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B12 and Osteoporosis

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New study supported by USDA's ARS. I couldn't find it yet. Assume it

will be soon published. Here's the pewaa release:

http://www.ars.usda.gov/News/docs.htm?docid=1261

Fight Osteoporosis: Bone Up on B12

By lie n Bliss

March 28, 2005

Women are about four times more likely than men to develop

osteoporosis, or weak, porous bones. But a new study links vitamin

B12 deficiency with low bone mineral density in men, and confirms

similar, previously reported findings in women.

Researchers funded by the Agricultural Research Service (ARS)

reported the findings in the Journal of Bone and Mineral Research.

The study was led by epidemiologist Tucker with the Jean

Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts

University in Boston, Mass. Tucker directs the HNRCA's Dietary

Assessment and Epidemiology Research Program.

While vitamin B12 deficiency has been linked with low levels of

markers of bone formation, the mechanism behind the relationship is

not known.

The scientists examined the relationship between vitamin B12 blood

levels and indicators of bone health measured in 2,576 men and

women, aged 30 to 87, participating in the Framingham Osteoporosis

Study. They found that those with vitamin B12 levels lower than 148

picomoles per liter (pM/L) were at greater risk of osteoporosis than

those with higher levels. Plasma B12 levels below 185 pM/L are

considered " very low, " according to some experts.

The study found that those with vitamin B12 concentrations below 148

pM/L had significantly lower average bone mineral density--at the

hip in men, and at the spine in women--than those with

concentrations above.

The range of symptoms of B-12 deficiency includes anemia, balance

disturbances and cognitive decline. Osteoporosis usually progresses

with no outward effect until a fracture occurs.

The recommended dietary allowance for vitamin B12 is 2.4 micrograms

per day for both men and women. Low stomach acid and aging can lower

the ability to absorb the vitamin. Those over age 50 are encouraged

to consume fortified foods or supplements containing B12.

This study suggests adequate vitamin B12 intake is important for

maintaining bone mineral density. Animal protein foods, such as

fish, liver, beef, pork, milk and cheese are good sources of vitamin

B12.

ARS is the U.S. Department of Agriculture's chief scientific

research agency

Mike

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