Guest guest Posted March 31, 2005 Report Share Posted March 31, 2005 Hi All, Thank you, Francesca, for the help in posting. Somehow, my previous email address had crept into my address for , and it was bouncing. Almonds do you good. Note the sponsors for the research at the end of the message. The pdf is available. J Am Diet Assoc. 2005 Mar;105(3):449-54. Almonds in the diet simultaneously improve plasma alpha-tocopherol concentrations and reduce plasma lipids. Jambazian PR, Haddad E, Rajaram S, Tanzman J, Sabate J. The objective of this study was to assess the dose-response effect of almond intake on plasma and red blood cell tocopherol concentrations in healthy adults enrolled in a randomized, crossover feeding trial. Participants were 16 healthy men and women, aged 41+/-13 years. After a 2-week run-in period, participants were fed three diets for 4 weeks each: a control diet, a low-almond diet, and a high- almond diet, in which almonds contributed 0%, 10%, and 20% of total energy, respectively. Changes in blood tocopherol levels were assayed by high pressure liquid chromatography. Incorporating almonds into the diet helped meet the revised Recommended Dietary Allowance of 15 mg/day alpha-tocopherol and increased lipid-adjusted plasma and red blood cell alpha-tocopherol concentrations. A significant dose- response effect was observed between percent energy in the diet from almonds and plasma ratio of alpha-tocopherol to total cholesterol. PMID: 15746835 [PubMed - in process] Table 1. Plasma and red blood cell tocopherol and serum lipid levels of subjects following 4 weeks of eating a diet with 0% of energy from almonds, 10% of energy from almonds, and 20% of energy from almonds (N=16)^a ---------------------------------------------------------------------- ---------- Control Low almond High almond P^c -------------------------------------------------------- Plasma tocopherol (microM)^b Chi^2±standard error -------------------------------------------------------- Alpha-tocopherol 26.27±1.07 29.88±1.07u 31.19±1.09u <.01 Gamma-tocopherol 3.06±0.17 1.04±0.18u 1.89±0.18u <.001 ß-tocopherol 0.50±0.04 0.49±0.04u 0.43±0.04uy <.001 Red blood cell tocopherol (microM)b Alpha-tocopherol 3.54±0.24 4.23±0.23w 4.55±0.23u <.001 Gamma-tocopherol 0.51±0.05 0.52±0.05 0.36±0.00ux <.001 ß-tocopherol 0.08±0.01 0.10±0.01 0.07±0.01 .39 Serum lipids Total cholesterol (mmol/L)d 5.50±0.26 5.49±0.26 5.25±0.26vy <.01 Low-density lipoprotein (mmol/L)d 3.81±0.30 3.79±0.30 3.54±0.30uy <.001 High-density lipoprotein (mmol/L)d 1.21±0.06 1.21±0.06 1.23±0.06 .18 Triglycerides (mmol/L)e 1.30±0.22 1.42±0.22 1.29±0.22 .91 Tocopherol:cholesterol (mmol/L:mol/L) Alpha-tocopherol/total cholesterol 48.21±1.94 54.20±1.95u 56.39±1.98u Gamma-tocopherol/total cholesterol 5.72±0.34 4.60±0.35u 3.55±0.35ux ß-tocopherol/total cholesterol 0.91±0.07 0.84±0.07v 0.78±0.07uz ---------------------------------------------------------------------- ----- a^Superscripts indicate significant difference from control diet (u=P<.001, v=P<.01, w=P<.05) and significant difference from low-almond diet (x=P<.001, y=P<.01, z=P<.05). b^To convert microM alpha-, ß-, and gamma-tocopherol to mg/dL, multiply microM by 0.0431, 0.0417, and 0.0417, respectively. c^Analysis of covariance test for trend, using percent of energy from almonds as the covariate. d^To convert mmol/L cholesterol to mg/dL, multiply mmol/L by 38.7. To convert mg/dL cholesterol to mmol/L, multiply mg/dL by 0.026. Cholesterol of 5.00 mmol/L=193 mg/dL. e^To convert mmol/L triglycerides to mg/dL, multiply mmol/L by 88.6. To convert mg/dL triglycerides to mmol/L, multiply mg/dL by 0.0113. Triglycerides of 1.80 mmol/L=159 mg/dL. ... Conclusions • The recommended dietary allowance for vitamin E has been increased to 15 mg/day a-tocopherol for both men and women. The typical US diet is low in a- tocopherol. One ounce of almonds (165 kcal) can be isocalorically substituted for white bread, crackers, chips, and similar refined products to provide 7.4 mg a- tocopherol. • Other than almonds, foods that provide >4 mg a-tocopherol in a typical serving are sunflower seeds, hazelnuts, wheat germ, wheat germ oil, sunflower oil, cottonseed oil, and safflower oil (6). Other important sources are green vegetables, tomato sauce, avocado, mango, and papaya. Dietetics professionals and nutrition educators can encourage the public to consume foods as opposed to dietary supplements that in addition to a-tocopherol contain important nutrients and bioactive substances (40). • Incorporating almonds into a diet may not be feasible for some persons due to personal preference, allergies, or economic factors. A limiting factor of our study is that only one food could be tested at a time to determine its ability to increase plasma vitamin E concentrations. The results suggest that consuming foods that are good sources of vitamin E may help to meet current recommendations. Public health messages can stress culturally acceptable foods that are good sources of vitamin E. Dietetics professionals can develop eating plans for groups or persons utilizing these foods. Acknowledgements This study was partially supported by a research grant from the Almond Board of California, Modesto, CA. 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