Acute renal failure secondary to chronic lymphocytic leukemia: a case report

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Acute renal failure secondary to chronic lymphocytic leukemia: a case report.

SI Rifkin

Medscape J Med, January 1, 2008; 10(3): 67.

Division of Nephrology, University of South Florida College of Medicine, Tampa,

Florida, USA. srifkin@...

Acute renal insufficiency associated with chronic lymphocytic leukemia (CLL) has

a variety of causes. An extremely rare cause of renal dysfunction is dense

leukemic infiltrate in the renal interstitium. This report describes a patient

with CLL who developed acute renal failure secondary to leukemic infiltration

and who had a partial response to chemotherapy. This diagnosis should always be

considered when a patient with CLL, regardless of the clinical stage, presents

with renal insufficiency because it appears to respond reasonably well to a

variety of therapies. The finding of enlarged kidneys on renal ultrasound is

suggestive of infiltrative disease, but is not always present. Proteinuria is

generally mild. The literature is reviewed.

PMID: 18449351