Brain Insulin & Type 3 Diabetes

[Guest guest]

http://news.bbc.co.uk/2/hi/health/4315609.stm

Rodney.

[Guest guest]

Hi All,

Related to the same, see the below that is not pdf-available.

1. Steen E, Terry BM, J E, Cannon JL, Neely TR, Tavares R, Xu

XJ, Wands

JR, de la Monte SM.

Impaired insulin and insulin-like growth factor _expression and

signaling

mechanisms in Alzheimer's disease - is this type 3 diabetes?

J Alzheimers Dis. 2005 Feb;7(1):63-80.

PMID: 15750215 [PubMed - in process]de la Monte SM, Wands JR.

... sporadic Alzheimer's disease (AD) ... The present work

demonstrates extensive abnormalities in insulin and insulin-like

growth factorm typer I and II (IGF-I and IGF-II) signaling mechanisms

in brains with AD, and shows that while each of the corresponding

growth factors is normally made in central nervous system (CNS)

neurons, the _expression levels are markedly reduced in AD. These

abnormalities were associated with reduced levels of insulin receptor

substrate (IRS) mRNA, tau mRNA, IRS-associated phosphotidylinositol 3-

kinase, and phospho-Akt (activated), and increased glycogen synthase

kinase-3beta activity and amyloid precursor protein mRNA _expression.

The strikingly reduced CNS _expression of genes encoding insulin, IGF-

I, and IGF-II, as well as the insulin and IGF-I receptors, suggests

that AD may represent a neuro-endocrine disorder that resembles, yet

is distinct from diabetes mellitus. Therefore, we propose the

term, " Type 3 Diabetes " to reflect this newly identified pathogenic

mechanism of neurodegeneration.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15750215

2. de la Monte SM, Wands JR.

Review of insulin and insulin-like growth factor _expression,

signaling, and

malfunction in the central nervous system: Relevance to Alzheimer's

disease.

J Alzheimers Dis. 2005 Feb;7(1):45-61.

PMID: 15750214 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15750214

Al Pater

--- In , " Rodney " <perspect1111@y...>

wrote:

>

> http://news.bbc.co.uk/2/hi/health/4315609.stm

>

> Rodney.