Trisomy 8 in B-cell chronic lymphocytic leukemia.

[Guest guest]

Trisomy 8 in B-cell chronic lymphocytic leukemia.

O Pozdnyakova, D Stachurski, L Hutchinson, S Ramakrishnan, and PM Miron

Cancer Genet Cytogenet, May 1, 2008; 183(1): 49-52.

Department of Pathology, UMASS Memorial Medical Center, Biotech Three, One

Innovation Drive, Worcester, MA 01605, USA.

Association between trisomy 8 and myeloid disorders/malignancies has been well

documented. We report on two patients with a known history of B-cell chronic

lymphocytic leukemia (B-CLL) with bone marrow involvement. In addition to the

classic B-CLL cytogenetic abnormalities in one of the patients, both showed a

trisomy 8 clone in their bone marrow specimens. Using a BioView Duet automated

scanning system, which allowed us to combine histology with fluorescence in situ

hybridization, we showed that the trisomy 8 clone was restricted to the myeloid

lineage. We believe that this finding signifies the development of

myelodysplastic syndrome (de novo or therapy related), rather than progression

of B-CLL with the occurrence of a new clone, and that in general, it has

implications for the finding of trisomy 8 in CLL.

PMID: 18474297