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Hi All,

For diet advice from Nature that is not

in Medline yet, see the below.

DECLAN BUTLER AND HELEN PEARSON

Nature 433, 794 - 796 (24 February 2005)

Dietary advice: Flash in the pan?

Obesity is the main target in the US government's latest dietary

guidelines. But can this advice really make a difference? Nature's

reporters sift through the heady mix of politics and science to get a

taste of things to come.

" If you follow this diet, you're going to lose weight, you're

going to be healthy and you're going to be able to improve your

quality of life ... it's scientifically based, but it's also common

sense. "

Another diet guru flogging their snake-oil prescription for the

servings of fat, carbohydrate, protein and other nutrients needed to

be healthy and slim? No. This was Tommy , then US Secretary

of Health, speaking on 12 January at the release of Uncle Sam's very

own diet book, Dietary Guidelines for Americans 2005.

The guidelines, revised every five years, inevitably amount to a

compromise between nutrition advocates and the food and agriculture

lobbies. Yet this time they largely have pleased even staunch critics

of government food policy. " They look to me like the strongest

dietary guidelines yet produced, " said son, who heads

the Center for Science in the Public Interest, a nutrition advocacy

group in Washington DC, at a press conference after the release.

But in the aftermath, a philosophical divide has emerged. On the

one hand is the view, expressed by , that the government's

role is to put out information about what constitutes healthy eating,

but that it's up to individuals whether they follow the advice. The

other take is that the government must do more, not only to educate

people about food choice, but to ensure a food supply that accurately

reflects its own dietary advice. For those who take this view, the

guidelines don't go far enough — and they say that buried in the fine

print are concessions to the food industry that threaten to weaken

the impact of the advice.

The guidelines — a joint effort by the Department of Health and

Human Services (DHHS) and US Department of Agriculture (USDA) — were

first issued in 1980, and form a reference for US eating habits. They

underpin government nutritional policy and federal food programmes,

including school meals. And they will be summarized graphically in a

new 'food guidance system', which will be released within weeks to

replace the 'food pyramid' introduced in 1992.

Fat fighters

Previous guidelines focused on cutting consumption of the

saturated fats that cause chronic conditions such as heart disease.

But the top priority now is to roll back the obesity epidemic that is

causing a surge in conditions such as type-2 diabetes. About two-

thirds of US adults are deemed overweight or obese by the Centers for

Disease Control and Prevention in Atlanta, Georgia.

Consequently, the biggest change in the new guidelines is the

emphasis on restoring energy balance to people's diets. The message

is that there is no getting round the laws of thermodynamics. If your

calorie intake exceeds your energy output, you will gain weight. To

this end, the guidelines advise a close watch on calories and 30–60

minutes of exercise most days of the week; 90 minutes to shed

unwanted flab.

The US government's guidelines for a healthy diet were released in

January by Tommy , but some say influence from parties, such

as the sugar industry, will compromise the advice.

That's old hat to dieters, but the surprise this time was the

explicit statement that the healthiest way to reduce calories is to

avoid added sugars, certain fats and alcohol, all of which are high

in calories but low in essential nutrients. In the past, such a

message has been all but taboo. The previous guidelines say only that

added sugars may contribute to weight gain. And in January 2004, the

Bush administration lobbied against phrasing in the World Health

Organization's dietary advice that urged people to eat fewer sugary

and other high-calorie foods.

To hammer its point home, the scientific advisory committee behind

the guidelines turned to the concept of 'discretionary calories': the

number of junk-food calories you can eat daily without gaining

weight. A typical sedentary person who burns 2,200 calories per day

needs to eat about 1,910 calories of healthy food to meet their basic

nutritional needs. This leaves 290 calories for a treat, such as beer

and potato crisps with late-night TV.

The idea, say committee members, is to raise people's

consciousness about overeating without denying them their favourite

snacks. Even a relatively modest reduction of between 50 and 300

calories per day could prevent most new cases of obesity,

particularly among children. " If we could achieve this it would be

the major crowning achievement of the guidelines, " says Alice

Lichtenstein, a cardiovascular researcher at Tufts University School

of Medicine in Boston, Massachusetts, who sat on the scientific

committee for the 2000 guidelines.

Taste of the future

Also new this year is an emphasis on fibre- and nutrient-rich

whole grains instead of refined grains, and a recommendation to eat

nearly twice the quantity of fruit and vegetables suggested in the

2000 version, as a way to lower the risk of certain cancers, type-2

diabetes, stroke and obesity. And the guidelines now clearly

distinguish between different types of fat. Gone is the blanket low-

fat creed of the past 20 years. In its place is advice to avoid

saturated fats, which are found in red meat, for example, and trans-

fats, which are abundant in processed foods. At the same time,

moderate amounts of healthy fats, such as olive oil, are recommended.

The stronger wording in the new guidelines is partly the result of

changes to the drafting procedure that gave scientific advisers

greater autonomy. In 2003, the DHHS and USDA appointed 13 nutrition

scientists to the Dietary Guidelines Advisory Committee and asked

them to compile a report from the latest scientific literature.

Bureaucrats at the two agencies then reviewed this report, published

in the Federal Register in August 2004, and considered comments from

interested parties. They drafted the guidelines themselves, and

communications specialists transformed them into the slick, 84-page

brochures released in January.

Separating the two phases made the scientific basis of the

guidelines more transparent, says Janet King, chair of the committee

and a researcher at the Children's Hospital Oakland Research

Institute in Oakland, California. In the past, the committee members

had to write the actual guidelines, which forced them to consider

factors such as how easy they were for a lay reader to understand.

The previous committee spent ages, for example, debating whether to

advise people to 'limit' or 'moderate' their salt intake, King says.

The new set-up also made the committee less of a target for pressure

from industry and policy-makers. " It shielded us, " she says.

But the literature is far from definitive about the best diet.

There are few long-term or well-controlled clinical nutrition trials

available, so the committee relied heavily on epidemiological and

observational studies (see 'How is science converted to dietary

advice?' page 798 and Nature 428, 252–254; 2004).

These uncertainties left plenty of room for quibbling about the

wording of the guidelines, say critics of the process, who have been

quick to point out the fingerprints of the food industry in the small

print. One charge levelled at this and previous guidelines is that

they tell consumers only what foods they ought to eat — such as lean

cuts of meat and low-fat dairy products — without spelling out foods

to avoid, such as processed snacks, fast food or red meat dripping

with saturated fat. " They're saying the right thing but not quite

giving it the teeth it needs, " says Camargo, himself a member

of the scientific committee and an epidemiologist at the Harvard

School of Public Health in Boston.

Cream of the crop

A more specific industry influence, critics contend, is the

recommendation to consume more dairy products — the equivalent of

three cups of milk a day, up from between two and three cups last

time. They say that this increase provides most people with

unnecessary calories, that it is possible to achieve recommended

intakes of calcium and other nutrients through other means, and that

it fails to take into account studies linking diets high in dairy

products with an increased risk of prostate cancer. The increase

is " one of the strongest influences of the food industry " in the

report, says Walter Willett, a nutrition epidemiologist at the

Harvard School of Public Health.

Concerns have also been raised about the recommendation on trans-

fats. The scientific report said that these should not exceed 1% of

daily energy intake, but the guidelines say only that trans-fat

intake should be kept " as low as possible " . According to Camargo,

this was the most significant departure from the committee's

recommendations, allowing those putting together school meals, for

example, to make only a token effort to reduce the fat. Nutrition

researchers critical of the food industry charge that the language

was softened under industry pressure to avoid costly revamping of

production processes that rely on cheap vegetable oils.

For its part, the food industry says it is just trying to keep the

guidelines fair. Industry representatives, as well as other interest

groups, were invited to provide the committee with written and oral

comments during the literature-review phase and to make comments

after its report was published. The National Dairy Council, for

instance, presented evidence supporting its argument that dairy foods

help people meet their calcium and potassium requirements. And the

Grocery Manufacturers of America argued that added sugars help

increase the palatability of some nutritionally valuable foods.

Reaping benefits

But industry has other avenues of influence open to it. One is

through USDA, which, by the nature of its mission, is more attuned to

farmers' interests than to public-health needs. " It's the wrong

agency to do this, and a blatant conflict of interest, " says n

Nestle, a prominent critic of the food industry working at New York

University.

A second and more opaque route is through lobbying — an integral

part of the US political system — where industry and others try to

influence agency officials by, for example, providing them with

relevant documents and making personal contacts.

openly discussed industry's influence at the launch of

the guidelines. " The food industry has spent a great deal of time and

money appearing in and observing all of the negotiations and all of

the testimonies that went into compiling the guidelines, " he

said. " They come in and meet with me on a regular basis. "

Although industry may have won key concessions, anyone who follows

the guidelines strictly will probably end up in better health. The

reason some nutrition experts are still not happy is that they

anticipate little time or money will be put into spreading or

enforcing the advice.

" What is lacking is will on the part of the government and

Congress to convert the guidelines into new health and agriculture

policies and programmes, " says son. He asserts that doing so

would step on major interests such as restaurants, as well as the

corn, sugar, processed-food and salt industries. What is needed, he

says, are hard-hitting, mass-media campaigns to help shift consumer

demand to healthier products. Some also advocate legislation to

subsidize healthy foods, regulate advertising aimed at children, and

to require calorie information to be displayed on restaurant menus.

So far there is little sign that strong implementation is coming.

Instead, the US administration has emphasized that diet is a matter

of personal choice. " It's up to the individual to make the right

decisions, " said in January.

But Uauy, an expert on health and nutrition at the London

School of Hygiene and Tropical Medicine, argues that it is nearly

impossible to choose carbohydrates or fats " wisely " , as the

guidelines recommend, when many children's cereals contain as much as

40% sugar, for instance, and processed foods account for 80% of the

trans-fats that people eat. Nor is it easy for people to choose foods

with little salt — as the guidelines advise to lower blood pressure —

when 80% of their salt intake comes from processed foods.

Hard to swallow

Indeed, the US diet will have to change radically to meet the new

advice. At present, many Americans eat a diet that resembles the food

pyramid turned upside down, with too much salt and added sugars and

fats, and not enough grains, fruit and vegetables. Without

substantial changes in the practices of the food industry the

guidelines will have little impact, predicts Uauy.

" If people want French fries and a double cheeseburger we're gonna

give them that. "

Others say that the food industry is already going through a

period of evolution spurred in part by consumer demand. The public

discussion of obesity and related health problems has led to

increased awareness among consumers and greater scrutiny of the

industry by nutrition advocates and the media. Many fast-food chains

have updated their image with healthier fare such as salads and

yoghurts. Last year, Mc's phased out its 'supersize' meal

options. And PepsiCo has removed trans-fats from some of its snacks

and has introduced a greater range of bottled waters and fruit juices

as alternatives to sugary drinks.

At the same time, food companies are not about to abandon their

calorie-laden products as long as demand for them exists. " If people

want French fries and a double cheeseburger we're gonna give them

that, " says Bob Goldin, executive vice-president of Technomic, a food-

industry consulting and research firm based in Chicago.

But industry experts say that the shift towards healthier foods is

more than cosmetic. Health and whole foods are one of the biggest

growth areas in an otherwise saturated market, and companies are

scrambling for a share of it. They predict that consumer demand for

healthier food will grow, partly as a result of the dietary

guidelines. " It will be a driving factor in the industry going

forward, because that is what the consumer will ultimately want, "

Goldin says.

Certainly Americans are hungry for food advice, if $2 billion in

diet book sales last year is any indication. But whether it will take

more than a few books and a gentle nudge from their federal health

department to get them to eat better and slim down is still up in the

air.

http://www.healthierus.gov/dietaryguidelines

JONATHAN KNIGHT

Nature 433, 797 (24 February 2005)

Around the world in three square meals

In China, it's a pagoda; in Canada, a rainbow. But despite the

diversity of design to be found in pictorial food guides from around

the world, the core advice remains the same: eat your peas and

porridge, limit your bacon and eggs.

In Canada's rainbow, for instance, breads and cereals occupy the

outermost — and therefore longest — curve of the arc. This band is

coloured golden yellow to represent grain. Vegetables and fruit are

next in green, followed by dairy in blue and meat in the diminutive,

innermost red band.

Of course, in real rainbows, even Canadian ones, red comes before

yellow. Putting the colours in that order comes a bit closer to what

real Canadians eat. According to data from the United Nations Food

and Agriculture Organization, Canadians, like other North Americans,

get more than twice as many calories from meat and fish as from fruit

and vegetables.

That ratio is fairly common in parts of the world where meat is

readily available. The Chinese, avid consumers of pork, have a

similar proportion in their diets. This is despite the advice of the

Food Guide Pagoda, which has grain in its foundation level, and fruit

and veg just above it.

Nearly every official food guide emphasizes grains and cereals as

the foundation of a healthy diet, and that's one recommendation the

world as a whole has no trouble living up to. In the United States

and Europe, grains and cereals make up about a quarter of the average

diet. In Asia, where rice is a staple, they are anywhere from 50% to

60% of daily calories. Diets in most other regions fall somewhere in

the middle.

Although the basic recommendations are the same, each pyramid,

rainbow or circle tends to reflect the nation's unique food culture.

The Mexican food circle has an entire wedge devoted to beans. The

Chinese pagoda's food depictions include a bowl of rice and a head of

bok choy, and the German food circle features photographs of hearty

whole-grain breads.

But no food guide seems to take adequate account of the

irrepressible human sweet tooth. Sweets are listed along with fats as

only for occasional consumption in most guides. And several make no

mention of sweets at all, including those from China, Sweden, Germany

and Portugal (see J. Painter, J.-H. Rah and Y.-K. Lee J. Am. Diet.

Assoc. 102, 483–489; 2002). Even so, North Africans get 9% of their

calories from sugar, Europeans 11%, and Americans a cloying 18%.

Achim Schneider

Nature 433, 798 - 799 (24 February 2005); doi:10.1038/433798a

Food FAQs

Eating a healthy diet is hard work. There are hundreds of guides

out there — often providing conflicting instructions. Deciding what

advice to take means wrestling with a number of tough questions.

How is science converted to dietary advice?

To make the jump from scientific data to specific recommendations

for a healthy diet — that everyone should now eat nine servings of

fruit and vegetables a day, for instance — the scientists on the US

Dietary Guidelines Advisory Committee turned to computer modelling.

They mixed and matched foods from the traditional groups — fruits,

vegetables, grains, meat and beans, dairy foods, fats and sweets — to

come up with combinations that met nutritional requirements put

forward by the Institute of Medicine's Dietary Reference Intakes.

This gave them a series of food patterns for a range of daily calorie

intake levels from 1,000 to 3,200, in increments of 200. These model

diets were designed to boost nutrients that are often too low in US

diets, such as vitamin E, calcium, magnesium, potassium, fibre and

vitamin A.

In a twist, the nutritional value of each food group was

calculated to reflect what Americans actually eat, rather than as a

simple average of all the foods in the group. For example, broccoli

accounts for more than half of the greens Americans eat, and spinach

about a fifth, according to the 1999–2002 National Health and

Nutrition Examination Survey. So the value of the greens group as a

whole was calculated as having 0.53 of the nutritional values of

broccoli and 0.20 of those of spinach. The remainder was taken as the

combined average of other greens.

Committee members say that this approach allowed them to make

recommendations with practical value to Americans, who are not likely

to radically shift the proportions of foods they eat within the food

groups.

But the result did not entirely satisfy nutrition professionals.

Dena Bravata, a physician and obesity researcher at Stanford

University in California, says that although the guidelines are

valuable she would have preferred them to be " based more on the

scientific evidence rather than this hybrid approach " . The average US

diet is hardly ideal, she says, and knowing what food combinations

are optimal would allow patients and clinicians to create

individualized diets based on the best available evidence.

The approach has its disadvantages, the committee admits. Many

people in the United States don't get enough vitamin E, for example,

so one might have expected the guidelines to recommend eating more

nuts and oils, which are rich in this vitamin. But Americans eat very

few real nuts (peanuts, although popular, are actually legumes) and

use oils that are low in vitamin E, so nuts and oils ended up with

low vitamin E scores in the computation. This meant acrobatic

accounting to boost other food groups with average levels of vitamin

E.

Which countries or cultures have the best diets?

Several groups are in the running. Many people consider the

traditional Mediterranean diet to be one of the healthiest. But times

are changing. With the globalization of the food market, processed

foods are creeping into traditional diets at the same time that

physical activity is declining in many parts of the world. More and

more, the people with the best diets are those who make a concerted

effort.

In collaboration with the Harvard School of Public Health,

Oldways, a Boston-based non-profit organization that promotes healthy

eating, has assembled several traditional diets into food-guide

pyramids, following the shape of the official eating guide set out by

the US Department of Agriculture. These take traditional dietary

patterns into account, as well as data from clinical and

epidemiological research.

The Oldways Mediterranean pyramid is based on the diet of Greece,

Italy, Portugal and Spain around 1960, a time when people in those

countries lived longer than their northern European neighbours and

were less likely to develop heart disease. Their daily fare included

wholegrain bread, pasta, rice, fruit, beans, vegetables, cheese,

yoghurt and that quintessential Mediterranean ingredient, olive oil.

They also ate fish, poultry, eggs and sweets weekly. But red meat,

with its artery-clogging saturated fat, was consumed less often.

Today, these eating habits are gradually being abandoned, and at

the same time the Mediterranean advantage in life expectancy has

decreased1 and obesity is on the rise2. But the diet itself remains

popular among those who try to eat right. As a result, diet-conscious

people in places that lack strong nutritional traditions may be

candidates for the best eaters today. " Middle-aged, educated women in

California eat particularly healthy diets, " says Martijn Katan,

nutrition scientist at the Wageningen Centre for Food Sciences in the

Netherlands.

If effort is essential, certainly few countries have tried harder

to eat right than Finland. In the early 1970s, Finnish men had the

highest rate of heart disease in the world. Their diet consisted of

large amounts of whole milk, cheese and salt, with very little in the

way of fruit and vegetables. A national programme of education and

changes to the food supply over three decades has vastly improved the

national diet. Today, the mortality from coronary heart disease in

working-age men has been reduced to a quarter of what it was in the

1970s (ref. 3).

There must be a natural diet for humans — what did we evolve to

eat?

The good news is that evolution teaches us that humans can eat

just about any mix of the basic food groups. During evolution, we

have colonized almost every ecosystem on Earth, and adapted to what

was available; from Arctic populations eating almost exclusively

animal protein, to villagers in the peaks of the Andes living largely

on grains and cereals.

We evolved as " flexible eaters " , says Leonard, an

anthropologist at Northwestern University in ton, Illinois, and

an expert on diet in evolution. Taken from this evolutionary vantage

point, arguments in diet books over whether a low-fat, high-

carbohydrate diet is better than a high-protein, low-carb diet make

no sense, he says. Alice Lichtenstein, a cardiovascular researcher at

Tufts University School of Medicine in Boston who sat on the

scientific committee that produced the 2000 US dietary guidelines,

agrees. " A variety of diets are possible from an evolutionary point

of view, " she says.

The bad news is that evolution has also left us with a genetic

legacy: our brains and genes are hardwired to seek out as much energy

as possible for the least physical effort. This served humans well

during millennia when starvation was a constant threat to our

survival, but is not adapted to the modern world where high-calorie

foods are a phone order or short drive away.

Evidence for this can be found in the Arctic, for instance.

Indigenous people who maintain a traditional lifestyle eat a great

deal of meat, yet they have low blood lipid levels, which is a risk

factor in heart disease, and enjoy good cardiovascular health. The

explanation, Leonard proposes, is that their rate of metabolism is

raised as a result of vigorous physical activity and in response to

their frozen environment. But their relatives who have adopted a more

sedentary way of life, and a Western diet that has more processed

foods and less meat, have significantly increased blood lipid levels

and higher rates of obesity and cardiovascular disease4.

Such findings have implications for the hunt for 'fat genes'.

Although some genes may be linked to the risk of getting fat, obesity

is less the result of individual genetic propensities than of the

shift in environmental conditions, says Uauy, an expert on

public health and nutrition at the London School of Hygiene and

Tropical Medicine. " The past 50 years is too short to modify our

evolutionary trajectory. "

Do we have enough of the right kind of food for everyone on the

planet?

Certainly if one considers the world's chronically undernourished,

who now number some 850 million people5, the answer is no. But the

surprise is that many of those who are better off or who live in

countries with abundant food supplies still fail to get the nutrients

they need, and may even be overweight in spite of this.

The problem of chronic hunger occurs almost entirely in poor

countries. The condition is particularly lethal to children, of whom

more than 3.7 million died in 2002 from the health consequences of

being underweight. Another estimated 850,000 died because their diet —

although sufficiently rich in calories — did not contain enough

vital components such as iron, vitamin A and zinc5.

That lack of proper nutrients is also a phenomenon in wealthy

countries, where food insecurity, if not starvation, is surprisingly

common. In the United States, for example, 12.6 million households

(about 11%) fall short of basic food needs at some point during the

year. In about a quarter of those cases, people fail to get

government food aid or find private charities to make up the

difference, and so go hungry6.

Ironically, poverty and obesity often go hand in hand in developed

countries7. " Obesity is a disease of the poor in rich countries,

whereas in poor countries obesity is a disease of the rich, " says

Katan.

A key factor is that junk food tends to offer the most calories

for the least money. " This is the single most important factor

influencing food choice, " says n Nestle, professor of nutrition,

food studies and public health at New York University. In US

supermarkets, for instance, a 270-calorie doughnut costs about 75¢,

the same as 125-calorie apple.

The ready availability of processed and fast foods in many corners

of the globe is now making them the natural choice, particularly for

the poor and uneducated. Apart from being cheap, they have a natural

appeal, Nestle says. " Eating highly refined food rich in sugar and

fat is a kind of joy, which poor people do not frequently have, " she

says.

Although it is true that wholesome foods are also available

throughout the industrialized world, evidence suggests that even

slight inconvenience is enough to put people off buying them. A

representative study involving participants in the US food-stamp

programme shows that people tend to buy more fruit the closer they

live to a supermarket8.

References 1. Trichopoulos, D. & Lagiou, P. Public Health Nutr.

7, 949–951 (2004). | Article | PubMed |

2. Padez, C., Fernandes, T., Mourão, I., Moreira, P. & do, V. Am.

J. Hum. Biol. 16, 670–678 (2004). | Article | PubMed | ChemPort |

3. Puska, P. Acta Cardiol. 55, 213–220 (2000). | PubMed | ChemPort |

4. Leonard, W. R. et al. Annu. Rev. Anthropol. 34, (in the press).

5. The State of Food Insecurity in the World 2004 (UN Food and

Agriculture Organization, Rome, Italy, 2004); available at:

ftp://ftp.fao.org/docrep/fao/007/y5650e/y5650e00.pdf.

6. Nord, M., s, M. & Carlson, S. Food Assistance and Nutrition

Research Report no. 42: Household Food Security in the United States,

2003 (USDA Economic Research Service, Washington DC, 2004); available

at: http://www.ers.usda.gov/publications/fanrr42.

7. Drewnowski, A. & Specter, S. E. Am. J. Clin. Nutr. 79, 6–16

(2004). | PubMed | ChemPort |

8. Rose, D. & s, R. Public Health Nutr. 7, 1081–1088 (2004). |

Article | PubMed |

Cheers, Al Pater.

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