Re: Re: linoleic acid vs sat fat -- other equations?

[Guest guest]

No argument. Here are more equations, I got from wuzzy@....

Sorry I don't have the refs. and there were some signs lost in email.

I'll try to find them but juts throwing the idea up that there are others doing this sort of thing.

Regards.

Total cholesterol in mg/dLHegsted et al (85)del TC = 2.16 del S 1.65 del P + 0.067 del C 0.53

Keys et al (97)del TC = 1.35(2 del S del P) + 1.52 del Z

Total, LDL, and HDL cholesterol in mg/dL

Mensink and Katan (104)del TC = 1.51 del S 0.12 del M 0.60 del Pdel LDLC = 1.28 del S 0.24 del M 0.55 del Pdel HDLC = 0.47 del S + 0.34 del M + 0.28 del P

Hegsted et al (158)del TC = 2.10 del S 1.16 del P + 0.067 del Cdel LDLC = 1.74 del S 0.77 del P + 0.044 del C

Yu et al (157)del TC = 2.02 del 12:0-16:0 0.03 del 18:0 0.48 del M 0.96 del Pdel LDL-C = 1.46 del 12:0-16:0 + 0.07 del 18:0 0.69 del M 0.96 del Pdel HDL-C = 0.62 del 12:0-16:0 0.06 del 18:0 + 0.39 del M + 0.24 del P

LDL cholesterol expressed in terms of percentage change2del LDL-C (%) = 1.34 del S 0.59 del P + 0.033 del C1 Where del TC, del LDL-C, and del HDL-C are changes in plasma total,LDL, and HDL cholesterol; del S is change in percentage of daily energyfrom saturated fatty acids; del M is change in percentage of daily energyfrom monounsaturated fatty acids; del P is change in percentage of daily energyfrom polyunsaturated fatty acids; del Z is change in the square root of dailydietary cholesterol in 60 ng/kJ (mg/1000 kcal); and del C is change indietary cholesterol in mg/d.2 Based on Hegsted et al (158), converted to percentage change assumingan average LDL-C concentration of 3.4 mmol/L (130 mg/dL).

----- Original Message -----

From: old542000

Sent: Sunday, February 06, 2005 3:05 PM

Subject: [ ] Re: linoleic acid vs sat fat -- how about fish oil?

Hi All,The point that I did not make clear is that the equation says so-and-so improves risk of morbitiy and mortality due to theoretical considerations. This is the beautiful hypothesis. The predictions seem to be not related to less disease and longer life. This is the ugly fact.And, both are my opinions.Beauty is in the eye of the beholder. Ugly is where I look.Cheers, Al.> > The quantitative relationships expressed by the Hegsted equation are> not derived from a 'hypothesis', they are the result of mathematical> analysis of many **measurements** of the effect of specific fatty> acids on blood lipid metabolism. The equation has general> applicability because it was developed from data for many individuals.> Since there is variability in the effect of fats on specific> individuals, the resulting equation can only make predictions with a> specific margin of confidence, but it is reliable enough that it is> widely used for dietary analysis.> > Quantitative relationships that are developed from measurements, such> as Isaac Newton's gravitational equations are able to withstand the> test of centuries. Apples will continue to fall from the trees with> an acceleration of 9.8 meters/second squared, regardless of any> hypotheses to the contrary. ... and myristic acid will still be over> eight times more cholesteremic than stearic acid even for Huxley's> descendants.> > Tony> > =====> Am J Clin Nutr. 1965 Nov;17(5):281-95. > Quantitative effects of dietary fat on serum cholesterol in man.> Hegsted DM, McGandy RB, Myers ML, Stare FJ.> PMID: 5846902> > >>>> From: "old542000" <apater@m...>> Date: Sat Feb 5, 2005 9:11 pm> Subject: Re: linoleic acid vs sat fat -- how about fish oil?> > Hi All,> > Henry Huxley, the 19th-century British scientist, said that> science has many examples of beautiful hypotheses slain by ugly facts.> > Using the Hegsted equation, rests on the hypothesis that it is> correct, correct?> > Cheers, Al Pater> >>>