the ages of 35 and 74 who > were diagnosed with primary cutaneous melanoma within the Seattle- > Puget > Sound > area during 1997. Controls were 727 participants of the same age and > geographic > area, selected by random-digit dialing. A telephone interview ... odds > ratios > (OR) and 95 confidence intervals (CI) reflecting the risk of melanoma > associated > with UV exposure, after adjustment for age, sex, income, tendency to > burn > and > sunburns during ages 2-10. Results : Among women, lifetime UV > exposure was > associated with melanoma risk (adjusted OR=1.99 for highest versus > lowest > quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were significant > trends > for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). > Among men, > there were no significant associations at any time period, but > lifetime UV > exposure was associated with higher risk for men who had a tendency > toward > severe or painful sunburns (OR= 2.85 for highest versus lowest > quartile, 95 > CI: > 0.84-9.64, p for trend=0.04). > Conclusion : ... it may be useful to target those with a higher > sensitivity > to the > sun when formulating messages for prevention of melanoma by > lowering exposure to UV. > PMID: 15577291 [PubMed - as supplied by publisher] > > > Cheers, Alan Pater > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi folks: This is interesting on melanoma, and quite provocative since it suggests that heavy occupational exposure to sunlight REDUCES risk. (Unless I misunderstood?): " Melanoma and sun exposure: an overview of published studies. Elwood JM, Jopson J. Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, New Zealand. melwood@... To assess the association between the incidence of cutaneous melanoma; intermittent, occupational and total sun exposure; and history of sunburn at different ages, we conducted a systematic review using results of all published case-control studies which have assessed incident melanoma, sun exposure and sunburn. Twenty-nine studies contributed data on sun exposure and 21 on sunburn. Overall, there was a significant positive association (odds ratio [OR] = 1.71) for intermittent exposure, a significantly reduced risk for heavy occupational exposure (OR = 0.86) and a small, marginally significant excess risk for total exposure (OR = 1.18). There was a significantly increased risk with sunburn at all ages or in adult life (OR = 1.91) and similarly elevated relative risks for sunburn in adolescence (OR = 1.73) and in childhood (OR = 1.95). There was significant heterogeneity with all of these estimates except that of all ages or adult sunburn. These results show the specificity of the positive association between melanoma risk and intermittent sun exposure, in contrast to a reduced risk with high levels of occupational exposure. The association with sunburn also is likely to reflect intermittent exposure; the results do not suggest any strong relationship to age at sunburn. These associations are similar to those reported for basal cell skin cancer but different from those reported for squamous cell cancer. The mechanisms by which intermittent exposure increases risk, while other patterns of exposure do not, remain to be elucidated. PMID: 9335442 [PubMed - indexed for MEDLINE] " Rodney. > > > > The point, I think has been lost. is that skin cancer develops from sun > > exposure in the past, like in youth. Something I have no control over. > > And maybe we needed that sunburning at age 10 to ward off PCa? (I have no > > idea). > > > > So what is risk of exposure now at age, to beef up serum vit d? I can't > > totally avoid the sun in Texas, as you cannot see the sun for maybe several > > months in Canada. But Canadians could use a sun lamp for say 15 mins. > > > > Regards. > > > > > > > > > > ----- Original Message ----- > > From: old542000 > > > > Sent: Thursday, December 09, 2004 6:59 PM > > Subject: [ ] Melanoma and UV radiation > > > > > > Hi All, > > > > We try to get some vitamin D from our exposure to the UV radiation > > from > > the sun. > > > > What are the risk-benefits of such a strategy. > > > > To me, the pdf-available below suggests my cover-up strategy is in > > order. > > > > Again, there is benefits to viewing the pdf above and beyond that > > for our > > viewing of the Medline abstract below. > > > > A case in point, is the data of Table 1. > > > > For: > > > > Table 1 .Odds ratios (ORs) of melanoma by demographic, > > anthropometric,and sun-exposure factors > > > > For increasing age in men and women the p for trend = <0.001 and > > 0.02, > > respectively. > > > > Also, for increasing sunburns at age 11-20, the p for = trend > > <0.001 and > > 0.001. This seems to be the age at which exposure, often resulting in > > sunburn for me and others. > > > > The increasing tendency to burn p for trend = <0.001 for both > > sexes. > > > > Decrease in ability to tan values were 0.004 and 0.05. > > > > Hair color at age 15 for from Dark brown/black > Light brown > > > Blond > > > Red p for trends = <0.001 and <0.001. > > > > Increasing freckles at age 20 values were p for trend = <0.001 and > > <0.001. > > > > Cancer Causes Control. 2004 Nov;15(9):893-902. > > Melanoma and lifetime UV radiation. > > CC, White E, Kristal AR, Vaughan T. > > > > ... this case-control study > > ... Cases were 386 patients between the ages of 35 and 74 who > > were diagnosed with primary cutaneous melanoma within the Seattle- > > Puget > > Sound > > area during 1997. Controls were 727 participants of the same age and > > geographic > > area, selected by random-digit dialing. A telephone interview ... odds > > ratios > > (OR) and 95 confidence intervals (CI) reflecting the risk of melanoma > > associated > > with UV exposure, after adjustment for age, sex, income, tendency to > > burn > > and > > sunburns during ages 2-10. Results : Among women, lifetime UV > > exposure was > > associated with melanoma risk (adjusted OR=1.99 for highest versus > > lowest > > quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were significant > > trends > > for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). > > Among men, > > there were no significant associations at any time period, but > > lifetime UV > > exposure was associated with higher risk for men who had a tendency > > toward > > severe or painful sunburns (OR= 2.85 for highest versus lowest > > quartile, 95 > > CI: > > 0.84-9.64, p for trend=0.04). > > Conclusion : ... it may be useful to target those with a higher > > sensitivity > > to the > > sun when formulating messages for prevention of melanoma by > > lowering exposure to UV. > > PMID: 15577291 [PubMed - as supplied by publisher] > > > > > > Cheers, Alan Pater > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Apparently the point HAS been lost. The article states: "Among men,> there were no significant associations at any time period, but > lifetime UV> exposure was associated with higher risk for men who had a tendency > toward> severe or painful sunburns" I can't do much about lifetime exposure which will be high for a person who never wore shirts outside in Fla. I can only regulate todays exposure to keep sun related vit D high. How do I do that? And how much exposure required to attain that level? And let's forget the pills. Regards. ----- Original Message ----- From: Dowling Sent: Friday, December 10, 2004 9:20 AM Subject: Re: [ ] Melanoma and UV radiation No. Skin cancer in general results from sun exposure, both in youthand later in life. Any tan you get indicates you have undergonechromasomal damage via UV radiation. Melanoma is somewhat differentin it's associations with sun exposure than non-melanoma skin cancers,which tend to be associated more with total cumulative sun exposure.On Fri, 10 Dec 2004 07:56:56 -0600, jwwright <jwwright@...> wrote:> > The point, I think has been lost. is that skin cancer develops from sun> exposure in the past, like in youth. Something I have no control over. > And maybe we needed that sunburning at age 10 to ward off PCa? (I have no> idea). > > So what is risk of exposure now at age, to beef up serum vit d? I can't> totally avoid the sun in Texas, as you cannot see the sun for maybe several> months in Canada. But Canadians could use a sun lamp for say 15 mins. > > Regards.> > > > > ----- Original Message ----- > From: old542000 > > Sent: Thursday, December 09, 2004 6:59 PM > Subject: [ ] Melanoma and UV radiation > > > Hi All,> > We try to get some vitamin D from our exposure to the UV radiation > from> the sun.> > What are the risk-benefits of such a strategy.> > To me, the pdf-available below suggests my cover-up strategy is in > order.> > Again, there is benefits to viewing the pdf above and beyond that > for our> viewing of the Medline abstract below.> > A case in point, is the data of Table 1.> > For:> > Table 1 .Odds ratios (ORs) of melanoma by demographic,> anthropometric,and sun-exposure factors> > For increasing age in men and women the p for trend = <0.001 and > 0.02,> respectively.> > Also, for increasing sunburns at age 11-20, the p for = trend > <0.001 and> 0.001. This seems to be the age at which exposure, often resulting in> sunburn for me and others.> > The increasing tendency to burn p for trend = <0.001 for both > sexes.> > Decrease in ability to tan values were 0.004 and 0.05.> > Hair color at age 15 for from Dark brown/black > Light brown > > Blond >> Red p for trends = <0.001 and <0.001.> > Increasing freckles at age 20 values were p for trend = <0.001 and> <0.001.> > Cancer Causes Control. 2004 Nov;15(9):893-902.> Melanoma and lifetime UV radiation.> CC, White E, Kristal AR, Vaughan T.> > ... this case-control study> ... Cases were 386 patients between the ages of 35 and 74 who> were diagnosed with primary cutaneous melanoma within the Seattle-> Puget> Sound> area during 1997. Controls were 727 participants of the same age and> geographic> area, selected by random-digit dialing. A telephone interview ... odds> ratios> (OR) and 95 confidence intervals (CI) reflecting the risk of melanoma> associated> with UV exposure, after adjustment for age, sex, income, tendency to > burn> and> sunburns during ages 2-10. Results : Among women, lifetime UV > exposure was> associated with melanoma risk (adjusted OR=1.99 for highest versus > lowest> quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were significant> trends> for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). > Among men,> there were no significant associations at any time period, but > lifetime UV> exposure was associated with higher risk for men who had a tendency > toward> severe or painful sunburns (OR= 2.85 for highest versus lowest > quartile, 95> CI:> 0.84-9.64, p for trend=0.04).> Conclusion : ... it may be useful to target those with a higher > sensitivity> to the> sun when formulating messages for prevention of melanoma by> lowering exposure to UV.> PMID: 15577291 [PubMed - as supplied by publisher]> > > Cheers, Alan Pater> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi folks: Supporting JW's point, I think, is: " Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Hanchette CL, Schwartz GG. Department of Geography, University of North Carolina, Chapel Hill. BACKGROUND. Prostate cancer is the most prevalent nonskin cancer among men in the United States and is the second leading cause of cancer deaths in men. The cause of prostate cancer remains obscure. Recently it was hypothesized that low levels of vitamin D, a hormone with potent antitumor properties, may increase the risk for clinical prostate cancer. METHODS. Because the major source of vitamin D is casual exposure to ultraviolet (UV) radiation, the authors examined the geographic distributions of UV radiation and prostate cancer mortality in 3073 counties of the contiguous United States using linear regression and trend surface analyses. RESULTS. The geographic distributions of UV radiation and prostate cancer mortality are correlated inversely (P < 0.0001). Prostate cancer mortality exhibits a significant north-south trend, with lower rates in the South. These geographic patterns are not readily explicable by other known risk factors for prostate cancer. CONCLUSIONS. These data lend support to the hypothesis that UV radiation may protect against clinical prostate cancer. Viewed in conjunction with other recent data, including those demonstrating a differentiating effect of vitamin D on human prostate cancer cells, these findings suggest that vitamin D may have an important role in the natural history of prostate cancer. PMID: 1451068 [PubMed - indexed for MEDLINE] " Rodney > > No. Skin cancer in general results from sun exposure, both in youth > > and later in life. Any tan you get indicates you have undergone > > chromasomal damage via UV radiation. Melanoma is somewhat different > > in it's associations with sun exposure than non-melanoma skin > cancers, > > which tend to be associated more with total cumulative sun exposure. > > > > > > On Fri, 10 Dec 2004 07:56:56 -0600, jwwright <jwwright@e...> wrote: > > > > > > The point, I think has been lost. is that skin cancer develops > from sun > > > exposure in the past, like in youth. Something I have no control > over. > > > And maybe we needed that sunburning at age 10 to ward off PCa? (I > have no > > > idea). > > > > > > So what is risk of exposure now at age, to beef up serum vit d? I > can't > > > totally avoid the sun in Texas, as you cannot see the sun for > maybe several > > > months in Canada. But Canadians could use a sun lamp for say 15 > mins. > > > > > > Regards. > > > > > > > > > > > > > > > ----- Original Message ----- > > > From: old542000 > > > > > > Sent: Thursday, December 09, 2004 6:59 PM > > > Subject: [ ] Melanoma and UV radiation > > > > > > > > > Hi All, > > > > > > We try to get some vitamin D from our exposure to the UV > radiation > > > from > > > the sun. > > > > > > What are the risk-benefits of such a strategy. > > > > > > To me, the pdf-available below suggests my cover-up strategy > is in > > > order. > > > > > > Again, there is benefits to viewing the pdf above and beyond > that > > > for our > > > viewing of the Medline abstract below. > > > > > > A case in point, is the data of Table 1. > > > > > > For: > > > > > > Table 1 .Odds ratios (ORs) of melanoma by demographic, > > > anthropometric,and sun-exposure factors > > > > > > For increasing age in men and women the p for trend = <0.001 > and > > > 0.02, > > > respectively. > > > > > > Also, for increasing sunburns at age 11-20, the p for = trend > > > <0.001 and > > > 0.001. This seems to be the age at which exposure, often > resulting in > > > sunburn for me and others. > > > > > > The increasing tendency to burn p for trend = <0.001 for both > > > sexes. > > > > > > Decrease in ability to tan values were 0.004 and 0.05. > > > > > > Hair color at age 15 for from Dark brown/black > Light brown > > > > Blond > > > > Red p for trends = <0.001 and <0.001. > > > > > > Increasing freckles at age 20 values were p for trend = <0.001 > and > > > <0.001. > > > > > > Cancer Causes Control. 2004 Nov;15(9):893-902. > > > Melanoma and lifetime UV radiation. > > > CC, White E, Kristal AR, Vaughan T. > > > > > > ... this case-control study > > > ... Cases were 386 patients between the ages of 35 and 74 who > > > were diagnosed with primary cutaneous melanoma within the Seattle- > > > Puget > > > Sound > > > area during 1997. Controls were 727 participants of the same age > and > > > geographic > > > area, selected by random-digit dialing. A telephone interview ... > odds > > > ratios > > > (OR) and 95 confidence intervals (CI) reflecting the risk of > melanoma > > > associated > > > with UV exposure, after adjustment for age, sex, income, tendency > to > > > burn > > > and > > > sunburns during ages 2-10. Results : Among women, lifetime UV > > > exposure was > > > associated with melanoma risk (adjusted OR=1.99 for highest > versus > > > lowest > > > quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were > significant > > > trends > > > for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). > > > Among men, > > > there were no significant associations at any time period, but > > > lifetime UV > > > exposure was associated with higher risk for men who had a > tendency > > > toward > > > severe or painful sunburns (OR= 2.85 for highest versus lowest > > > quartile, 95 > > > CI: > > > 0.84-9.64, p for trend=0.04). > > > Conclusion : ... it may be useful to target those with a higher > > > sensitivity > > > to the > > > sun when formulating messages for prevention of melanoma by > > > lowering exposure to UV. > > > PMID: 15577291 [PubMed - as supplied by publisher] > > > > > > > > > Cheers, Alan Pater > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 I know that the three friends who had melanoma removed were fair skinned, grew up in Fla, Texas. Melanoma kills a lot faster. And Blacks have a higher incidence of PCa, so maybe the skin's ability to react to the sun by tanning is notable for PCa risk. Regards. ----- Original Message ----- From: Rodney Sent: Friday, December 10, 2004 10:40 AM Subject: [ ] Re: Melanoma and UV radiation Hi folks:Supporting JW's point, I think, is:"Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation.Hanchette CL, Schwartz GG.Department of Geography, University of North Carolina, Chapel Hill.BACKGROUND. Prostate cancer is the most prevalent nonskin cancer among men in the United States and is the second leading cause of cancer deaths in men. The cause of prostate cancer remains obscure. Recently it was hypothesized that low levels of vitamin D, a hormone with potent antitumor properties, may increase the risk for clinical prostate cancer. METHODS. Because the major source of vitamin D is casual exposure to ultraviolet (UV) radiation, the authors examined the geographic distributions of UV radiation and prostate cancer mortality in 3073 counties of the contiguous United States using linear regression and trend surface analyses. RESULTS. The geographic distributions of UV radiation and prostate cancer mortality are correlated inversely (P < 0.0001). Prostate cancer mortality exhibits a significant north-south trend, with lower rates in the South. These geographic patterns are not readily explicable by other known risk factors for prostate cancer. CONCLUSIONS. These data lend support to the hypothesis that UV radiation may protect against clinical prostate cancer. Viewed in conjunction with other recent data, including those demonstrating a differentiating effect of vitamin D on human prostate cancer cells, these findings suggest that vitamin D may have an important role in the natural history of prostate cancer.PMID: 1451068 [PubMed - indexed for MEDLINE]"Rodney> And Alan's article said there's a diff in those with sensitive skin.> "Conclusion : ... it may be useful to target those with a higher > > > sensitivity> > > to the> > > sun when formulating messages for prevention of melanoma by> > > lowering exposure to UV."> > Maybe the diff between pops that get PCa versus not. > Regards.> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi folks: Also confusing is that I have read somewhere recently that melanoma usually occurs in places on the body that have rarely been exposed to the sun. In the one case of melanoma of which I am personally aware this was the case. He got it on his TOE! Rodney. > > And Alan's article said there's a diff in those with sensitive skin. > > " Conclusion : ... it may be useful to target those with a higher > > > > sensitivity > > > > to the > > > > sun when formulating messages for prevention of melanoma by > > > > lowering exposure to UV. " > > > > Maybe the diff between pops that get PCa versus not. > > Regards. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi folks: One possible, logical explanation for the apparently reduced risk of heavy occupational sun exposure, but sizeably increased risk for intermittant exposure could be: The person who is continually exposed to sun not only has skin damage but also has the vitamin D (or whatever else it is), continuously and in large quantities, to permit repair of the damage. In contrast those with intermittent exposure cause damage and a short flurry of vitamin D, but then no continuing vitamin D production to continue damage repair. Hence unrepaired damage which eventually leads to cancer? Just an attempt to explain such an odd set of data. Rodney. > > No. Skin cancer in general results from sun exposure, both in youth > > and later in life. Any tan you get indicates you have undergone > > chromasomal damage via UV radiation. Melanoma is somewhat different > > in it's associations with sun exposure than non-melanoma skin > cancers, > > which tend to be associated more with total cumulative sun exposure. > > > > > > On Fri, 10 Dec 2004 07:56:56 -0600, jwwright <jwwright@e...> wrote: > > > > > > The point, I think has been lost. is that skin cancer develops > from sun > > > exposure in the past, like in youth. Something I have no control > over. > > > And maybe we needed that sunburning at age 10 to ward off PCa? (I > have no > > > idea). > > > > > > So what is risk of exposure now at age, to beef up serum vit d? I > can't > > > totally avoid the sun in Texas, as you cannot see the sun for > maybe several > > > months in Canada. But Canadians could use a sun lamp for say 15 > mins. > > > > > > Regards. > > > > > > > > > > > > > > > ----- Original Message ----- > > > From: old542000 > > > > > > Sent: Thursday, December 09, 2004 6:59 PM > > > Subject: [ ] Melanoma and UV radiation > > > > > > > > > Hi All, > > > > > > We try to get some vitamin D from our exposure to the UV > radiation > > > from > > > the sun. > > > > > > What are the risk-benefits of such a strategy. > > > > > > To me, the pdf-available below suggests my cover-up strategy > is in > > > order. > > > > > > Again, there is benefits to viewing the pdf above and beyond > that > > > for our > > > viewing of the Medline abstract below. > > > > > > A case in point, is the data of Table 1. > > > > > > For: > > > > > > Table 1 .Odds ratios (ORs) of melanoma by demographic, > > > anthropometric,and sun-exposure factors > > > > > > For increasing age in men and women the p for trend = <0.001 > and > > > 0.02, > > > respectively. > > > > > > Also, for increasing sunburns at age 11-20, the p for = trend > > > <0.001 and > > > 0.001. This seems to be the age at which exposure, often > resulting in > > > sunburn for me and others. > > > > > > The increasing tendency to burn p for trend = <0.001 for both > > > sexes. > > > > > > Decrease in ability to tan values were 0.004 and 0.05. > > > > > > Hair color at age 15 for from Dark brown/black > Light brown > > > > Blond > > > > Red p for trends = <0.001 and <0.001. > > > > > > Increasing freckles at age 20 values were p for trend = <0.001 > and > > > <0.001. > > > > > > Cancer Causes Control. 2004 Nov;15(9):893-902. > > > Melanoma and lifetime UV radiation. > > > CC, White E, Kristal AR, Vaughan T. > > > > > > ... this case-control study > > > ... Cases were 386 patients between the ages of 35 and 74 who > > > were diagnosed with primary cutaneous melanoma within the Seattle- > > > Puget > > > Sound > > > area during 1997. Controls were 727 participants of the same age > and > > > geographic > > > area, selected by random-digit dialing. A telephone interview ... > odds > > > ratios > > > (OR) and 95 confidence intervals (CI) reflecting the risk of > melanoma > > > associated > > > with UV exposure, after adjustment for age, sex, income, tendency > to > > > burn > > > and > > > sunburns during ages 2-10. Results : Among women, lifetime UV > > > exposure was > > > associated with melanoma risk (adjusted OR=1.99 for highest > versus > > > lowest > > > quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were > significant > > > trends > > > for UV exposure during ages 1-10, 11-20 and 31-40 (all p <0.02). > > > Among men, > > > there were no significant associations at any time period, but > > > lifetime UV > > > exposure was associated with higher risk for men who had a > tendency > > > toward > > > severe or painful sunburns (OR= 2.85 for highest versus lowest > > > quartile, 95 > > > CI: > > > 0.84-9.64, p for trend=0.04). > > > Conclusion : ... it may be useful to target those with a higher > > > sensitivity > > > to the > > > sun when formulating messages for prevention of melanoma by > > > lowering exposure to UV. > > > PMID: 15577291 [PubMed - as supplied by publisher] > > > > > > > > > Cheers, Alan Pater > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi Rodney and All, First, I personally value the source of the publication and nature of its journal. The author affiliations matter not at all. Second, I think it may be hormesis, in which the lower constant level of exposure leads to protection. Give the skin high doses, and sunburns, in the intermittent pattern, and we get cancer. Third, the 7 years more recent paper below seems to say that occupational exposure is a strong risk factor for skin cancer. Br J Dermatol. 2004 Jul;151(1):170-8. Risk and protective factors for sporadic basal cell carcinoma: results of a two-centre case-control study in southern Germany. Clinical actinic elastosis may be a protective factor. Walther U, Kron M, Sander S, Sebastian G, Sander R, RU, Meurer M, Krahn G, Kaskel P. BACKGROUND: There are very few data regarding sun exposure behaviour of patients with basal cell carcinoma (BCC) in central Europe. OBJECTIVES: A case-control study of patients with sporadic BCC was conducted to assess the risk of occupational and leisure-time sun exposure behaviour, precursor lesions for skin cancer and phenotypic factors on the development of sporadic BCC in Ulm and Dresden, Germany. METHODS: A comparison was made of 213 patients with BCC (128 from Ulm, 85 from Dresden; 103 men and 110 women; median age at diagnosis 69 years) and 411 controls (237 from Ulm, 174 from Dresden; 197 men and 214 women; median age 58 years). Crude odds ratios (ORs) and corresponding 95% confidence intervals for all of 64 possible risk factors revealed strong associations in 33 items. Selection of important risk factors was performed in a multiple logistic regression. RESULTS: For sporadic BCC, an increased risk was shown for persons with actinic cheilitis (OR 7.1), actinic keratosis (OR 2.7) and solar lentigo (OR 2.5). The only phenotypic factor indicating risk of sporadic BCC was hair colour, with a higher risk for red/fair than brown/black hair (OR 4.3). There was an increased risk for persons with BCC in first-degree relatives (OR 5.1) and those with sunburn 20 years before sporadic BCC was diagnosed (OR 3.6). Additionally, occupational ultraviolet (UV) exposure appeared to be a risk factor (OR 2.4). In contrast, clinical actinic elastosis showed a protective effect (OR 0.1). CONCLUSIONS: In contrast to earlier reports, clinical actinic elastosis turned out to be the only protective factor for sporadic BCC. A special relationship between wrinkling and BCC risk could not be shown. For basic research, future work should be aimed at elucidating further the different forms of collagen repair processes after intermittent and/or chronic UV exposure. The data strongly support the recommendation that a change in recreational UV exposure habits in individuals, and sunburn avoidance in particular, are necessary not only because of the increased long-term risk of melanoma, but also because of the risk of other skin cancers such as sporadic BCC. PMID: 15270887 [PubMed - indexed for MEDLINE] > > > > > > > > The point, I think has been lost. is that skin cancer develops > > from sun > > > > exposure in the past, like in youth. Something I have no > control > > over. > > > > And maybe we needed that sunburning at age 10 to ward off PCa? > (I > > have no > > > > idea). > > > > > > > > So what is risk of exposure now at age, to beef up serum vit d? > I > > can't > > > > totally avoid the sun in Texas, as you cannot see the sun for > > maybe several > > > > months in Canada. But Canadians could use a sun lamp for say 15 > > mins. > > > > > > > > Regards. > > > > > > > > > > > > > > > > > > > > ----- Original Message ----- > > > > From: old542000 > > > > > > > > Sent: Thursday, December 09, 2004 6:59 PM > > > > Subject: [ ] Melanoma and UV radiation > > > > > > > > > > > > Hi All, > > > > > > > > We try to get some vitamin D from our exposure to the UV > > radiation > > > > from > > > > the sun. > > > > > > > > What are the risk-benefits of such a strategy. > > > > > > > > To me, the pdf-available below suggests my cover-up strategy > > is in > > > > order. > > > > > > > > Again, there is benefits to viewing the pdf above and beyond > > that > > > > for our > > > > viewing of the Medline abstract below. > > > > > > > > A case in point, is the data of Table 1. > > > > > > > > For: > > > > > > > > Table 1 .Odds ratios (ORs) of melanoma by demographic, > > > > anthropometric,and sun-exposure factors > > > > > > > > For increasing age in men and women the p for trend = <0.001 > > and > > > > 0.02, > > > > respectively. > > > > > > > > Also, for increasing sunburns at age 11-20, the p for = > trend > > > > <0.001 and > > > > 0.001. This seems to be the age at which exposure, often > > resulting in > > > > sunburn for me and others. > > > > > > > > The increasing tendency to burn p for trend = <0.001 for > both > > > > sexes. > > > > > > > > Decrease in ability to tan values were 0.004 and 0.05. > > > > > > > > Hair color at age 15 for from Dark brown/black > Light brown > > > > > > Blond > > > > > Red p for trends = <0.001 and <0.001. > > > > > > > > Increasing freckles at age 20 values were p for trend = > <0.001 > > and > > > > <0.001. > > > > > > > > Cancer Causes Control. 2004 Nov;15(9):893-902. > > > > Melanoma and lifetime UV radiation. > > > > CC, White E, Kristal AR, Vaughan T. > > > > > > > > ... this case-control study > > > > ... Cases were 386 patients between the ages of 35 and 74 who > > > > were diagnosed with primary cutaneous melanoma within the > Seattle- > > > > Puget > > > > Sound > > > > area during 1997. Controls were 727 participants of the same > age > > and > > > > geographic > > > > area, selected by random-digit dialing. A telephone > interview ... > > odds > > > > ratios > > > > (OR) and 95 confidence intervals (CI) reflecting the risk of > > melanoma > > > > associated > > > > with UV exposure, after adjustment for age, sex, income, > tendency > > to > > > > burn > > > > and > > > > sunburns during ages 2-10. Results : Among women, lifetime UV > > > > exposure was > > > > associated with melanoma risk (adjusted OR=1.99 for highest > > versus > > > > lowest > > > > quartile, 95 CI: 0.95-3.03, p for trend=0.008). There were > > significant > > > > trends > > > > for UV exposure during ages 1-10, 11-20 and 31-40 (all p > <0.02). > > > > Among men, > > > > there were no significant associations at any time period, but > > > > lifetime UV > > > > exposure was associated with higher risk for men who had a > > tendency > > > > toward > > > > severe or painful sunburns (OR= 2.85 for highest versus lowest > > > > quartile, 95 > > > > CI: > > > > 0.84-9.64, p for trend=0.04). > > > > Conclusion : ... it may be useful to target those with a higher > > > > sensitivity > > > > to the > > > > sun when formulating messages for prevention of melanoma by > > > > lowering exposure to UV. > > > > PMID: 15577291 [PubMed - as supplied by publisher] > > > > > > > > > > > > Cheers, Alan Pater > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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