Startch, Fatty Acids and Prostate Cancer

[Guest guest]

This new study gives some credibility to Rodney's starch theory, I

don't remember seeing it listed before. It shows that poly fats are

inversely related to prostate cancer and mono fats and starch

adversely.

.........

Macronutrients, fatty acids, cholesterol and prostate cancer risk.

Bidoli E, Talamini R, Bosetti C, Negri E, Maruzzi D, Montella M,

Franceschi S, La Vecchia C.

Servizio di Epidemiologia e Biostatistica, Centro di Riferimento

Oncologico, Aviano (PN), Italy. epidemiology@...

BACKGROUND: The role of selected macronutrients, fatty acids and

cholesterol in the etiology of prostate cancer was analyzed using

data from a case-control study carried out in five Italian areas

between 1991 and 2002. PATIENTS AND METHODS: Cases were 1294 men

with incident, histologically confirmed prostate cancer, and

admitted to the major teaching and general hospitals of study areas.

Controls were 1451 men admitted for acute, non-neoplastic conditions

to the same hospital network. Information on dietary habits was

elicited using a validated food frequency questionnaire including 78

food groups and recipes. Odds ratios (OR) and 95% confidence

intervals (CI) were estimated for increasing levels of nutrient

intake. RESULTS: A direct association with prostate cancer was found

for starch intake (OR = 1.4 in the highest versus the lowest

quintile of intake; 95% CI: 1.1-1.8), whereas an inverse association

emerged for polyunsaturated fatty acids (OR = 0.8; 95% CI: 0.6-1.0).

Among polyunsaturated fatty acids, linolenic acid (OR = 0.7; 95% CI:

0.6-0.9) and linoleic acid (OR = 0.8; 95% CI: 0.6-1.0) were

inversely related to prostate cancer. When the six major

macronutrients were included in the same model, the adverse effect

of high intake of starch and monounsaturated fatty acids was

statistically significant together with the protective effect of

polyunsaturated fatty acids. Results were consistent in separate

strata of age, body mass index and family history of prostate

cancer. CONCLUSIONS: Starch and monounsaturated fatty acids were

directly associated with prostate cancer risk and polyunsaturated

fatty acids were inversely associated.

PMID: 15598953