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Mechanism Responsible for Autoimmunity Discovered?

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Researchers Identify Novel Pathophysiologic Mechanism Responsible for

Autoimmunity

ScienceDaily (Apr. 25, 2011) - Researchers from Boston University School of

Medicine (BUSM) have discovered that human proteins with an affinity for

dermatan sulfate (DS) have the propensity to become autoantigens.

In a companion article, the researchers also found that DS physically

interacts with dead cells and that the resulting DS-autoantigen complexes

drive autoreactive B-1a cell responses and autoantibody production both

in-vitro and in mouse models.

http://www.sciencedaily.com/releases/2011/04/110425120349.htm

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