Health Professionals Follow-Up Study wrt Fructose

February 9, 2005

Hi folks:

" Non-fruit sources of fructose similarly predicted lower risk of

advanced prostate cancer. "

--------------------------------

" Calcium and fructose intake in relation to risk of prostate cancer.

Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA,

Willett WC.

Department of Medicine, Harvard Medical School and Brigham and

Women's Hospital, Boston, Massachusetts 02115, USA.

Laboratory and clinical data indicate an antitumor effect of 1,25(OH)

2 vitamin D (1,25(OH)2D) on prostate cancer. High calcium intake

suppresses formation of 1,25(OH)2D from 25(OH)D, thereby decreasing

the 1,25(OH)2D level. Ingestion of fructose reduces plasma phosphate

transiently, and hypophosphatemia stimulates 1,25(OH)2D production.

We thus conducted a prospective study among 47,781 men of the Health

Professionals Follow-Up Study free of cancer in 1986 to examine

whether calcium and fructose intake influenced risk of prostate

cancer. Between 1986 and 1994, 1369 non-stage A1 and 423 advanced

(extraprostatic) cases of prostate cancer were diagnosed. Higher

consumption of calcium was related to advanced prostate cancer

[multivariate relative risk (RR), 2.97; 95% confidence interval (CI),

1.61-5.50 for intakes > or = 2000 mg/day versus < 500 mg/day; P,

trend, 0.002] and metastatic prostate cancer (RR, 4.57; CI, 1.88-

11.1; P, trend, <0.001). Calcium from food sources and from

supplements independently increased risk. High fructose intake was

related to a lower risk of advanced prostate cancer (multivariate RR,

0.51; CI, 0.33-0.80, for intakes > 70 versus < or = 40 g/day; P,

trend, 0.007). Fruit intake was inversely associated with risk of

advanced prostate cancer (RR, 0.63; 95% CI, 0.43-0.93; for > 5 versus

< or = 1 serving per day), and this association was accounted for by

fructose intake. Non-fruit sources of fructose similarly predicted

lower risk of advanced prostate cancer. A moderate positive

association between energy-adjusted fat intake and advanced prostate

cancer was attenuated and no longer statistically significant when

controlled for calcium and fructose. Our findings provide indirect

evidence for a protective influence of high 1,25(OH)2D levels on

prostate cancer and support increased fruit consumption and avoidance

of high calcium intake to reduce the risk of advanced prostate cancer.

PMID: 9458087 [PubMed - indexed for MEDLINE] "

Rodney.

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