Serum thrombopoietin compared with ZAP-70 and immunoglobulin heavy-chain gene mutation status as a predictor of time to first treatment in early chronic lymphocytic leukemia

January 28, 2008

Serum thrombopoietin compared with ZAP-70 and immunoglobulin heavy-chain gene

mutation status as a predictor of time to first treatment in early chronic

lymphocytic leukemia.

S Molica, G Vitelli, G Cutrona, K Todoerti, R Mirabelli, G Digiesi, F Morabito,

A Neri, and M Ferrarini

Leuk Lymphoma, January 1, 2008; 49(1): 62-7.

In an effort to confirm previous reports we analyzed clinico-biological

implications of increased serum levels of thrombopoietin (TPO) in a series of 71

previously untreated Binet stage A B-cell chronic lymphocytic leukemia (CLL)

patients. Serum levels of TPO did not correlate with peripheral blood

lymphocytosis (p = 0.928), Rai substages (p = 0.516), platelet count (p =

0.572), hemoglobin level (p = 0.228), LDH (p = 0.144) and beta(2)-microglobulin

(p = 0.520). The same applied when correlation with ZAP-70 (p = 0.562), CD38 (p

= 0.258) or mutational status of IgV(H) (p = 0.0794) were sought. The risk of

disease-progression according to known and putative prognostic parameters was

also evaluated as time to first treatment (TFT). The univariate proportional

hazard model demonstrated that the absence of IgV(H) mutational status (p =

0.0005) and ZAP-70-positivity (p = 0.02) were associated with a shorter TFT. In

contrast, Kaplan-Meier estimates of TFT, plotted after setting as cut-off the

median value for TPO (i.e., 46 pg/mL), failed to demonstrate any statistical

difference between two groups (p = 0.342). Looking for cellular source of TPO we

investigated the presence of TPO at gene expression level in 60 B-CLL patients

belonging to an independent series. Here we provide evidence for the presence of

a low TPO gene expression transcript in B-CLL cells. In conclusion, our results

indicate that in early B-cell CLL circulating level of TPO does not provide a

useful insight into the complex interrelationship of prognostic variables.

PMID: 18203013

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