Guest guest Posted April 19, 2006 Report Share Posted April 19, 2006 Semin Oncol. 2006 Apr;33(2):157-66. Epigenetics in chronic lymphocytic leukemia. Raval A, Byrd JC, Plass C. Department of Molecular Virology, Immunology, and Medical Genetics, Division of Human Cancer Genetics, The Ohio State University, Columbus, OH. Enormous evidence has accumulated in the past decades that establishes the importance of epigenetic modifications* in cancer and has resulted in shifting the focus from entirely genetic-based studies to integrated studies involving both genetic and epigenetic alterations. Chronic lymphocytic leukemia (CLL) is one such example where studies involving epigenetic aberrations have accelerated the search for affected genes, which was initially restricted to commonly deleted chromosomal regions. Many novel genes that are epigenetically silenced in CLL have been identified. Advances in the understanding of post-translational histone modifications and DNA methylation in normal and in CLL cells have proven to be extremely beneficial in finding powerful diagnostic markers, as well as in exploring novel therapies. At present, the field of epigenetics is at an evolving stage, but there is no doubt that further unraveling of its cause and effects in transformed cells will bring a new revolution in cancer therapeutics. PMID: 16616062 [PubMed - in process] *Changes in DNA expression that don't include changes in the base pairs of DNA. An example would be DNA methylation. Quote Link to comment Share on other sites More sharing options...
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