NEJM report: role of public-sector research

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SPECIAL ARTICLE

The Role of Public-Sector Research in the Discovery of Drugs and Vaccines

J. s, D.Phil., J. Jensen, M.B.A., Katrine Wyller,

M.B.E., C. Kilgore, B.S., Sabarni Chatterjee, M.B.A., Ph.D., and

Mark L. Rohrbaugh, Ph.D., J.D.

N Engl J Med 2011; 364:535-541February 10, 2011

http://www.nejm.org/doi/full/10.1056/NEJMsa1008268#t=article full text

.. Our research has so far identified 153 FDA-approved drugs that were

discovered at least in part by PSRIs during the past 40 years (Table 1

http://www.nejm.org/doi/full/10.1056/NEJMsa1008268#t=article

.... Because our sources were not limited to products for which a

public-sector patent was listed in the Orange Book, we identified 102 new

molecular entities (including 8 in vivo diagnostic materials and 1

over-the-counter product) for which a total of 161 new-drug applications

were approved. We also identified 36 biologic drugs and 15 vaccines that

received approval under biologics license applications, for a total of 153

drugs that received 206 new-drug or biologics license applications.