Role of reactive oxygen species in CR discredited?

[Guest guest]

Hi All,

It seems that more must be understood in the mechanism whereby CR acts,

since

the role of making mitochondrial reactive oxygen species in vivo has been

discredited (3).

Also among the other not pdf-available papers below are two papers (1, 2)

citing

CR and the Medline citations for the latest CR information from Rae (4).

1: Colette C, Ginet C, Boegner C, Benichou M, Pham TC, Cristol JP, Monnier L.

Dichotomous responses of inter and postprandial hyperglycaemia to short-term

calorie restriction in patients with type 2 diabetes.

1: Eur J Clin Invest. 2005 Apr;35(4):259-64.

PMID: 15816995 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15816995

2: Daubressse JC, Cadiere GB, Sternon J.

[Obesity in adult patients: check up and treatment]

Rev Med Brux. 2005 Feb;26(1):33-42. French.

PMID: 15816338 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15816338

3: Lambert AJ, Merry BJ.

Lack of effect of caloric restriction on bioenergetics and reactive oxygen

species production in intact rat hepatocytes.

J Gerontol A Biol Sci Med Sci. 2005 Feb;60(2):175-80.

PMID: 15814858 [PubMed - in process]

To investigate the hypothesis that caloric restriction alters mitochondrial

function in situ, intact hepatocytes were isolated from fully fed and

calorie-restricted (55% of control food intake, 4 months duration) male

Brown-Norway

rats at 6 months of age, and various parameters were determined. Overall, the

production of reactive oxygen species was not affected by caloric restriction,

neither were the mitochondrial membrane potential, oxygen consumption driving

proton

leak, or oxygen consumption driving ATP turnover. It is concluded that while

isolated mitochondria from liver tissue of calorie-restricted animals display a

reduction in the generation of reactive oxygen species, it was not possible to

confirm this effect in isolated hepatocytes. Further work is required to

establish

what effect, if any, caloric restriction has on the rate of generation of

reactive

oxygen species in intact cells and tissues and importantly at the whole-animal

level.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15814858

4: Rae MJ.

All hype, no hope? Excessive pessimism in the " anti-aging medicine " special

sections.

J Gerontol A Biol Sci Med Sci. 2005 Feb;60(2):139-40. No abstract available.

PMID: 15814852 [PubMed - in process]

Al Pater, PhD; email: old542000@...

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