Sunflower seeds? Linoleic acid biochem & effect on health

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Those look good too. Looking at things we could eat an oz of, peanut butter is not bad. I kinda think that using foods the linoleic comes in may be a better source of UNADULTERATED oils, since my first bottle of safflower oil was not what I wanted. There is ALWAYS someone playing in my food.

Here's a note on how linoleic works in the mitochondria another on effect on CVD, perhaps.

I read the first as interfering with the making of the lipoproteins.

PMID- 15060089-jw

TI - n-6 PUFAs down regulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms.

AB - The tricarboxylate (citrate) carrier (TCC), a protein of the mitochondrial inner membrane, is an obligatory component of the shuttle system by which mitochondrial acetyl-CoA is transported into the cytosol, where lipogenesis occurs. The aim of this study was to investigate the molecular basis for the regulation of TCC gene expression by a high-fat, n-6 PUFA-enriched diet. Rats received for up to 4 weeks a diet enriched with 15% safflower oil (SO), which is high in linoleic acid (70.4%). We found a gradual decrease of TCC activity and a parallel decline in the abundance of TCC mRNA, the maximum effect occurring after 4 weeks of treatment. At this time, the estimated half-life of TCC mRNA was the same in the hepatocytes from rats on both diets, whereas the transcriptional rate of TCC mRNA, tested by nuclear run-on assay, was reduced by approximately 38% in the rats on the SO-enriched diet. The RNase protection assay showed that the ratio of mature to precursor RNA, measured in the nuclei, decreased with the change to the n-6 PUFA diet. These results suggest that administration of n-6 PUFAs to rats leads to changes not only in the transcriptional rate of the TCC gene but also in the processing of the nuclear precursor for TCC RNA.

AD - Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Laboratorio di Biochimica, Universita di Lecce, I-73100 Lecce, Italy.

SO - J Lipid Res 2004 Jul;45(7):1333-40. Epub 2004 Apr 01.

PMID- 15050493-jw

TI - Polyunsaturated fatty acids acutely suppress antibodies to malondialdehyde-modified lipoproteins in patients with vascular disease.

AB - Antibodies to malondialdehyde (MDA)-modified low-density lipoprotein (LDL) are transiently reduced during the postprandial period in patients with atherosclerotic heart disease. Previous experiments using mixed meals high in fat have found reductions of approximately 20% within 2 hours. This study was designed to reveal if this phenomenon was due uniquely to saturated fats. Using a standardized immunoassay for the detection of circulating levels of autoantibodies (AAbs) against MDA-modified LDL, we examined the acute changes in AAb levels during 6 hours of postprandial lipemia in 10 men with known atherosclerotic heart disease. Each subject was given 4 meals 1 week apart. Three of the meals differed in content of saturated fat, monounsaturated fat, and polyunsaturated fat. A fat-free meal with equivalent carbohydrate and equivalent protein was also administered. The study was double blinded and the meals were administered in random order. Only the meal enriched with polyunsaturated fatty acids caused the reduction in antibodies to MDA-LDL. This decrease was statistically significant from baseline at 1 hour (p <0.05), 2 hours (p <0.004), and 3 hours (p <0.02), with the nadir occurring at 2 hours. Polyunsaturated fatty acids are the major stimulus for causing a reduction in the AAbs to MDA-LDL during postprandial lipemia. These results strongly suggest that fat in chylomicrons may be a major source of oxidized lipids in the blood of patients with arteriosclerosis.

SO - Am J Cardiol 2004 Apr 1;93(7):881-5.

----- Original Message -----

From: Francesca Skelton

Sent: Sunday, February 27, 2005 8:26 AM

Subject: Re: [ ] Re: How to Buy Oil/Sunflower seeds?

Well I thought of something like that. Not walnuts but sunflower seeds.They're very cheap (as I posted recently). Sold in bulk at Whole Foods forabout a dollar a pound and a pound goes a long, long way. According toTony, 1/4 cup a day will do it.I sprinkle them on our salads now and they add a nice texture, as well.What do you say, Tony?on 2/27/2005 5:57 AM, jwwright at jwwright@... wrote:> How about just using an oz of walnuts? The price is comparable.> Admittedly, some of the saffl is better but not available, and the grapeseed> is 60 miles, and it doesn't stay on the shelf for sure. How much of the saff> do you use?> I buy walnuts in 3# bags and freeze them.> > Regards.