Guest guest Posted March 21, 2005 Report Share Posted March 21, 2005 Hi folks: The following also seems relevant: " BACKGROUND: The determinants of change in bone mineral density (BMD) have been well characterized in women but not in men. This prospective study describes the patterns of BMD change at the hip and spine, incidence of osteoporosis, and modifiable predictors of bone loss in 507 ambulatory community-dwelling men aged 45 to 92 years. ...................... " RESULTS: Annual BMD loss averaged 0.47% at the total hip and 0.34% at the femoral neck with an annual average of 0.22% gain at the spine. The rate of BMD loss at the hip and incidence of osteoporosis increased significantly with age. The main predictors of BMD loss were age >/=75 years, baseline BMI <24 kg/m(2), 4-year weight loss of >/=5%, current smoking, and physical inactivity. Moderate alcohol consumption showed some bone-sparing effect. Diuretic and calcium supplement use were not associated with bone loss. " CONCLUSIONS: Relatively healthy community-dwelling men lose bone with age, and men aged >/=75 years are particularly vulnerable. Potentially modifiable characteristics such as low body mass, weight loss, smoking, and physical inactivity were important predictors of bone loss and should be considered for the prevention of osteoporosis in men. PMID: 15165661 " Rodney. --- In , " Rodney " <perspect1111@y...> wrote: > > Hi folks: > > I found this to be unusually relevant for males, perhaps not only for > koreans: > > " Osteoporosis is a growing health problem in women and in men. This > cross-sectional study examined the association of anthropometric, > lifestyle, and hormonal factors with bone mineral density (BMD) in > 152 healthy Korean middle-aged men. .................... > > " Of the middle-aged men, 3.9% were osteoporotic and 28.3% were > osteopenic at the lumbar spine site, and 5.9% were osteoporotic and > 45.4% were osteopenic at the femoral neck site. > > " Lumbar spine BMD correlated significantly with body mass index > (BMI), and femoral neck BMD correlated significantly with age, BMI, > and serum IGF-I levels. The lowest quartile group for serum IGF-I > levels showed the lowest femoral neck BMD. > > " Osteoporotic men by lumbar spine BMD showed significant differences > from the normal BMD group in terms of BMI and smoking habits. Also, > osteoporotic men by femoral neck BMD were significantly different for > mean age, BMI, and serum IGF-I levels compared with the normal BMD > group. > > " On multiple regression analysis, BMI was found to be the only > independent predictor of lumbar spine BMD, whereas both BMI and serum > IGF-I levels were found to be the independent predictors of femoral > neck BMD. .................... > > " We suggest that higher age, a lower BMI, current smoking history, > and lower serum IGF-I levels are risk factors for lower BMD in middle- > aged Korean men; however, serum testosterone levels and GH secretory > capacity were not found to be correlated with BMD. > > PMID: 15221500 " > > Note especially the: " BMI was found to be the only independent > predictor of lumbar spine BMD " . > > Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 21, 2005 Report Share Posted March 21, 2005 Hi All, PS from the available pdf: Statistical analysis The SPSS program (version 10.0) for Windows (SPSS, Chicago, IL, USA) was used for statistical analyses. Values for results are given as means±SD. Correlation analyses were performed using the Pearson correlation test. Comparison of mean values between groups, according to the BMD and IGF-I quartiles, were per-formed using analysis of variance (ANOVA) test and post-hoc analysis. For categorical data, the chi^2 test was used for difference of distribution between groups. Multiple regression analyses were used to quantify the predictors of lumbar spine and femoral neck BMD. Variables which showed significance on univariatle analysis were included as independent variables in the regression model, and the final regression model was selected by stepwise selection. Variables with a signifi- cance value of less than 0.05 were included, and vari-ables with a significance value of more than 0.1 were excluded in the final model. Table 4. Comparison of characteristics between nonosteoporotic and osteoporotic subjects ----------------------------------------------- ----Lumbar spine BMD Femoral neck BMD ----Osteoporosis (n=6) Normal (n=103) Osteoporosis (n=9) Normal (n 74) ------------------------------------ Age (years) 57.50±6.95 55.53±6.78 63.00±9.37* 55.00±6.54* BMI (kg/m 2 ) 20.44±2.35** 24.76±2.60** 22.02±2.24** 25.01±2.56** FBS (mg/dl) 84.67±13.20 99.51±32.14 90.78±14.61 98.66±33.51 Alcohol 3/6 (50%) 43/103 (41.7%) 4/9 (44.4%) 31/74 (41.9%) Smoking 5/6 (83.3%)* 30/103 (29.1%)* 4/9 (44.4%) 21/74 (28.4%) Cr (mg/dl) 0.85±0.08 0.95±0.15 0.90±0.10 0.95±0.17 Ca (mg/dl) 8.95±0.29 9.04±0.37 9.12±0.35 9.10±0.33 ALP (U/l) 68.00±17.94 60.10±16.42 60.22±11.07 60.35±18.53 TSH (mIU/l) 1.60±0.86 1.51±0.91 1.43±1.03 1.55±0.943 T (µg/l) 754.00±294.53 597.52±167.89 683.23±288.20 612.19±180.49 IGF-I (µg/l) 233.50±111.70 254.56±78.96 192.89±48.27** 268.39±77.40** GH-peak (µg/l) 17.34±13.03 14.93±11.51 14.56±9.46 13.46±10.87 GH-AUC (µg/l × h) 13.57±10.57 13.01±11.18 12.68±8.87 11.89±11.05 --------------------------------------------- * P <0.05; ** P <0.01 Comparisons were carried out using the t-test and the 2 test BMD, bone mineral density; Ca, serum calcium; ALP, alkaline phosphatase; TSH, thyroid-stimulating hormone; T, testosterone; IGF- I, insulin-like growth factor-I; GH-peak, peak value of growth hormone; GH-AUC, area under the curve of growth hormone Cheers, Al Pater. --- In , " Rodney " <perspect1111@y...> wrote: > > Hi folks: > > I found this to be unusually relevant for males, perhaps not only for > koreans: > > " Osteoporosis is a growing health problem in women and in men. This > cross-sectional study examined the association of anthropometric, > lifestyle, and hormonal factors with bone mineral density (BMD) in > 152 healthy Korean middle-aged men. .................... > > " Of the middle-aged men, 3.9% were osteoporotic and 28.3% were > osteopenic at the lumbar spine site, and 5.9% were osteoporotic and > 45.4% were osteopenic at the femoral neck site. > > " Lumbar spine BMD correlated significantly with body mass index > (BMI), and femoral neck BMD correlated significantly with age, BMI, > and serum IGF-I levels. The lowest quartile group for serum IGF-I > levels showed the lowest femoral neck BMD. > > " Osteoporotic men by lumbar spine BMD showed significant differences > from the normal BMD group in terms of BMI and smoking habits. Also, > osteoporotic men by femoral neck BMD were significantly different for > mean age, BMI, and serum IGF-I levels compared with the normal BMD > group. > > " On multiple regression analysis, BMI was found to be the only > independent predictor of lumbar spine BMD, whereas both BMI and serum > IGF-I levels were found to be the independent predictors of femoral > neck BMD. .................... > > " We suggest that higher age, a lower BMI, current smoking history, > and lower serum IGF-I levels are risk factors for lower BMD in middle- > aged Korean men; however, serum testosterone levels and GH secretory > capacity were not found to be correlated with BMD. > > PMID: 15221500 " > > Note especially the: " BMI was found to be the only independent > predictor of lumbar spine BMD " . > > Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 4, 2006 Report Share Posted August 4, 2006 Hi Ceil! Thanks for sharing your information with us. I'm very curious if there will be any change in you since starting Gleevec. Many Thanks, Lynn > > Hi, > > I am going for a bone density test in a few weeks. I have osteporosis > and have been on Fosamax for about 8or 9 years. My last test showed an > increase in my wrist and I fell 2 yrs ago on my knees without damage, > just bruising. My oncologist knows I am taking Fosamax and has no > problem with it. It will be interesting to see if there are any changes > now that I have CML(dx 6-06) and on Gleevec. Will discuss this with the > rheumatologist, Will update all of you when I get the report. I also > take 600mgs of calcium with vitamin D and will resume my exercise > program at Curves when it cools down. > > Your support is great. > Healthy wishes > Ceil > Quote Link to comment Share on other sites More sharing options...
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