Insights into the Biology of CLL

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Novel Insights into the Biology of CLL

http://bit.ly/eJHpEM

" Several characteristics of CLL facilitate basic and translational research:

(i) the high population prevalence; (ii) the malignant cells are easily

obtained through venous phlebotomy; (iii) most patients have an asymptomatic

phase that allows for longitudinal evaluation; and (iv) CLL is has a

relatively long disease-specific survival. Therefore, CLL has become a model

system for the investigation of B-cell lymphoproliferative disorders.

In the 5 years since the biology of CLL was last broadly reviewed in the

American Society of Hematology education session, tremendous progress has

been made in the understanding of CLL disease biology, and this review will

focus on these discoveries. Specifically, important advances have been made

in identifying inherited and acquired genetic mutations, the role of B-cell

receptor (BCR) signaling, and the interplay between the malignant B cells

and the tumor microenvironment. These advances reveal CLL to be a disease

that is dependent on on the interplay of inherited, environmental, and host

factors. "

All the best,

~ Karl

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