CR and heart disease protection

[Guest guest]

Hi All,

It seems that, in a model of the ischemia heart attack factor,

preconditioning

with ischemia, such as seen in heart attacks, is facilitated by CR.

CR plus exercise appears to be the best remedy for protection.

First, there are two introductory papers, the first of which is

pdf-

available:

Abete P, Cacciatore F, Ferrara N, Calabrese C, de Santis D, Testa

G, Galizia

G, Del Vecchio S, Leosco D, Condorelli M, Napoli C, Rengo F.

Body mass index and preinfarction angina in elderly patients with

acute

myocardial infarction.

Am J Clin Nutr. 2003 Oct;78(4):796-801.

PMID: 14522739 [PubMed - indexed for MEDLINE]

http://tinyurl.com/5pxlu

Long P, Nguyen Q, Thurow C, Broderick TL.

Caloric restriction restores the cardioprotective effect of

preconditioning in

the rat heart.

Mech Ageing Dev. 2002 Jul;123(10):1411-3.

PMID: 12297343 [PubMed - indexed for MEDLINE]

http://tinyurl.com/48pqz

Now, the relevant no pdf-available in press article on a model

of heart attack prevention is below.

Tandem action of exercise training and food restriction

completely preserves ischemic preconditioning in the

aging heart

Experimental Gerontology, In Press,

Corrected Proof, Available online 23 December 2004,

P. Abete, G. Testa, G. Galizia, F. Mazzella, D. Della

Morte, D. de Santis, C. Calabrese, F. Cacciatore, G.

Gargiulo, N. Ferrara et al.

Ischemic preconditioning (IP) has been proposed

as an endogenous form of protection against

ischemia reperfusion injury. IP, however, does

not prevent post-ischemic dysfunction in the aging

heart but may be partially corrected by exercise

training and food restriction. We investigated the

role of exercise training combined with food restriction

on restoring IP in the aging heart. Effects of IP against

ischemia-reperfusion injury in isolated hearts from

adult (A, 6 months old), sedentary `ad libitum' fed (SL),

trained ad libitum fed (TL), sedentary food-restricted

(SR), trained- and food-restricted senescent rats (TR)

(24 months old) ... IP significantly improved final

recovery of percent developed pressure in hearts

from A (p<0.01) but not in those from SL (p=NS) vs

unconditioned controls. Developed pressure recovery

was partial in hearts from TL and SR (64.3 and 67.3%,

respectively; p<0.05 vs controls) but it was total in

those from TR (82.3%, p=NS vs A; p<0.05 vs hearts

from TL and SR). Similarly, IP determined a similar

increase of norepinephrine release in A (p<0.001) and

in TR (p<0.001, p=NS vs adult). IP was abolished by

depletion of myocardial norepinephrine stores by

reserpine in all groups. Thus, IP reduces post-ischemic

dysfunction in A but not in SL. Moreover, IP was

preserved partially in TR and SR and totally in TR.

Complete IP maybe due to full restoration of

norepinephrine release in response to IP stimulus.

Keywords: Aging; Ischemic preconditioning;

Exercise training; Caloric restriction

Cheers, Alan Pater