Are Polyunsaturated Fats really good ? - Part Two.

[Guest guest]

Sorry everyone, I added a full stop to the link and that broke it: -

here is link again and below a few of the more recent bits from

pubmed:

http://www.second-opinions.co.uk/fats_and_cancer.html

I don't always mind old studies myself if they are mixed with newer

ones that together give a historical perspective as it helps to show

that the concerns have been there from the start.

The additional studies are from a quick look through pubmed in last

year or so, if I go back further I expect there will be more:

" The results suggest that substituting polyunsaturated FAs with

saturated or monounsaturated FAs may reduce pancreatic cancer risk,

independently of total energy intake, particularly among obese

subjects.British Journal of Cancer advance online publication, 1

February 2005; " PMID: 15685231

Results suggest that long-term dietary corn oil promotes AOM-induced

colon cancer development partly by inhibiting the tumor suppressor

gene p53-mediated mitochondria-dependent apoptosis. (animal study so

don't like this one much, but more studies in this area in pubmed)

PMID: 15522837 [PubMed - indexed for MEDLINE]

RESULTS: After mutual adjustment of different types of fat, an

inverse association with monounsaturated fat and a positive

association with polyunsaturated fat were found. The RR for each 10-

g increment in daily intake of monounsaturated fat was 0.45 (95% CI,

0.22-0.95), whereas the RR for a 5-g increment of polyunsaturated

fat was 1.69 (95% CI, 1.02-2.78); the increments correspond to

approximately 2 SDs of intake in the population. Comparing the

highest quartile of intake with the lowest, we found an RR of 0.8

(95% CI, 0.5-1.2) for monounsaturated fat and 1.2 (95% CI, 0.9-1.6)

for polyunsaturated fat. Saturated fat was not associated with the

risk of breast cancer. CONCLUSIONS: Our results indicate that

various types of fat may have specific opposite effects on the risk

of breast cancer that closely resemble the corresponding effects in

experimental animals. Research investigations and health policy

considerations should take into account the emerging evidence that

monounsaturated fat might be protective for risk of breast cancer.

PMID: 9437377

Use of cod liver oil supplementation and intake of polyunsaturated

fat were associated with significant increased risk and drinking

coffee with significant decreased risk of CMM (cutaneous malignant

melanoma) in women. PMID: 9178814

In models of breast and colon cancer, saturated fats such as beef

fat or lard, and monounsaturated oils, such as olive oil, display

only a weak promoting effect, with the incidence of induced tumors

being similar at intake levels of 40% and 10% of energy. On the

other hand, the n-6-polyunsaturated oils display a strong promoting

effect. Such findings may have a parallel in the low but definitely

increasing slope of postmenopausal breast cancer incidence in the

past 30 years as the American public decreased saturated fat intake

to avoid heart disease and increased use of the n-6-polyunsaturated

oils. PMID: 9216563

It seems that individuals or animals with disordered immune systems

are more reactive to polyunsaturated fatty acid supplementation, and

genetic variation is also a determinant. N-3 polyunsaturated fatty

acids were shown to reduce both resistance to bacterial infection

and host survival. PMID: 15166808

Taken together, linoleic acid, the major PUFA of maize oil, could

have therapeutic efficacy against cellular autoimmune disorders. On

the other hand, excessive intake of linoleic acid may aggravate type

2 autoimmune disorders. PMID: 15115315

However, some studies suggest that high intakes of linoleic acid may

have adverse effects on proinflammatory cytokines and adhesion

molecules. Research is needed to establish the optimal level of

dietary PUFAs that maximally affects the greatest number of health

risk factors. PMID: 15622714

and I have to mention my two favourite studies again:

These findings imply a direct influence of dietary polyunsaturated

fatty acids on aortic plaque formation and suggest that current

trends favouring increased intake of polyunsaturated fatty acids

should be reconsidered. PMID: 7934543

Carbohydrate intake was positively associated with atherosclerotic

progression (P = 0.001), particularly when the glycemic index was

high. Polyunsaturated fat intake was positively associated with

progression when replacing other fats (P = 0.04) but not when

replacing carbohydrate or protein. Monounsaturated and total fat

intakes were not associated with progression. CONCLUSIONS: In

postmenopausal women with relatively low total fat intake, a greater

saturated fat intake is associated with less progression of coronary

atherosclerosis, whereas carbohydrate intake is associated with a

greater progression. PMID: 15531663

richard ........

[Guest guest]

Egads. This guy is affliated with the Weston Price Foundation, a group of

quacks. This kind of citation is worthless here. See past posts about

Weston Price (who is trained as a DENTIST).

I haven't had a chance to look over the Pubmed references.

on 2/20/2005 1:24 PM, rwalkerad1970 at rwalkerad1970@... wrote:

>

>

> Sorry everyone, I added a full stop to the link and that broke it: -

> here is link again and below a few of the more recent bits from

> pubmed:

>

> http://www.second-opinions.co.uk/fats_and_cancer.html

>

> I don't always mind old studies myself if they are mixed with newer

> ones that together give a historical perspective as it helps to show

> that the concerns have been there from the start.

[Guest guest]

Hi :

This is interesting, because if they are referring to ALA (the

abstract just says N-3) then it seems to support, and perhaps suggest

a mechanism for, the studies suggesting ALA promotes prostate cancer.

Rodney.

..........................

> It seems that individuals or animals with disordered immune systems

> are more reactive to polyunsaturated fatty acid supplementation,

and

> genetic variation is also a determinant. N-3 polyunsaturated fatty

> acids were shown to reduce both resistance to bacterial infection

> and host survival. PMID: 15166808

.........................