Chronic Lymphoid Leukemias Other Than Chronic Lymphocytic Leukemia: Diagnosis and Treatment

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BlankMayo Clin Proc. 2005;80:1660-1674 © 2005 Mayo Foundation for Medical

Education and Research

Chronic Lymphoid Leukemias Other Than Chronic Lymphocytic Leukemia: Diagnosis

and Treatment

FARHAD RAVANDI, MD; SUSAN O’BRIEN, MD

Address correspondence to Farhad Ravandi, MD, Department of Leukemia, Box 428,

The University of Texas M. D. Cancer Center, 1515 Holcombe Blvd,

Houston, TX 77030 (e-mail: fravandi@...). Individual reprints of this

article and a bound booklet of the entire Symposium on Oncology Practice:

Hematological Malignancies will be available for purchase from our Web site

www.mayoclinicproceedings.com.

The World Health Organization classification divides lymphoid malignancies into

precursor B-cell and T-cell neoplasms as well as mature B-cell and T-cell

neoplasms. Mature B-cell neoplasms comprise more than 85% of non-Hodgkin

lymphomas worldwide and can be further subclassified according to the postulated

cell of origin by using specific morphologic, immunophenotypic, and molecular

characteristics. Similarly, the more uncommon mature T-cell neoplasms have been

better characterized to include numerous distinct entities with widely varying

natural histories. The distinction between lymphoma and leukemia is somewhat

arbitrary and is based on variable involvement of the bone marrow, peripheral

blood, and lymphatic system. In this article, we review the diagnostic and

clinical features of mature B-cell and T-cell lymphoproliferative disorders that

commonly have a leukemic presentation.

Mayo Clin Proc. 2005;80(12):1660-1674