HDAC inhibitors trials: CLL / Lymphoma

[Guest guest]

Greetings,

Here's a query showing trials recruiting for lymphoma OR CLL that includes

HDAC inhibitors in the protocols http://bit.ly/eGDBGq

Notes on trials:

Most community oncologists do not refer to trials, and for a variety of

reasons: http://www.lymphomation.org/docsurvey-chart2.PDF

As always, seek independent expert guidance to help you to identify studies

that may be appropriate for your clinical circumstance and treatment goals.

The best time to consider trials can be when a response to therapy is not

essential, or when the standard of care for your clinical circumstance or

diagnosis has significant limitations)

See 7 Reasons to Consider Clinical Trials:

based on your clinical circumstances

Meeting the dual requirements: Good Science AND Good Medicine

http://bit.ly/9OSXSB

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This cartoon shows how HDAC inhibitors may work:

http://www.ncbi.nlm.nih.gov/books/NBK13838/figure/A612/?report=objectonly

( " DNA that is tightly wrapped around a deacetylated histone core relaxes "

allowing " silenced " genes to function normally)

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Finally, a paper describing what is known and unknown about the mechanisms

of action for HDAC inhibitors. And clinical results so far.

Targeting histone deacetyalses in the treatment of B- and T-cell

malignancies

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003796/

(Technical, but more readable than many papers on the subject.)

Snip: " HDAC inhibitors (HDACI) are now emerging as one of the most

promising new classes of drugs for the treatment of select forms of

non-Hodgkin's lymphoma (NHL). They are particularly active in T-cell

lymphomas, possibly hodgkin's lymphoma and indolent B cell lymphomas.

Presently, two of these agents, vorinostat and romidepsin, have been

approved in the US for the treatment of relapsed and refractory cutaneous T

cell lymphomas (CTCL). Initially, these agents were developed with the idea

that they affected transcriptional activation and thus gene expression, by

modulating chromatin condensation and decondensation. "

All the best,

~ Karl

Patients Against Lymphoma

Patients Helping Patients

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www.lymphomation.org | Current News: http://bit.ly/f2A0T

How to Help: www.lymphomation.org/how-to-help.htm