[The clinical and laboratory features of 263 cases of chronic lymphocytic leukemia]

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[The clinical and laboratory features of 263 cases of chronic lymphocytic

leukemia]

ZJ Li, LG Qiu, T Wu, YF Wang, DH Zou, YZ Zhao, JY Qi, RC Yang, and LS Qian

Zhonghua Xue Ye Xue Za Zhi, May 1, 2008; 29(5): 300-3.

Institute of Hematology and Blood Diseases Hospital, CAMS, Tianjin 300020,

China.

OBJECTIVE: To analyze the clinical and laboratory features of chronic

lymphocytic leukemia (CLL). METHODS: Retrospective investigation of 263 patients

with CLL in our hospital between Feb. 2000 and Jan. 2007. RESULTS: The median

age was 60 years with male/female ratio of 2.17 : 1. Patients who were

asymptomatic at diagnosis (35.4%) had low Rai grades. Fatigue and

lymphadenopathy (54.8%) were the most common features at presentation.

Infections, connective tissue diseases and secondary tumors frequently occured

in CLL. WBC counts were between (10 - 100) x 10(9)/L, with lymphocytes

percentages more than 0.50 in 97.1% patients. Bone marrow was normal- to

hyper-cellularity with lymphocytes percentages more than 0.300 in 99.4%

patients. Diffuse infiltrations in bone marrow section were found in 72.2%

patients. There were lower CD5 (85.1%) and higher CD25 (78.9%) positivities in

the present series as compared with that in other reports.

Hypogammaglobulinemia, especially hypo-IgM, usually occured. Chromosome

abnormality were rarely found by routine chromosome examination. CONCLUSIONS:

There were some clinical and laboratory characteristics different from that of

abroad data. Further exploration of new markers is required for prognosis

prediction and treatment choice.

PMID: 18844065