Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi All, It seems to be that our CR may be safe with respect to our bone health if I interpret the below accurately. Pediatr Res. 2004 Dec 7; [Epub ahead of print] Dietary Restriction Does Not Adversely Affect Bone Geometry and Mechanics in Rapidly Growing Male Wistar Rats. Lambert J, Lamothe JM, Zernicke RF, Auer RN, Reimer RA. ... Two-month-old male Wistar rats were randomized to the ad libitum (n = 8) or the 35% diet-restricted (DR) feeding group (n = 9) for 5 mo. ... L6 vertebrae .... The DR group had significantly lower mean tibial length, mass, area, and cross-sectional moment of inertia, as well as vertebral energy to maximal load. After adjustment for body mass, however, DR tibial mean maximal load and stiffness, and DR vertebral area, height, volume, and maximal load were significantly greater, relative to ad libitum means. No significant differences were found between the DR and ad libitum mineral ash fractions. Because the material properties of the tibiae between the two groups were not significantly different, presumably the material integrity of the bones was not adversely affected as a consequence of DR. The similar material characteristics were consistent with mineral ash fractions that were not different between the two groups. Vertebral maximal load and stiffness were not significant between the DR and ad libitum animals. Importantly, we show that a level of dietary restriction (35%) that is less severe than many studies (40%), and without micronutrient compensation does not adversely affect tibial and vertebral mechanical properties in young growing male rats when normalized for body mass. PMID: 15585686 [PubMed - as supplied by publisher] Cheers, Alan Pater Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hi Al: Particularly interesting I thought was the comment at the end: " Importantly, we show that a level of dietary restriction (35%) that is less severe than many studies (40%), and without micronutrient compensation does not adversely affect tibial and vertebral mechanical properties in young growing male rats when normalized for body mass " . It is the " without micronutrient compensation " that seemed especially encouraging. So if we make sure we get our RDAs we should certainly be OK if those results can be applied to humans. Rodney. --- In , " old542000 " <apater@m...> wrote: > > Hi All, > > It seems to be that our CR may be safe with respect to our bone > health > if I interpret the below accurately. > > Pediatr Res. 2004 Dec 7; [Epub ahead of print] > Dietary Restriction Does Not Adversely Affect Bone Geometry and > Mechanics > in > Rapidly Growing Male Wistar Rats. > Lambert J, Lamothe JM, Zernicke RF, Auer RN, Reimer RA. > > ... Two-month-old male Wistar rats were > randomized to the ad libitum (n = 8) or the > 35% diet-restricted (DR) feeding group (n = 9) for 5 mo. ... L6 > vertebrae > ... The DR group had significantly lower mean tibial length, > mass, area, and cross-sectional moment of inertia, as well as > vertebral > energy > to maximal load. After adjustment for body mass, however, DR tibial > mean > maximal > load and stiffness, and DR vertebral area, height, volume, and > maximal load > were > significantly greater, relative to ad libitum means. No significant > differences > were found between the DR and ad libitum mineral ash fractions. > Because the > material properties of the tibiae between the two groups were not > significantly > different, presumably the material integrity of the bones was not > adversely > affected as a consequence of DR. The similar material characteristics > were > consistent with mineral ash fractions that were not different between > the > two > groups. Vertebral maximal load and stiffness were not significant > between > the DR > and ad libitum animals. Importantly, we show that a level of dietary > restriction > (35%) that is less severe than many studies (40%), and without > micronutrient > compensation does not adversely affect tibial and vertebral mechanical > properties in young growing male rats when normalized for body mass. > PMID: 15585686 [PubMed - as supplied by publisher] > > > Cheers, Alan Pater Quote Link to comment Share on other sites More sharing options...
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