Guest guest Posted May 19, 2005 Report Share Posted May 19, 2005 , V; Heilbronn, Leonie K; Ravussin, Energy restriction and aging. Current Opinion in Clinical Nutrition & Metabolic Care. 7(6):615-622, November 2004. Conclusion Prolonged energy restriction has been proven to extend the lifespan of various lower species. Although it remains unknown if such an extension will apply to the longevity of longer-lived species such as humans, the benefits of prolonged calorie restriction appear to be numerous. Many of the physiological changes observed with prolonged calorie restriction are conducive to improved health and quality of life, and may possibly delay the onset of age-related diseases and morbidities in humans. The benefits shown by studies of prolonged energy restriction are diverse and include ‘healthier’ body composition, decreases in energy expenditure and oxidative damage, improvements in insulin sensitivity with concomitant decreased risk of type 2 diabetes, and improvement of lipid profile and endothelial function with decreased risk of cardiovascular disease. Due to the pluripotent nature of energy restriction, the exact mechanisms by which calorie restriction extend lifespan are still being investigated, and will likely remain a challenge. However, controlled human trials of prolonged energy restriction, such as the multi-center CALERIE study, are transforming this challenging investigation into a modern scientific reality. ----- Original Message ----- From: Sent: Thursday, May 19, 2005 12:36 PM Subject: [ ] New file uploaded to Quote Link to comment Share on other sites More sharing options...
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