Randomized test of Plerixafor+g-csf for Mobilization of Hematopoietic Stem Cell

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12 Months Report from the Phase 3 Study of Plerixafor+G-CSF VS. Placebo+G-CSF

for Mobilization of Stem Cell for Autologous Transplant in Patients with NHL

http://ash.confex.com/ash/2008/webprogram/Paper3053.html

n = 89/150 (59%) patients in the plerixafor group and 29/148 (20%) patients in

the placebo group

Conclusions: The addition of plerixafor to G-CSF resulted in higher CD34+ cell

collection in fewer days of apheresis and higher proportion of patients

proceeding to transplant than G-CSF alone. Importantly, this 12 months report

showed that transplants with cells collected with plerixafor resulted in graft

durability rates that were similar to cells collected with G-CSF alone.