Re: Fructose, glycation, and lifespan

[Guest guest]

Here is a paper that says that glycation is dependent on caloric

intake, rather than the consumption of fructose or other

carbohydrates. Apparently, caloric restriction reduces the levels of

sugars that cause age-related accumulation of glycation products.

Tony

http://www.nutrition.org/cgi/content/full/130/5/1247

(Journal of Nutrition. 2000;130:1247-1255.)

Accumulation of Advanced Glycation Endproducts in Aging Male Fischer

344 Rats during Long-Term Feeding of Various Dietary Carbohydrates.

" This study was designed to evaluate the long-term effects of dietary

carbohydrates on serum and tissue markers of glycemic stress.

Three-month-old male Fischer 344 rats were given free access to or

restricted to 60% caloric intake of one of five isocaloric diets that

contained as their carbohydrate source either cornstarch, glucose,

sucrose, fructose or equimolar amounts of fructose and glucose. Rats

were killed at 9-, 18- or 26-mo of age. Glycated hemoglobin, serum

glucose and fructosamine levels were measured as markers of serum

glycemic stress. Collagen-associated fluorescence and pentosidine

concentrations were measured in skin, aortic, tracheal and tail tendon

collagen as markers of advanced glycation endproducts (AGE). The

source of dietary carbohydrate had little effect on markers of

glycemic stress and the accumulation of AGE. Restricting the amount of

calories consumed resulted in lower serum glucose concentrations,

glycated hemoglobin levels and pentosidine concentrations in tail

tendon collagen. Our data suggest that the rate of collagen glycation

is tissue-specific. These results suggest that long-term feeding of

specific dietary carbohydrates does not alter serum glucose

concentrations or the rate of collagen glycation. Rather, age-related

accumulation of AGE is more closely related to caloric intake. "

>>>

From: Logan <loganruns73@y...>

Date: Thu Feb 10, 2005 12:15 am

Subject: Re: Fructose reduced lifespan of mice by 95%

There is evidence that fructose accelerates the

formation of advanced glycation endbyproducts, one of

the several theories of aging. Example:

http://www.nutrition.org/cgi/content/abstract/128/9/1442

Logan

>>>

[Guest guest]

Hi:

Only perhaps peripherally related to Tony's post ..... I started

very gradual CRON about a year ago. In the past year I have learned

a great deal more about it than I knew before, almost all from what

has been posted here.

The more I learn the more I notice a mild but growing sense of alarm

at the fact that I had not started CR a lot sooner. Better late than

never, of course. And in my case fortunate that I never was on

a 'caloric distension' diet; and had 'ON' perhaps about 70% right

before starting CR. But I really feel sorry for the people who will

never get to learn, and implement, the kind of information that we

all have access to here - such as the study Tony posted below.

Rodney.

>

> Here is a paper that says that glycation is dependent on caloric

> intake, rather than the consumption of fructose or other

> carbohydrates. Apparently, caloric restriction reduces the levels

of

> sugars that cause age-related accumulation of glycation products.

>

> Tony