Cutaneous reactive angiomatosis associated with chronic lymphoid leukemia.

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Cutaneous reactive angiomatosis associated with chronic lymphoid leukemia.

EA Marinas, N Vidaurrazaga, JJ Burgos-Bretones, X Eizagirre, ZM de Lagran, R

Izu, and JL -

Am J Dermatopathol, December 1, 2008; 30(6): 604-7.

From the Department of Dermatology, Hospital de Cruces, Plaza de Cruces s/n,

48903 Baracaldo. (Vizcaya), Spain.

Cutaneous reactive angiomatosis is an unusual benign vascular disorder of the

skin usually associated to systemic diseases. It is characterized by lobular or

diffuse proliferation of small blood vessels with hyperplasia of endothelial

cells, pericytes, and sometimes histiocytes. We report a 59-year-old man with

asymptomatic erythematous-violaceous patches on back, palms, and elbows for 9

months. Laboratory examination revealed changes consistent with B-chronic

lymphocytic leukemia. Cutaneous biopsy showed a predominantly lobular small

blood vessel proliferation in dermis with pericytic hyperplasia and mild

perivascular lymphoplasmacytic infiltrate. Spontaneous involution of lesions

occurred after 6 months. A second biopsy performed at the beginning of clinical

involution showed a less prominent vascular component with perivascular giant

cells with coexpression of CD68 and CD 31. To our knowledge, this is the first

case of cutaneous reactive angiomatosis with documented histopathological

findings of clinical involution.

PMID: 19033939